KEGG ORTHOLOGY: K21165

ORTHOLOGY: K21165

Entry

K21165                      KO

Symbol

sgcE8, ncsE8, kedE8

Name

enediyne biosynthesis protein E8

Pathway

map01059

Biosynthesis of enediyne antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00824

9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21165  sgcE8, ncsE8, kedE8; enediyne biosynthesis protein E8
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21165  sgcE8, ncsE8, kedE8; enediyne biosynthesis protein E8
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Others
   K21165  sgcE8, ncsE8, kedE8; enediyne biosynthesis protein E8

Genes

SGR:

SGB:

STRM:

SPLU:

STIR:

SGZ:	C0216_12080

SSPO:

DDQ41_30970

SFY:	GFH48_34880

SBAT:

G4Z16_02205

SLON:

LGI35_02870

SDRZ:

NEH16_31885

SGK:	PET44_34915

SFIY:

SRPZ:

PPOD:

AGLA:

IHA:	UQW22_05070

THAO:

NI17_008345

NEX:	NE857_19665

NEC:	KGD82_07405

AWS:	ACN3XK_66360

SRO:

Sros_6993

NGN:	LCN96_24445

AMD:

AMN:

AMM:

AMZ:

AOI:

AJA:	AJAP_30275

AMYB:

BKN51_01400

AAB:	A4R43_37085

AMYY:

AORI:

APRT:

AROO:

AMOG:

ACOR:

AMYE:

AMYS:

SESP:

KPHY:

LXR:	ACRSBM_21140

ACTI:

UA75_19105

ACAD:

UA74_18615

AHG:	AHOG_16620

ACTA:

C1701_26350

ACAU:

ACOJVX_11610

ACTU:

Actkin_03733

UME:	RM788_41300

STP:	Strop_2705

SAQ:

Sare_0547

MTEM:

GCE86_07980

VMA:	VAB18032_18420

MPRN:

Q3V37_18515

MCAY:

PVK37_23055

MICN:

WHN02_17015

VET:	ACQVFL_19250

ACTN:

L083_3205

AIH:	Aiant_18230

PLAB:

PLAT:

PFLA:

PSUU:

CAI:

AG:	AAM78006(ncsE8) AFV52136(kedE8)

» show all

Reference

PMID:12183628 (sgcE8)

Authors

Liu W, Christenson SD, Standage S, Shen B

Title

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

Science 297:1170-3 (2002)
DOI:10.1126/science.1072110

Sequence

[sgb:WQO_33965]

Reference

PMID:15797213 (ncsE8)

Authors

Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B

Title

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Journal

Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013

Sequence

[ag:AAM78006]

Reference

PMID:23360970 (kedE8)

Authors

Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B

Title

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.

Journal

Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a

Sequence

[ag:AFV52136]

LinkDB

DBGET integrated database retrieval system