KEGG ORTHOLOGY: K21161

ORTHOLOGY: K21161

Entry

K21161                      KO

Symbol

sgcE3, ncsE3, kedE3

Name

enediyne biosynthesis protein E3

Pathway

map01059

Biosynthesis of enediyne antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00824

9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21161  sgcE3, ncsE3, kedE3; enediyne biosynthesis protein E3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21161  sgcE3, ncsE3, kedE3; enediyne biosynthesis protein E3
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Others
   K21161  sgcE3, ncsE3, kedE3; enediyne biosynthesis protein E3

Genes

LANH:

KR767_19050

MSPN:

M8T91_09190

MAH:	MEALZ_1608

MBUR:

EQU24_12375

MEIN:

methR_P2296

TIG:

THII_0009

RUY:	NOR97_17050

HOH:

CSAC:

BHUI:

PCHI:

PCEL:

NBR:	O3I_023105

NTP:	CRH09_15830

NOZ:	DMB37_04385 DMB37_37210

NAH:	F5544_22890

NVU:	V7968_30885

SGR:	SGR_606(unbL2)

SGB:

SANL:

STRM:

SCLF:

SGS:	AVL59_07280 AVL59_19190

SPLU:

LK06_002480

STIR:

DDW44_31485

SGZ:	C0216_12035

SSPO:

DDQ41_31025

SSPB:

CP982_03190

SDRZ:

NEH16_31930

SGK:	PET44_34870

SFIY:

F0344_34695

SLAI:

P8A22_37575

SCAT:

P8A18_04010

AIL:	FLP10_09545

THAO:

NI17_008355

NEX:	NE857_19675

NCG:	KGD84_11520

ACTW:

F7P10_19180

ACIR:

OG979_40615

SPIQ:

OHA34_00385 OHA34_03985

SRO:	Sros_7002 Sros_8246

NOA:	BKM31_52780

NOW:	GBF35_43350

NCX:	Nocox_35700

NGN:	LCN96_24400 LCN96_48585

NFS:	OIE67_00425

BMON:

AMD:

AMN:

AMM:

AMZ:

AOI:

AJA:	AJAP_30295

AMYC:

CU254_17280

AMYB:

BKN51_01380

AAB:	A4R43_37065

AMYY:

AORI:

APRT:

AROO:

AMOG:

ACOR:

ANW:	QP939_27720

AMYE:

AMYS:

APRE:

AMI:

SESP:

SSYI:

EKG83_13170 EKG83_27960

KPHY:

AOZ06_31020

LED:	BBK82_30770

ACTI:

UA75_19100

ACAD:

UA74_18610

AHG:	AHOG_16615

ACTA:

C1701_26345

ALO:

CRK57501

ACTU:

Actkin_05266

UME:	RM788_41465

STP:	Strop_0592 Strop_2700

SAQ:	Sare_0550 Sare_2176

MAU:	Micau_2505

MIL:

MICB:

MICH:

MTEM:

MCAB:

VMA:	VAB18032_18410

MCRA:

ID554_11865 ID554_28110

VER:	HUT12_18875

MENO:

MCHL:

MPRN:

MCAY:

MICF:

ACTN:

AIH:	Aiant_18160

PLAB:

C6361_26125

PLAT:

C6W10_12725

PFLA:

Pflav_004970

PSUU:

Psuf_058070 Psuf_069990

PRY:	Prubr_36630

CCAZ:

COUCH_16295

CAI:	Caci_6358 Caci_6372

MAR:

MAE_12740

MPK:

VL20_1930

MIQ:	B5D77_13925

MVZ:	myaer102_46760

CYP:	PCC8801_2243

CYH:	Cyan8802_2295

CYJ:	Cyan7822_0305

NOP:	Nos7524_5239

NED:	HUN01_32975 HUN01_32980 HUN01_32985

NOSU:

JYQ62_10505 JYQ62_10510

RSIN:

B6N60_00272

HAU:

Haur_0869

AG:	AAM78015(ncsE3) AFV52142(kedE3)

» show all

Reference

PMID:12183628 (sgcE3)

Authors

Liu W, Christenson SD, Standage S, Shen B

Title

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

Science 297:1170-3 (2002)
DOI:10.1126/science.1072110

Sequence

[sgb:WQO_34005]

Reference

PMID:15797213 (ncsE3)

Authors

Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B

Title

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Journal

Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013

Sequence

[ag:AAM78015]

Reference

PMID:23360970 (kedE3)

Authors

Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B

Title

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.

Journal

Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a

Sequence

[ag:AFV52142]

LinkDB

DBGET integrated database retrieval system