KEGG ORTHOLOGY: K21162

ORTHOLOGY: K21162

Entry

K21162                      KO

Symbol

sgcE4, ncsE4, kedE4

Name

enediyne biosynthesis protein E4

Pathway

map01059

Biosynthesis of enediyne antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00824

9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21162  sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21162  sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Others
   K21162  sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4

Genes

LANH:

SWD:

SPSW:

SMAI:

SBK:	SHEWBE_3492

SAES:

SPSH:

SSEM:

ASP:

ASQ:	AVL57_16115

AAW:	AVL56_15035

ALE:	AV939_15055

ALZ:	AV940_14805

CATE:

C2869_12245

MSPN:

M8T91_09185

MAH:	MEALZ_1607

MBUR:

MEIN:

TIG:

TBN:

OME:	OLMES_1174

NEL:	NELON_06980

NEK:	CGZ77_07220

NBC:	H3L91_06290

NSG:	H3L94_10905

KOA:	H3L93_03755

KPOT:

ACRS:

NTU:

MESO:

OST:	ABWH87_10740

AMAX:

ABWH92_18580

AGC:	BSY240_2571

MMYR:

MXMO3_03300

HDI:

HDIA_0904

PPHR:

APZ00_08805

LAP:	ACP90_26890

LABP:

LABT:

LAGG:

RPOP:

RAGG:

SIW:	GH266_10865

SIT:	TM1040_3172

RUY:	NOR97_17055

RBL:	B6K69_15295

SEDI:

EBB79_03910

NSM:	JO391_18490

MAGQ:

MGMAQ_3276

MXA:

MXAN_7127

MYX:	QEG98_39865

MVH:	ACN6A1_01035

MYM:	A176_007407

PFLY:

VZL07_12470

CCX:	COCOR_00275

MFU:	LILAB_10760

MMAS:

MYMAC_006827

CEXI:

ACN6A2_16055

PPAK:

JY651_43780

AGE:	AA314_09928

AVM:	JQX13_09980

MBD:	MEBOL_002836

CFUS:

CYFUS_000466

HOH:	Hoch_0695 Hoch_4767

BDC:	DOE51_14115

HAX:	BALOs_2030

BSTO:

C0V70_15255

OBG:	Verru16b_02682

OBA:	ASA1KI_15660

ROO:	G5S37_27530

OSU:	NT6N_12070

RUL:	UC8_00560 UC8_56400

MFF:	MFFC18_36040

AHEL:

Q31a_61540

SMAM:

Mal15_28190

BGOK:

Pr1d_12790

PLS:	VT03_09290 VT03_11615

PLH:	VT85_13075

FMR:	Fuma_00958

GPN:	Pan110_18190

SCHL:

QJS52_09180 QJS52_21010

SSPE:

ACGY09_08790 ACGY09_20165

GES:	VT84_18135

GMS:	SOIL9_13590 SOIL9_20850

TIM:	GMBLW1_03800

LRS:	PX52LOC_00383

FTJ:

FTUN_8500

IPA:

Isop_2777

SACI:

Sinac_4841

PBOR:

BSF38_00095(bepA_1)

AGV:	OJF2_11840 OJF2_23250

PBAP:

Pla133_48350

PBU:	L21SP3_01326

UAM:	UABAM_06738

UHL:	UABHE_005656

ACA:

ACP_2236

GRB:	GOB94_06410

TRS:	Terro_2232 Terro_2596

ABAS:

ACPOL_0398 ACPOL_5886 ACPOL_5990

EPL:	P4G45_06575

ADIN:

H7849_12780

TGI:	RBB81_08725

TEMP:

TPSC:

SCOR:

CSAC:

NKO:	Niako_2674 Niako_6041

PSEG:

D3H65_12805

PGIN:

FRZ67_04365 FRZ67_15375

LACS:

H4075_17835 H4075_20840 H4075_20845

THEO:

IMW88_05195

HHY:	Halhy_1524

PGS:	CPT03_09745

MGIN:

FRZ54_16490

MGOS:

DIU38_012860

MGIK:

GO620_008500

CMR:	Cycma_3657 Cycma_3897

CAMU:

CA2015_0839 CA2015_3586 CA2015_3681 CA2015_3844

BBD:	Belba_0461

EVI:	Echvi_3749 Echvi_3895

EST:	DN752_02070 DN752_05225

ECHI:

FKX85_17670 FKX85_18300

ALM:	AO498_04980

MDA:	IPZ59_09705

SLI:	Slin_2472 Slin_5060

SMON:

AWR27_11905 AWR27_19270

SPIR:

CWM47_07785 CWM47_11610 CWM47_18010

SPIK:

EXU85_03415 EXU85_17765 EXU85_33540

SPIB:

G8759_00070 G8759_18655 G8759_35245

STAE:

HNV11_07615 HNV11_17315

SRHO:

HH216_03325

SOQ:	LQ777_22100

SFOL:

H3H32_09775

SENF:

GJR95_28080

RHOZ:

GXP67_07740 GXP67_08930 GXP67_13770 GXP67_16740 GXP67_20735 GXP67_24980 GXP67_35035

EOL:	Emtol_0737 Emtol_1627

ALS:	DJ013_11970 DJ013_14745 DJ013_17925

DFE:

Dfer_4738

DSN:	HWI92_04565 HWI92_07120 HWI92_13130

DYC:	NFI80_13525

RSI:	Runsl_1291 Runsl_3622 Runsl_4954

RUN:	DR864_07610 DR864_07655 DR864_15290 DR864_26505

RUP:	DTQ70_06750 DTQ70_26635

FAE:	FAES_0977 FAES_0980 FAES_1481

FIB:	A6C57_09275

ADD:	HUW48_01240 HUW48_02550 HUW48_22995

ASWU:

HUW51_01505 HUW51_10045 HUW51_19315 HUW51_24270

MTT:	Ftrac_0134 Ftrac_0135 Ftrac_2883

CHK:	D4L85_16985 D4L85_24715

GFO:	GFO_1031 GFO_1032

GRL:	LPB144_04700 LPB144_04705

GFL:	GRFL_2257 GRFL_2911

GRS:	C7S20_07550 C7S20_10150

FBR:	FBFL15_0543

ZPR:	ZPR_2446 ZPR_2447

FBC:	FB2170_04730 FB2170_08149

MARM:

YQ22_01985 YQ22_09430 YQ22_10505 YQ22_11730 YQ22_14740

MART:

BTR34_06310 BTR34_09505 BTR34_10430 BTR34_14625

MARB:

CJ263_04720

CAO:	Celal_0757 Celal_0778 Celal_2460

CLH:	IX49_14720

CBAT:

M666_02795 M666_04230

DOK:	MED134_10810 MED134_12346

DDO:

I597_1250

ZGA:	ZOBELLIA_1260 ZOBELLIA_2087 ZOBELLIA_4697

ZLA:	Q5W13_23730

NOB:	CW736_08115

POM:	MED152_05145

PRN:	BW723_03895

PBAT:

JL193_03930

WIN:	WPG_0787 WPG_1883 WPG_1884

SYI:	SB49_09975

TJE:	TJEJU_2843

LUL:	LPB138_07675 LPB138_13040 LPB138_13045 LPB138_13050

SALT:

AO058_07350 AO058_14845

SMIS:

LDL76_11645

AALG:

AREALGSMS7_00944

FEK:	C1H87_08895 C1H87_09565 C1H87_18455

AUE:	C5O00_07625 C5O00_07635

AQB:	D1818_04615 D1818_17175 D1818_17180 D1818_17360 D1818_19830

AQA:	D1815_14240 D1815_14250

AQD:	D1816_02860 D1816_09205 D1816_20030

EMAR:

D1013_18355 D1013_18360

MUR:	EQY75_04385

MESQ:

C7H62_1886

GAA:	HX109_04340 HX109_04350 HX109_09280 HX109_11785

CAGG:

HYG79_03095 HYG79_10380

LPAL:

LDL79_13905

SINH:

LS482_01115 LS482_12460 LS482_16540

ASAG:

FGM00_00345 FGM00_05775 FGM00_15570

FLG:	LV716_10065

MRS:	Murru_0556 Murru_0565 Murru_0954 Murru_0956 Murru_2282

MLT:	VC82_1044 VC82_2565 VC82_940

MAQI:

LDL77_16855

SPON:

HME9304_01072

SABU:

MBM09_14235

FBE:	FF125_03925

CRM:	K6119_04955 K6119_05845

RMR:

CPRV:

BHUI:

PCEL:

NBR:	O3I_023110 O3I_032495

NTP:	CRH09_15800

NOZ:	DMB37_04390 DMB37_37125 DMB37_37215

NAH:	F5544_22895

NWL:	NWFMUON74_34970

NIE:	KV110_31480

NGP:	LTT66_22020

NSPU:

IFM12276_12620

NVU:	V7968_30890 V7968_40305

SGR:	SGR_607(unbV)

SGB:

SANL:

STRM:

SCLF:

SGS:	AVL59_07285 AVL59_19220

SPLU:

LK06_002515

STIR:

DDW44_31480

SGZ:	C0216_12040

SSPO:

DDQ41_31020

SSPB:

CP982_03195

SDRZ:

NEH16_31925

SGK:	PET44_34875

SFIY:

SLAI:

SCAT:

SSEC:

KIC:	KCMC57_up60100

RIA:	C7V51_07080

AIL:	FLP10_09550

IHA:	UQW22_05090

THAO:

NI17_008180

NEX:	NE857_19545

NCG:	KGD84_11605

SNAH:

OUQ99_16600

ACTW:

F7P10_19175

ACIR:

OG979_40610

AWS:	ACN3XK_05345 ACN3XK_05385 ACN3XK_67980

SPIQ:

OHA34_00400 OHA34_03980

SRO:	Sros_7001 Sros_8247

NGN:	LCN96_24405

BMON:

AMD:

AMN:

AMM:

AMZ:

AOI:

AJA:	AJAP_30290

AMYC:

CU254_17285

AMYB:

BKN51_01385

AAB:	A4R43_37070

AMYY:

AORI:

APRT:

AROO:

AMOG:

ACOR:

ANW:	QP939_27725

AMYE:

MJQ72_31865

AMYS:

CVV72_19915

APRE:

CNX65_20590 CNX65_20615

AMI:	Amir_4112 Amir_4117

SESP:

BN6_39250

SSYI:

EKG83_13105 EKG83_13165 EKG83_13175 EKG83_28010 EKG83_28035

KPHY:

AOZ06_31060

LXR:	ACRSBM_21170

ACTI:

UA75_19095

ACAD:

UA74_18605

AHG:	AHOG_16610

ACTA:

ACAU:

ALO:

ACTU:

UME:	RM788_41430

STP:	Strop_0593 Strop_2699

SAQ:	Sare_0555 Sare_2177

MAU:	Micau_2506

MIL:

MICB:

MICH:

MTEM:

MCAB:

VMA:	VAB18032_18440

MCRA:

ID554_11870 ID554_28165

VER:	HUT12_18820

MENO:

MCHL:

MPRN:

MCAY:

MICF:

MICN:

VET:	ACQVFL_14455 ACQVFL_19205

ACTN:

L083_3235

AIH:	Aiant_18110

PLAB:

C6361_26120

PLAT:

C6W10_12730

PFLA:

Pflav_004980

PSUU:

Psuf_058060 Psuf_070030

PRY:	Prubr_36640

CCAZ:

COUCH_16290

CAI:

Caci_6360

WNA:	KA717_09045

LEPT:

JVX88_01165

MAR:

MAE_12730

MPK:

VL20_1931

MIQ:	B5D77_13930

MVZ:	myaer102_46750

CYJ:	Cyan7822_0306

OXY:	HCG48_05805

GML:	ISF26_08935

NOP:	Nos7524_5240

RSIN:

B6N60_00271

NSPH:

BDGGKGIB_04550(rsxD)

TOI:	HG267_25355

TOZ:	HGR01_29210

HAU:	Haur_0868 Haur_0870

CAP:	CLDAP_05470 CLDAP_19960

CCZ:	CCALI_01314

MTAI:

Mtai_v1c12090

HRR:	HZS55_21630

HPEL:

HZS54_25095

HLT:	I7X12_14995

HALP:

DOS48_11570

AG:	AAM78014(ncsE4) AFV52141(kedE4)

» show all

Reference

PMID:12183628 (sgcE4)

Authors

Liu W, Christenson SD, Standage S, Shen B

Title

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

Science 297:1170-3 (2002)
DOI:10.1126/science.1072110

Sequence

[sgb:WQO_34000]

Reference

PMID:15797213 (ncsE4)

Authors

Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B

Title

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Journal

Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013

Sequence

[ag:AAM78014]

Reference

PMID:23360970 (kedE4)

Authors

Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B

Title

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.

Journal

Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a

Sequence

[ag:AFV52141]

LinkDB

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