KEGG ORTHOLOGY: K21167

ORTHOLOGY: K21167

Entry

K21167                      KO

Symbol

sgcE11, ncsE11, kedE11

Name

enediyne biosynthesis protein E11

Pathway

map01059

Biosynthesis of enediyne antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00824

9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21167  sgcE11, ncsE11, kedE11; enediyne biosynthesis protein E11
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21167  sgcE11, ncsE11, kedE11; enediyne biosynthesis protein E11
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Others
   K21167  sgcE11, ncsE11, kedE11; enediyne biosynthesis protein E11

Genes

SGR:

SGB:

STRM:

SPLU:

STIR:

SGZ:	C0216_12095

SSPO:

DDQ41_30960

SDRZ:

NEH16_31870

SGK:	PET44_34930

SFIY:

SLAI:

SCAT:

SSEC:

LINS:

IHA:	UQW22_05030

THAO:

NI17_008330

NEX:	NE857_19650

NEC:	KGD82_07420

AWS:	ACN3XK_66375

SRO:

Sros_6990

NGN:	LCN96_24460

AMD:

AMN:

AMM:

AMZ:

AOI:

AJA:	AJAP_04335

AMYB:

BKN51_27975

AAB:	A4R43_37110

AMYY:

AORI:

APRT:

AROO:

AMOG:

ACOR:

ANW:	QP939_27755

AMYE:

AMYS:

SESP:

KPHY:

LXR:	ACRSBM_21095

ACTI:

UA75_19055

ACAD:

UA74_18565

AHG:	AHOG_16565

ACTA:

C1701_26295

ACAU:

ACOJVX_11665

ACTU:

Actkin_05224

UME:	RM788_41535

STP:	Strop_2706

SAQ:

Sare_0559

MTEM:

GCE86_07990

VMA:	VAB18032_18405

MPRN:

Q3V37_18465

MCAY:

PVK37_23070

MICN:

WHN02_16995

VET:	ACQVFL_19245

ACTN:

L083_3208

AIH:	Aiant_18210

PLAB:

PLAT:

PFLA:

PSUU:

CAI:

AG:	AAM78004(ncsE11) AFV52131(kedE11)

» show all

Reference

PMID:12183628 (sgcE11)

Authors

Liu W, Christenson SD, Standage S, Shen B

Title

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

Science 297:1170-3 (2002)
DOI:10.1126/science.1072110

Sequence

[sgb:WQO_33950]

Reference

PMID:15797213 (ncsE11)

Authors

Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B

Title

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Journal

Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013

Sequence

[ag:AAM78004]

Reference

PMID:23360970 (kedE11)

Authors

Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B

Title

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.

Journal

Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a

Sequence

[ag:AFV52131]

LinkDB

DBGET integrated database retrieval system