KEGG   ORTHOLOGY: K20573
Entry
K20573            Tight     KO                                     
Symbol
kanE, kanM2
Name
2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase [EC:2.4.1.301]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R10424  UDP-alpha-D-kanosamine:2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
R10425  UDP-alpha-D-kanosamine:neamine 1-alpha-D-kanosaminyltransferase
R10426  UDP-alpha-D-kanosamine:paromamine 1-alpha-D-kanosaminyltransferase
R10427  UDP-alpha-D-kanosamine:2'-deamino-2'-hydroxyparomamine 1-alpha-D-kanosaminyltransferase
R11271  UDP-alpha-D-glucose:2'-deamino-2'-hydroxyneamine alpha-D-glucosyltransferase
R11272  UDP-alpha-D-glucose:neamine alpha-D-glucosyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20573  kanE, kanM2; 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.301  2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
     K20573  kanE, kanM2; 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
Other DBs
COG: COG0438
Genes
AG: CAE46941(kanE)
Reference
PMID:15313224
  Authors
Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK
  Title
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.
  Journal
Arch Biochem Biophys 429:204-14 (2004)
DOI:10.1016/j.abb.2004.06.009
  Sequence
[ag:CAE46941]
Reference
PMID:19911031
  Authors
Kudo F, Sucipto H, Eguchi T
  Title
Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster.
  Journal
J Antibiot (Tokyo) 62:707-10 (2009)
DOI:10.1038/ja.2009.107
Reference
PMID:21983602
  Authors
Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ
  Title
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
  Journal
Nat Chem Biol 7:843-52 (2011)
DOI:10.1038/nchembio.671
LinkDB

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