Entry Name dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase;
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase
Reaction(IUBMB) 2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose [RN:
R09821 ]
Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose [CPD:
C19947 ]
Product S-adenosyl-L-homocysteine [CPD:
C00021 ];
dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose [CPD:
C19948 ]
Comment The enzyme is involved in the synthesis of dTDP-D-ravidosamine, the amino sugar moiety of the antibiotic ravidomycin V, which is produced by the bacterium Streptomyces ravidus.
History EC 2.1.1.236 created 2011
Pathway ec00523 Polyketide sugar unit biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology K20682 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
Reference Authors Kharel MK, Lian H, Rohr J
Title Characterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate.
Journal Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.236
LinkDB All DBs
