KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
00902 Monoterpenoid biosynthesis
K20618 CYP76A26; nepetalactol monooxygenase
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450
K20618 CYP76A26; nepetalactol monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.161 nepetalactol monooxygenase
K20618 CYP76A26; nepetalactol monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, plant type
CYP76 family
K20618 CYP76A26; nepetalactol monooxygenase
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme thiolate) protein. It catalyses three successive reactions in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.
Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.161
R12253 7-Deoxyloganetic alcohol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Iridotrial + [Oxidized NADPH---hemoprotein reductase] + 2 H2O