KEGG   ORTHOLOGY: K21260
Entry
K21260                      KO                                     
Symbol
calG2
Name
calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase [EC:2.4.1.-]
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00833  Calicheamicin biosynthesis, calicheamicinone => calicheamicin
Reaction
R11418  dTDP-4-deoxy-4-thio-alpha-D-digitoxose:calicheamicin-T0 4-deoxy-4-thio-alpha-D-digitoxosyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21260  calG2; calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21260  calG2; calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Glycosyltransferase
   K21260  calG2; calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase
Other DBs
COG: COG1819
CAZy: GT1
Genes
SAQ: Sare_2036
AG: AAM70348(calG2)
Reference
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
Reference
  Authors
Zhang C, Bitto E, Goff RD, Singh S, Bingman CA, Griffith BR, Albermann C, Phillips GN Jr, Thorson JS
  Title
Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis.
  Journal
Chem Biol 15:842-53 (2008)
DOI:10.1016/j.chembiol.2008.06.011
LinkDB

KEGG   REACTION: R11418
Entry
R11418                      Reaction                               
Name
dTDP-4-deoxy-4-thio-alpha-D-digitoxose:calicheamicin-T0 4-deoxy-4-thio-alpha-D-digitoxosyltransferase
Definition
dTDP-4-deoxy-4-thio-alpha-D-digitoxose + Calicheamicin T0 <=> dTDP + 4-Deoxy-4-thio-alpha-D-digitoxosyl-calicheamicin T0
Equation
Reaction class
RC00005  C00363_C21349
RC03434  C21338_C21339
Enzyme
2.4.1.-
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00833  Calicheamicin biosynthesis, calicheamicinone => calicheamicin
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.-
     R11418  dTDP-4-deoxy-4-thio-alpha-D-digitoxose + Calicheamicin T0 <=> dTDP + 4-Deoxy-4-thio-alpha-D-digitoxosyl-calicheamicin T0
Orthology
K21260  calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase [EC:2.4.1.-]
LinkDB

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