KEGG   ORTHOLOGY: K21058
Entry
K21058                      KO                                     
Symbol
bciC
Name
chlorophyllide a hydrolase [EC:3.1.1.100]
Pathway
map00860  Porphyrin metabolism
map01110  Biosynthesis of secondary metabolites
Reaction
R09061  chlorophyllide-a hydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K21058  bciC; chlorophyllide a hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.100  chlorophyllide a hydrolase
     K21058  bciC; chlorophyllide a hydrolase
Genes
CAU: Caur_0916
CHL: Chy400_1001
CAG: Cagg_2236
CALL: OZ401_003683
CTM: Cabther_B0081
CVL: J8C06_12195
CHLO: J8C02_13080
CTE: CT1077
CPC: Cpar_1043
CLZ: BIU88_05675
CCH: Cag_1069
CPH: Cpha266_1276
CPB: Cphamn1_1371
CLI: Clim_1212
PVI: Cvib_0856
PLT: Plut_1085
PPH: Ppha_1315
PAA: Paes_1150
PROC: Ptc2401_01155
PRS: B9H02_05810
PROS: CHL67_05920
PROW: OO006_06325
PROI: OO005_05855
CTS: Ctha_2200
 » show all
Reference
PMID:21550979
  Authors
Liu Z, Bryant DA
  Title
Identification of a gene essential for the first committed step in the biosynthesis of bacteriochlorophyll c.
  Journal
J Biol Chem 286:22393-402 (2011)
DOI:10.1074/jbc.M111.249433
  Sequence
[cte:CT1077] [ctm:Cabther_B0081]
LinkDB

KEGG   ENZYME: 3.1.1.100
Entry
EC 3.1.1.100                Enzyme                                 
Name
chlorophyllide a hydrolase;
bciC (gene name)
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
chlorophyllide-a hydrolase
Reaction(IUBMB)
chlorophyllide a + H2O = 8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide d + methanol + CO2 [RN:R09061]
Reaction(KEGG)
R09061
Substrate
chlorophyllide a [CPD:C02139];
H2O [CPD:C00001]
Product
8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide d;
methanol [CPD:C00132];
CO2 [CPD:C00011]
Comment
This enzyme, found in green sulfur bacteria (Chlorobiaceae) and green filamentous bacteria (Chloroflexaceae), catalyses the first committed step in the biosynthesis of bacteriochlorophylls c, d, and e, the removal of the C-132-methylcarboxyl group from chlorophyllide a. The reaction is very similar to the conversion of pheophorbide a to pyropheophorbide a during chlorophyll a degradation, which is catalysed by EC 3.1.1.82, pheophorbidase.
History
EC 3.1.1.100 created 2016
Pathway
ec00860  Porphyrin metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K21058  chlorophyllide a hydrolase
Genes
CAU: Caur_0916
CHL: Chy400_1001
CAG: Cagg_2236
CALL: OZ401_003683
CTM: Cabther_B0081
CVL: J8C06_12195
CHLO: J8C02_13080
CTE: CT1077
CPC: Cpar_1043
CLZ: BIU88_05675
CCH: Cag_1069
CPH: Cpha266_1276
CPB: Cphamn1_1371
CLI: Clim_1212
PVI: Cvib_0856
PLT: Plut_1085
PPH: Ppha_1315
PAA: Paes_1150
PROC: Ptc2401_01155
PRS: B9H02_05810
PROS: CHL67_05920
PROW: OO006_06325
PROI: OO005_05855
CTS: Ctha_2200
 » show all
Reference
1  [PMID:21550979]
  Authors
Liu Z, Bryant DA
  Title
Identification of a gene essential for the first committed step in the biosynthesis of bacteriochlorophyll c.
  Journal
J Biol Chem 286:22393-402 (2011)
DOI:10.1074/jbc.M111.249433
  Sequence
[cte:CT1077] [ctm:Cabther_B0081]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.100
IUBMB Enzyme Nomenclature: 3.1.1.100
ExPASy - ENZYME nomenclature database: 3.1.1.100
BRENDA, the Enzyme Database: 3.1.1.100
LinkDB

KEGG   REACTION: R09061
Entry
R09061                      Reaction                               
Name
chlorophyllide-a hydrolase
Definition
Chlorophyllide + H2O <=> 8-Ethyl-12-methyl-3-vinylbacteriochlorophyllide d + Methanol + CO2
Equation
C02139 + C00001 <=> C18157 + C00132 + C00011
Reaction class
RC02390  C02139_C18157
Enzyme
3.1.1.100
Pathway
rn00860  Porphyrin metabolism
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.100
     R09061  Chlorophyllide + H2O <=> 8-Ethyl-12-methyl-3-vinylbacteriochlorophyllide d + Methanol + CO2
Orthology
K21058  chlorophyllide a hydrolase [EC:3.1.1.100]
Other DBs
RHEA: 49187
LinkDB

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