KEGG   ORTHOLOGY: K20576
Entry
K20576            Tight     KO                                     
Symbol
aprD3
Name
NADP-dependent dehydrogenase [EC:1.1.1.-]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R11276  lividamine:NADP+ 4'-oxidoreductase
R11277  nebramine:NADP+ 4'-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20576  aprD3; NADP-dependent dehydrogenase
Other DBs
COG: COG1028
Genes
AG: CAF33052(aprD3)
Reference
PMID:27120352
  Authors
Lv M, Ji X, Zhao J, Li Y, Zhang C, Su L, Ding W, Deng Z, Yu Y, Zhang Q
  Title
Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis.
  Journal
J Am Chem Soc 138:6427-35 (2016)
DOI:10.1021/jacs.6b02221
  Sequence
[ag:CAF33052]
Reference
PMID:26879038
  Authors
Kim HJ, LeVieux J, Yeh YC, Liu HW
  Title
C3'-Deoxygenation of Paromamine Catalyzed by a Radical S-Adenosylmethionine Enzyme: Characterization of the Enzyme AprD4 and Its Reductase Partner AprD3.
  Journal
Angew Chem Int Ed Engl 55:3724-8 (2016)
DOI:10.1002/anie.201510635
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