KEGG   ORTHOLOGY: K21186
Entry
K21186                      KO                                     
Symbol
sgcC5, mdpC5, kedY5
Name
condensation enzyme
Pathway
map01059  Biosynthesis of enediyne antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21186  sgcC5, mdpC5, kedY5; condensation enzyme
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21186  sgcC5, mdpC5, kedY5; condensation enzyme
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21186  sgcC5, mdpC5, kedY5; condensation enzyme
Other DBs
COG: COG1020
Genes
HAXI: HAALTHF_51210n
NVU: V7968_29200
SGB: WQO_33875
STRM: M444_37890
SALW: CP975_03615
SPLU: LK06_002650
SFK: KY5_0738c
STIR: DDW44_31365
SKA: CP970_39315
SSPO: DDQ41_30920
SRO: Sros_6976
AMYY: YIM_40805(lgrB10)
SESP: BN6_39030(nrps6-c)
ACTI: UA75_18100
ACAD: UA74_17575
AHG: AHOG_16495(lgrB)
ALO: CRK59437
ACTU: Actkin_05236(lgrB_3)
SAQ: Sare_2097
AG: ABY66007(mdpC5) AFV52192(kedY5)
 » show all
Reference
PMID:12183628 (sgcC5)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33875]
Reference
  Authors
Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B
  Title
Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis.
  Journal
Org Lett 14:2300-3 (2012)
DOI:10.1021/ol300720s
Reference
PMID:17918933 (mdpC5)
  Authors
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
  Title
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
  Journal
J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o
  Sequence
Reference
PMID:23633564 (kedY5)
  Authors
Huang SX, Lohman JR, Huang T, Shen B
  Title
A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway.
  Journal
Proc Natl Acad Sci U S A 110:8069-74 (2013)
DOI:10.1073/pnas.1304733110
  Sequence
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