KEGG   ORTHOLOGY: K21050
Entry
K21050                      KO                                     
Symbol
US2
Name
HCMV unique short US2 glycoprotein
Pathway
map05163  Human cytomegalovirus infection
Network
nt06129  MHC presentation (viruses)
nt06167  Human cytomegalovirus (HCMV)
  Element
N00418  HCMV US2/11 to antigen processing and presentation by MHC class I molecules
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K21050  US2; HCMV unique short US2 glycoprotein
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K21050  US2; HCMV unique short US2 glycoprotein
Viral proteins [BR:ko03200]
 dsDNA viruses
  Human cytomegalovirus (Human herpesvirus 5)
   K21050  US2; HCMV unique short US2 glycoprotein
Other DBs
GO: 0042288
Genes
VG: 3077542(US2) 935458(US2)
Reference
PMID:8945469
  Authors
Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL
  Title
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.
  Journal
Nature 384:432-8 (1996)
DOI:10.1038/384432a0
  Sequence
[vg:3077542]
Reference
  Authors
Tomazin R, Boname J, Hegde NR, Lewinsohn DM, Altschuler Y, Jones TR, Cresswell P, Nelson JA, Riddell SR, Johnson DC
  Title
Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells.
  Journal
Nat Med 5:1039-43 (1999)
DOI:10.1038/12478
  Sequence
[vg:3077542]
Reference
  Authors
Han J, Rho SB, Lee JY, Bae J, Park SH, Lee SJ, Lee SY, Ahn C, Kim JY, Chun T
  Title
Human cytomegalovirus (HCMV) US2 protein interacts with human CD1d (hCD1d) and down-regulates invariant NKT (iNKT) cell activity.
  Journal
Mol Cells 36:455-64 (2013)
DOI:10.1007/s10059-013-0221-8
  Sequence
[vg:3077542]
LinkDB

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