KEGG ORTHOLOGY: K21166

ORTHOLOGY: K21166

Entry

K21166                      KO

Symbol

sgcE9, ncsE9, kedE9

Name

enediyne biosynthesis protein E9

Pathway

map01059

Biosynthesis of enediyne antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00824

9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21166  sgcE9, ncsE9, kedE9; enediyne biosynthesis protein E9
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21166  sgcE9, ncsE9, kedE9; enediyne biosynthesis protein E9
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Others
   K21166  sgcE9, ncsE9, kedE9; enediyne biosynthesis protein E9

Other DBs

COG:

COG2303

Genes

SGR:

SGB:

STRM:

SPLU:

STIR:

SGZ:	C0216_12085

SSPO:

DDQ41_30965

SFY:	GFH48_34885

SBAT:

G4Z16_02210

SLON:

LGI35_02875

SDRZ:

NEH16_31880

SGK:	PET44_34920

SFIY:

F0344_34740

AGLA:

OIE69_05235

THAO:

NI17_008340

NEX:	NE857_19660

SRO:

Sros_6992

NGN:	LCN96_24450

AMD:

AMN:

AMM:

AMZ:

AOI:

AJA:	AJAP_30270

AMYB:

BKN51_01405

AAB:	A4R43_37090

AMYY:

YIM_40995(choA2)

AORI:

APRT:

AROO:

SESP:

KPHY:

ACTI:

ACAD:

AHG:	AHOG_16625(choA)

ACTA:

C1701_26355

ALO:

CRK57510

ACTU:

Actkin_03734(choD_1)

UME:	RM788_41295

STP:	Strop_2704

SAQ:

Sare_0546

MICH:

FJK98_15620

MTEM:

GCE86_07985

VMA:	VAB18032_18425

MPRN:

Q3V37_18510

ACTN:

L083_3206

AIH:	Aiant_18240

PLAB:

PLAT:

PFLA:

PSUU:

CAI:

AG:	AAM78005(ncsE9) AFV52135(kedE9)

» show all

Reference

PMID:12183628 (sgcE9)

Authors

Liu W, Christenson SD, Standage S, Shen B

Title

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

Science 297:1170-3 (2002)
DOI:10.1126/science.1072110

Sequence

[sgb:WQO_33960]

Reference

PMID:15797213 (ncsE9)

Authors

Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B

Title

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Journal

Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013

Sequence

[ag:AAM78005]

Reference

PMID:23360970 (kedE9)

Authors

Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B

Title

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.

Journal

Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a

Sequence

[ag:AFV52135]

LinkDB

DBGET integrated database retrieval system