KEGG ORTHOLOGY: K20877

ORTHOLOGY: K20877

Entry

K20877                      KO

Symbol

NEK8

Name

serine/threonine-protein kinase Nek8 [EC:2.7.11.1]

Disease

H00537

Nephronophthisis

H00542

Polycystic kidney disease

H00543

Renal-hepatic-pancreatic dysplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K20877  NEK8; serine/threonine-protein kinase Nek8
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K20877  NEK8; serine/threonine-protein kinase Nek8
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K20877  NEK8; serine/threonine-protein kinase Nek8
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  NEK family
   K20877  NEK8; serine/threonine-protein kinase Nek8
Cilium and associated proteins [BR:ko03037]
Primary cilia and associated proteins
  Other primary cilia associated proteins
   K20877  NEK8; serine/threonine-protein kinase Nek8

Genes

HSA:	284086(NEK8)

PTR:	455033(NEK8)

PPS:	100987638(NEK8)

GGO:	101151658(NEK8)

PON:	100462534(NEK8)

PPYG:

129017862(NEK8)

NLE:	100602910(NEK8)

HMH:	116474597(NEK8)

SSYN:

129469780(NEK8)

MCC:	716323(NEK8)

MCF:	102144108(NEK8)

MTHB:

126938750

MNI:	105476385(NEK8)

CSAB:

103242632(NEK8)

CATY:

105591531(NEK8)

PANU:

101026163(NEK8)

TGE:	112609224(NEK8)

MLEU:

105552025(NEK8)

RRO:	104669389(NEK8)

RBB:	108539935(NEK8)

TFN:	117066439(NEK8)

PTEH:

111520828(NEK8)

CANG:

105510841(NEK8)

CJC:	100404400(NEK8)

SBQ:	101050121(NEK8)

CIMI:

108313578(NEK8)

ANAN:

105715114(NEK8)

CSYR:

103269115(NEK8)

MMUR:

105857885(NEK8)

LCAT:

123620263(NEK8)

PCOQ:

105813517(NEK8)

OGA:	100949050(NEK8)

MMU:	140859(Nek8)

MCAL:

110305045(Nek8)

MPAH:

110332118(Nek8)

RNO:	287473(Nek8)

MCOC:

116078915(Nek8)

ANU:	117711127(Nek8)

ASYL:

127693562(Nek8)

MUN:	110544636(Nek8)

CGE:	100762577(Nek8)

MAUA:

101832038(Nek8)

PROB:

127218870(Nek8)

PLEU:

114691490(Nek8)

MORG:

121456766(Nek8)

MFOT:

126492287

AAMP:

119812421(Nek8)

NGI:	103730463(Nek8)

HGL:	101715978(Nek8)

CPOC:

100723452(Nek8)

CCAN:

109685886(Nek8)

DORD:

105985662(Nek8)

DSP:	122117974(Nek8)

PLOP:

125365842(Nek8)

NCAR:

124979913

MMMA:

107155249(Nek8)

ITI:	101965642(Nek8)

OCU:

100345106

OPI:	101522981(NEK8)

TUP:	102496393(NEK8)

GVR:	103598600(NEK8)

CFA:	491171(NEK8)

CLUD:

112677654(NEK8)

VVP:	112933138(NEK8)

VLG:	121473016(NEK8)

NPO:	129497268(NEK8)

AML:	100464712(NEK8)

UMR:	103667408(NEK8)

UAH:	113269046(NEK8)

UAR:	123776939(NEK8)

ELK:

111151786

LLV:

125087051

MPUF:

101680651(NEK8)

MNP:	132004223(NEK8)

MLK:	131816557(NEK8)

NVS:	122906400(NEK8)

ORO:	101365704(NEK8)

EJU:	114214011(NEK8)

ZCA:	113939325(NEK8)

MLX:	118025275(NEK8)

NSU:	110593027(NEK8)

LWW:	102748332(NEK8)

FCA:	101084837(NEK8)

PYU:	121017220(NEK8)

PBG:	122485150(NEK8)

PVIV:

125151849(NEK8)

LRUF:

124513241

LGF:	123603252(NEK8)

AJU:

106983232

PTG:	102950846(NEK8)

PPAD:

109251837(NEK8)

PUC:

125926830

PLEZ:

122206460(NEK8)

HHV:	120246532(NEK8)

BTA:	532332(NEK8)

BOM:	102269595(NEK8)

BIU:	109574431(NEK8)

BBUB:

102397643(NEK8)

BBIS:

105004155

CHX:	102169047(NEK8)

OAS:	101107205(NEK8)

BTAX:

128065147(NEK8)

CSUM:

138084005(NEK8)

ODA:	120866283(NEK8)

CCAD:

122448329(NEK8)

MREE:

136149852(NEK8)

OVR:	110131806(NEK8)

MBEZ:

129540743(NEK8)

SSC:	100514006(NEK8)

CFR:	102503842(NEK8)

CBAI:

105071561(NEK8)

CDK:	105088172(NEK8)

VPC:	102527328(NEK8)

BACU:

103017847(NEK8)

BMUS:

118886706(NEK8)

LVE:	103082027(NEK8)

OOR:	101274010(NEK8)

LALB:

132511814(NEK8)

DLE:	111185839(NEK8)

PCAD:

102980700(NEK8)

PSIU:

116746142(NEK8)

NASI:

112394474(NEK8)

ECB:	100059451(NEK8)

EPZ:	103555955(NEK8)

EAI:	106844573(NEK8)

MYB:	102240356(NEK8)

MYD:	102767886(NEK8)

MMYO:

118671840(NEK8)

MLF:	102432334(NEK8)

MDT:	132218298(NEK8)

MYUM:

138993724(NEK8)

PKL:	118702602(NEK8)

EFUS:

103291724(NEK8)

MNA:	107528736(NEK8)

DRO:	112308649(NEK8)

SHON:

119003462(NEK8)

AJM:	119062020(NEK8)

PDIC:

114503218(NEK8)

PHAS:

123817688(NEK8)

MMF:	118634842(NEK8)

PPAM:

129070145(NEK8)

HAI:	109385155(NEK8)

RFQ:	117013037(NEK8)

PALE:

102879711(NEK8)

PGIG:

120620966(NEK8)

PVP:	105291907(NEK8)

RAY:	107507777(NEK8)

MJV:	108384048 118970539

TOD:	119231845(NEK8)

SARA:

101545655(NEK8)

SFUM:

130035825(NEK8)

SETR:

126007915(NEK8)

LAV:	100659172(NEK8)

TMU:

101356751

ETF:	101653873(NEK8)

DNM:	101428228(NEK8)

MDO:	100024946(NEK8)

GAS:	123244391(NEK8)

SHR:	100932453(NEK8)

AFZ:

127558913

PCW:	110192192(NEK8)

TVP:	118858608(NEK8)

PBRV:

138162528(NEK8)

OAA:	100081786(NEK8)

TACU:

119939551(NEK8)

GGA:	417576(NEK8)

PCOC:

116228052(NEK8)

MGP:	100542104(NEK8)

CJO:	107322688(NEK8)

TPAI:

128083732(NEK8)

LMUT:

125702970(NEK8)

NMEL:

110407750(NEK8)

APLA:

101794468(NEK8)

ACYG:

106049422(NEK8)

CATA:

118255198(NEK8)

AFUL:

116497272(NEK8)

TGU:	100229959(NEK8)

LSR:	110481997(NEK8)

SCAN:

103820127(NEK8)

PMOA:

120507631(NEK8)

OTC:	121345796(NEK8)

PRUF:

121361705(NEK8)

ATRC:

139599962(NEK8)

GFR:	102043078(NEK8)

OMA:	130260791(NEK8)

PHI:	102112876(NEK8)

PMAJ:

107212991(NEK8)

CCAE:

111937766(NEK8)

CCW:	104691057(NEK8)

CBRC:

103616253(NEK8)

ACOE:

138120588(NEK8)

ETL:	114061248(NEK8)

ZAB:	102065542(NEK8)

ZLE:	135455904(NEK8)

ACHL:

103798844(NEK8)

SVG:	106853401(NEK8)

MMEA:

130576981(NEK8)

HRT:	120761291(NEK8)

SATI:

136370118(NEK8)

CCIC:

134052562(NEK8)

FPG:	101915757(NEK8)

FCH:	102050691(NEK8)

CCRI:

104168447(NEK8)

NNT:	104402595(NEK8)

SHAB:

115601936(NEK8)

ACUN:

113487026(NEK8)

TALA:

104357031(NEK8)

ACHC:

115347564(NEK8)

HALD:

104313166(NEK8)

HLE:	104835587(NEK8)

AGEN:

126039143

HHAR:

128149316(NEK8)

GCL:

127024455

CSTI:

104563171(NEK8)

LDI:	104351614(NEK8)

MNB:	103769165(NEK8)

DPUB:

104302771(NEK8)

PPUS:

135187520(NEK8)

AVIT:

104278344(NEK8)

EGZ:	104131855(NEK8)

NNI:	104012755(NEK8)

PCRI:

104034304(NEK8)

PCAO:

104049068(NEK8)

PADL:

103918822(NEK8)

AFOR:

103897975(NEK8)

FGA:	104075145(NEK8)

GSTE:

104254153(NEK8)

CLV:	102091014(NEK8)

MUI:	104537765(NEK8)

PGUU:

104463256(NEK8)

PLET:

104622386(NEK8)

EHS:	104510827(NEK8)

CMAC:

104480455(NEK8)

CUCA:

104058653(NEK8)

TEO:	104382053(NEK8)

BREG:

104640510(NEK8)

OHA:	104332789(NEK8)

ACAR:

104528686(NEK8)

CPEA:

104397358(NEK8)

CVF:	104288429(NEK8)

RTD:	128912932(NEK8)

CRID:

134518550(NEK8)

AAM:	106487799(NEK8)

AROW:

112960687(NEK8)

NPD:	112954550(NEK8)

TGT:	104565482(NEK8)

DNE:	112986351(NEK8)

SCAM:

104153718(NEK8)

ASN:	102386453(NEK8)

AMJ:	102574311(NEK8)

CPOO:

109317248(NEK8)

GGN:	109293373(NEK8)

PSS:

102456278

CMY:	102940595(NEK8)

CCAY:

125624061(NEK8)

DCC:	119844579(NEK8)

CPIC:

101937924(NEK8)

TST:	117867569(NEK8)

CABI:

116829733(NEK8)

MRV:	120387147(NEK8)

ASAO:

132763290(NEK8)

PVT:	110084283(NEK8)

SUND:

121916804(NEK8)

PBI:	103062890(NEK8)

PMUR:

107299587(NEK8)

CTIG:

120318173(NEK8)

PGUT:

117669808(NEK8)

APRI:

131188763(NEK8)

VKO:	123023639(NEK8)

PMUA:

114585135(NEK8)

PRAF:

128402819(NEK8)

ZVI:	118096943(NEK8)

HCG:	128335988(NEK8)

GJA:	107119424(NEK8)

STOW:

125446020(NEK8)

EMC:	129345029(NEK8)

XLA:	779142(nek8.S)

XTR:	448753(nek8)

NPR:	108785851(NEK8)

RTEM:

120927695(NEK8)

BBUF:

120994671(NEK8)

BGAR:

122924328 122932616(NEK8)

PWL:	138285808(NEK8)

MUO:	115456757(NEK8)

GSH:	117349242(NEK8)

DRE:	171094(nek8)

SRX:

107758702

SANH:

107661116 107672375

SGH:	107582647 107592757

CCAR:

109067141(nek8)

CAUA:

113115236(nek8)

CGIB:

127972138

PTET:

122359581(nek8)

LROH:

127177784(nek8)

OMC:	131520913(nek8)

PPRM:

120479009(nek8)

RKG:	130077829(nek8)

MAMB:

125248395(nek8) 125262677

CIDE:

127494943

CERY:

137004733(nek8)

MASI:

127422490

TROS:

130564885(nek8)

TDW:	130428756(nek8)

MANU:

129437808(nek8)

PDAB:

135771291(nek8)

IPU:

108277969

IFU:	128621252(nek8)

PHYP:

113532548(nek8)

SMEO:

124394840(nek8)

TFD:	113636779(nek8)

TVC:	132857916(nek8)

CGAR:

128532710(nek8)

NGRA:

132901369(nek8)

TRN:	134334374(nek8)

AMEX:

103024333(nek8)

CMAO:

118799413(nek8)

EEE:	113587657(nek8)

CHAR:

105911028(nek8)

SPIL:

134099534(nek8)

TRU:	101062697(nek8)

TFS:	130534934(nek8)

TNG:	GSTEN00030114G001

LCO:	104933841(nek8)

NCC:	104947729(nek8)

TBEN:

117468748(nek8)

CGOB:

115017702(nek8)

PGEO:

117456937(nek8)

GACU:

117540383(nek8)

EMAC:

134879769(nek8)

ELY:	117259502(nek8)

EFO:	125888370(nek8)

PLEP:

121943539(nek8)

SLUC:

116048455(nek8)

ECRA:

117942261(nek8)

ESP:	116674156(nek8)

PFLV:

114553365(nek8)

GAT:	120821508(nek8)

PPUG:

119218759(nek8)

AFB:	129095719(nek8)

CLUM:

117742013(nek8)

PSWI:

130211186(nek8)

CANA:

137790593(nek8)

CVE:	137875934(nek8)

MSAM:

119882581(nek8)

SCHU:

122878427(nek8)

CUD:	121515773(nek8)

SPUL:

138597185(nek8)

LMIX:

132980654(nek8)

ALAT:

119011526(nek8)

ASTR:

137596740(nek8)

MZE:	101478791(nek8)

ONL:	100693139(nek8)

OAU:	116313870(nek8)

OLA:	101161178(nek8)

OML:	112149229(nek8)

CSAI:

133442413(nek8)

XMA:	102217710(nek8)

XCO:	114133571(nek8)

XHE:	116737493(nek8)

PRET:

103474189(nek8)

PFOR:

103148534(nek8)

PLAI:

106963642(nek8)

PMEI:

106932494(nek8)

GAF:	122832965(nek8)

PPRL:

129369756(nek8)

CVG:	107090483(nek8)

CTUL:

119795437(nek8)

GMU:	124883832(nek8)

NFU:	107379985(nek8)

KMR:	108247277(nek8)

ALIM:

106528833(nek8)

NWH:	119410941(nek8)

AOCE:

111580069(nek8)

EJA:	138205356(nek8)

BFRE:

138628965(nek8)

MCEP:

125013545(nek8)

CSEM:

103378250(nek8)

POV:	109629963(nek8)

SSEN:

122773933(nek8)

SSOE:

131463136(nek8)

HHIP:

117772406(nek8)

HSP:	118106658(nek8)

PPLT:

128440044(nek8)

SMAU:

118299218(nek8)

LCF:

108876048

SDU:	111232320(nek8)

SLAL:

111650678(nek8)

XGL:	120792075(nek8)

HCQ:	109514827(nek8)

SSCV:

125972659(nek8)

SBIA:

133504964(nek8)

PEE:	133404849(nek8)

PTAO:

133482008(nek8)

BPEC:

110163667(nek8)

ENY:	140380408(nek8)

MALB:

109972099(nek8)

BSPL:

114867696(nek8)

SJO:	128360603(nek8)

SSCO:

133980392(nek8)

GMH:	115528755(nek8)

SASA:

106581190(nek8)

STRU:

115163412(nek8)

OTW:	112265511(nek8)

OMY:	110507755(nek8)

OGO:

123992750

ONE:	115136759(nek8)

OKI:	109905701(nek8)

OKE:	118397445(nek8)

OMM:

135552921

OCLA:

139386107

SALP:

111949561(nek8)

SNH:

120018542

CCLU:

121560183 121567952

ELS:	105024941(nek8)

OEP:	134029543(nek8)

SFM:	108932055(nek8)

PKI:	111847151(nek8)

AANG:

118209588(nek8)

AROT:

135235976(nek8)

CCOG:

133108232(nek8)

LOC:	102689700(nek8)

PSPA:

121308775(nek8)

ARUT:

117429502 117430602

PSEX:

120522016(nek8)

LCM:	102346552(NEK8)

CMK:	103183363(nek8)

RTP:	109921887(nek8)

CPLA:

122563985(nek8)

HOC:	132830435(nek8)

LERI:

129710887(nek8)

PMRN:

116957761 116957763

LRJ:	133348994(NEK8)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG10951(niki)

DER:

6554486

DSE:	6607808 6621779

DSI:	Dsimw501_GD18266(Dsim_GD18266)

DYA:	Dyak_GE10771

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10715

DAZ:

108608630

DNV:

108659220

DHE:

111594825

DVI:	6631021(niki)

CCAT:

101457292

BOD:

106622408

BDR:

105229534

RZE:	108376394 108376684

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135963965(niki)

GFS:

ECOE:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ018315

CPII:

BCOO:

LLL:

PPAP:

TCA:

TMOL:

138134681(niki)

ATD:

NVL:

PPYR:

OTU:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

CLEC:

HHAL:

HVI:	124360492 124372213

HAMR:

PVM:

PJA:

PCHN:

HAME:

PCLA:

CQD:

MNZ:	135206513 135206703

MRJ:

PORN:

EAF:

TCF:

DSV:

RSAN:

RMP:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_ZC581.1(nekl-2)

CBR:	CBG_12695(Cbr-nekl-2)

CRQ:	GCK72_001816

NAI:	NECAME_02185

HRO:	HELRODRAFT_129966

LGI:	LOTGIDRAFT_120493

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:	116601992 5518351

EPA:

ATEN:

ADF:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_28793

AQU:

100639236

SRE:	PTSG_02940

» show all

Reference

PMID:15019993

Authors

Bowers AJ, Boylan JF

Title

Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.

Journal

Gene 328:135-42 (2004)
DOI:10.1016/j.gene.2003.12.002

Sequence

[hsa:284086]

LinkDB

DBGET integrated database retrieval system