KEGG   ORTHOLOGY: K20985
Entry
K20985            Tight     KO                                     
Symbol
LOVG
Name
dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase [EC:3.1.2.31]
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00893  Lovastatin biosynthesis, malonyl-CoA => lovastatin acid
Reaction
R11187  dihydromonacolin L-[acyl-carrier protein] hydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various other secondary metabolites
    K20985  LOVG; dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.31  dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase
     K20985  LOVG; dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase
Genes
AG: EAU29411(LOVG)
Reference
  Authors
Xu W, Chooi YH, Choi JW, Li S, Vederas JC, Da Silva NA, Tang Y
  Title
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.
  Journal
Angew Chem Int Ed Engl 52:6472-5 (2013)
DOI:10.1002/anie.201302406
  Sequence
LinkDB

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