KEGG   ORTHOLOGY: K20682
Entry
K20682            Tight     KO                                     
Symbol
ravNMT
Name
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase [EC:2.1.1.236]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Reaction
R09821  S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K20682  ravNMT; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.236  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
     K20682  ravNMT; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
Other DBs
COG: COG0500
Genes
AG: CBH32796(RavNMT)
Reference
  Authors
Kharel MK, Nybo SE, Shepherd MD, Rohr J
  Title
Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters.
  Journal
Chembiochem 11:523-32 (2010)
DOI:10.1002/cbic.200900673
  Sequence
LinkDB

KEGG   ENZYME: 2.1.1.236
Entry
EC 2.1.1.236                Enzyme                                 
Name
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase;
RavNMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose [RN:R09821]
Reaction(KEGG)
R09821
Substrate
S-adenosyl-L-methionine [CPD:C00019];
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose [CPD:C19947]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose [CPD:C19948]
Comment
The enzyme is involved in the synthesis of dTDP-D-ravidosamine, the amino sugar moiety of the antibiotic ravidomycin V, which is produced by the bacterium Streptomyces ravidus.
History
EC 2.1.1.236 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20682  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
Reference
1  [PMID:21264378]
  Authors
Kharel MK, Lian H, Rohr J
  Title
Characterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate.
  Journal
Org Biomol Chem 9:1799-808 (2011)
DOI:10.1039/c0ob00854k
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.236
IUBMB Enzyme Nomenclature: 2.1.1.236
ExPASy - ENZYME nomenclature database: 2.1.1.236
BRENDA, the Enzyme Database: 2.1.1.236
LinkDB

KEGG   REACTION: R09821
Entry
R09821                      Reaction                               
Name
S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase
Definition
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-Adenosyl-L-methionine <=> dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-Adenosyl-L-homocysteine
Equation
C19947 + 2 C00019 <=> C19948 + 2 C00021
Reaction class
RC00003  C00019_C00021
RC01515  C19947_C19948
Enzyme
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.236
     R09821  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-Adenosyl-L-methionine <=> dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-Adenosyl-L-homocysteine
Orthology
K20682  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase [EC:2.1.1.236]
Other DBs
RHEA: 31618
LinkDB

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