KEGG   ORTHOLOGY: K21075
Entry
K21075                      KO                                     
Symbol
UL36, UL48
Name
Herpesviridae large tegument protein deneddylase [EC:3.4.19.12 3.4.22.-]
Pathway
map03266  Virion - Herpesvirus
map05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06519  RLR signaling
  Element
N00566  HSV UL36USP to RIG-I-like receptor signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03266 Virion - Herpesvirus
    K21075  UL36, UL48; Herpesviridae large tegument protein deneddylase
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K21075  UL36, UL48; Herpesviridae large tegument protein deneddylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K21075  UL36, UL48; Herpesviridae large tegument protein deneddylase
  09185 Viral protein families
   03200 Viral proteins
    K21075  UL36, UL48; Herpesviridae large tegument protein deneddylase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     K21075  UL36, UL48; Herpesviridae large tegument protein deneddylase
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C76
   K21075  UL36, UL48; Herpesviridae large tegument protein deneddylase
Viral proteins [BR:ko03200]
 dsDNA viruses
  Other herpesvirus
   K21075  UL36, UL48; Herpesviridae large tegument protein deneddylase
Other DBs
GO: 0036459 0019784
Genes
VG: 10192255(RHVP.64) 11294070(KM472_gp077) 11464121(UL48) 11464278(UL48) 12413928(ORF24) 14039108(E48) 1450445(AtHV3gp61) 14536648(GP48) 1461044(ORF64) 1487322(UL36) 1487431(UL36) 1487490(ORF24) 1487588(ORF24) 1487704(ORF22) 1487907(U31) 1497033(U31) 1497174(GAMMAHV.ORF64) 15486231(U31) 16747420(U31) 1682468(SaHV2gp65) 1684939(BoHV4gp63) 18533928(UL36) 19620198(BoHV6ORF64) 19621680(UL36) 19735539(ALHV2gp61) 19738338(HQ28_gp050) 20098476(U31) 20194334(ORF24) 23104201(ORF64) 24284873(AA805_gp68) 25026464(UL48) 26100458(AQ624_gp73) 26196578(U31) 26684037(AWE45_gp62) 26828108(UL36) 26836983(ORF64) 26887564(UL36) 2703357(UL36) 27815336(UL36) 27912042(U31) 2952494(UL36) 2952834(grh78) 3077504(UL48) 30855064(BWV06_gp052) 30902387(UL36) 30999383(ORF42) 3190326(UL36) 32014198(B7477_gp050) 32707796(UL36) 3289489(U31) 33194276(ORF64) 3416495(JM124) 36931261(BHV5-20) 3850219(UL36) 40524698(UL36) 41701003(EXJ68_gp66) 41701501(ORF71) 4811510(MDV049) 4961441(ORF64) 65099417(KM477_gp68) 65099512(KM481_gp61) 65099603(ORF64) 65099975(UL36) 65101017(ORF64) 65102717(ORF64) 65102791(ORF64) 7070115(ORF24) 72301787(UL36) 80531883(UL36) 80531935(UL36) 80532006(UL36) 80532083(ORF24) 80532486(UL36) 80532551(UL36) 80532793(UL36) 80535074(UL36) 80535168(UL36) 80537006(UL36) 80537054(UL36) 80540132(QKT44_gp24) 80540223(UL36) 80540488(UL36) 80541547(U31) 8223350(UL36) 8658551(UL36) 911802(AlHV1gp61) 911901(UL36) 918502(HVT044) 920530(ORF22) 921136(THVgp073) 934967(MmrVgp74) 935563(UL48) 940380(R48) 955925(CalHV3gp62) 9829320(UL36)
Reference
PMID:16109378
  Authors
Kattenhorn LM, Korbel GA, Kessler BM, Spooner E, Ploegh HL
  Title
A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae.
  Journal
Mol Cell 19:547-57 (2005)
DOI:10.1016/j.molcel.2005.07.003
  Sequence
[vg:2703357]
Reference
PMID:18495763
  Authors
Shanda SK, Wilson DW
  Title
UL36p is required for efficient transport of membrane-associated herpes simplex virus type 1 along microtubules.
  Journal
J Virol 82:7388-94 (2008)
DOI:10.1128/JVI.00225-08
  Sequence
[vg:2703357]
Reference
PMID:18971278
  Authors
Roberts AP, Abaitua F, O'Hare P, McNab D, Rixon FJ, Pasdeloup D
  Title
Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1.
  Journal
J Virol 83:105-16 (2009)
DOI:10.1128/JVI.01032-08
  Sequence
[vg:2703357]
Reference
PMID:26764006
  Authors
Kim YE, Oh SE, Kwon KM, Lee CH, Ahn JH
  Title
Involvement of the N-Terminal Deubiquitinating Protease Domain of Human Cytomegalovirus UL48 Tegument Protein in Autoubiquitination, Virion Stability, and Virus Entry.
  Journal
J Virol 90:3229-42 (2016)
DOI:10.1128/JVI.02766-15
  Sequence
[vg:3077504]
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