KEGG   ORTHOLOGY: K21256
Entry
K21256                      KO                                     
Symbol
calO3
Name
flavin-dependent halogenase
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00833  Calicheamicin biosynthesis, calicheamicinone => calicheamicin
M00834  Calicheamicin orsellinate moiety biosynthesis, malonyl-CoA => orsellinate-ACP => 5-iodo-2,3-dimethoxyorsellinate-ACP
Reaction
R11414  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21256  calO3; flavin-dependent halogenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21256  calO3; flavin-dependent halogenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Halogenase
   K21256  calO3; flavin-dependent halogenase
Other DBs
COG: COG0644
Genes
PBRE: QDY63_14350
SFIY: F0344_35050
AMOG: QRX60_51085
ANW: QP939_27925
SAQ: Sare_2031
AG: AAM70353(calO3)
Reference
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
Reference
  Authors
McCoy JG, Johnson HD, Singh S, Bingman CA, Lei IK, Thorson JS, Phillips GN Jr
  Title
Structural characterization of CalO2: a putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway.
  Journal
Proteins 74:50-60 (2009)
DOI:10.1002/prot.22131
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