KEGG ORTHOLOGY: K21267

ORTHOLOGY: K21267

Entry

K21267                      KO

Symbol

iri, rox

Name

rifampicin monooxygenase [EC:1.14.13.211]

Reaction

R11151

rifampicin:NADH:oxygen oxidoreductase (2-hydroxy-2,27-secorifampicin-forming; ring-cleaving)

R11152

rifampicin:NADPH:oxygen oxidoreductase (2'-N-hydroxyrifampicin-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K21267  iri, rox; rifampicin monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.211  rifampicin monooxygenase
     K21267  iri, rox; rifampicin monooxygenase
Antimicrobial resistance genes [BR:ko01504]
Gene variants
  Rifamycin resistance genes
   Oxygenases
    K21267  iri, rox; rifampicin monooxygenase

Other DBs

COG:

COG0654

Genes

LMB:	C9I47_1848

RHJ:	HZY79_00590

PPAK:

JY651_18035(rox)

PBRU:

LZC95_51745

PRUE:

LVJ94_51285

PALJ:

LZC94_20335(rox) LZC94_46870

MMC:

Mmcs_2661

MKM:

Mkms_2706

MJL:

Mjls_2691

MYV:	G155_10900

MSM:	MSMEG_2252

MSG:	MSMEI_2197

MSB:	LJ00_11210

MSN:	LI99_11210

MSH:	LI98_11215

MCB:	Mycch_0828

MFT:	XA26_22420

MTHN:

4412656_04597(pcpB_2)

MCHT:

MCHIJ_38720

MMON:

EWR22_14160(rox)

MFLU:

HZU40_19920(rox)

MYH:	QU592_10490(rox)

ASD:

AS9A_2324

NFA:	NFA_35380(rox)

NFR:	ERS450000_00511(pcpB_1)

NBR:	O3I_020820

NNO:	NONO_c65020

NSL:	BOX37_12060

NSR:	NS506_05823

NTP:	CRH09_14830

NOZ:	DMB37_35700 DMB37_35980(rox)

NOD:	FOH10_14330(rox)

NAH:	F5544_22005(rox) F5544_22150(rox)

NAD:	NCTC11293_02478(pcpB_3) NCTC11293_04330(pcpB_5)

NHU:	H0264_27360(rox)

NYA:	LTV02_10235(rox)

NGP:	LTT66_29350(rox)

NSPU:

IFM12276_29920

NYU:	D7D52_23110(rox)

NVU:	V7968_14860 V7968_28630

RHA:	RHA1_ro07160

RER:

RER_20250

REY:

O5Y_09730

REB:	XU06_09965

RQI:	C1M55_10225(iri)

ROP:

ROP_37320

ROA:	Pd630_LPD03904

RAV:	AAT18_01260

RRZ:	CS378_17530

RCR:	NCTC10994_00474(pcpB)

RTM:	G4H71_05850(rox)

RKO:	JWS14_00845(rox) JWS14_21170(rox)

RGO:	KYT97_23045(iri)

ROZ:	CBI38_15390

RPSK:

JWS13_23710(rox) JWS13_45025(rox)

RHOO:

RA302_10105(iri)

RHOU:

KZJ41_01295(rox)

RHOW:

A4U64_23455

RHOJ:

JVH1_00685(rox)

RHOS:

QWW67_18660(rox)

RHOQ:

QWW98_18670(rox)

RHOY:

QNA09_25405(rox)

RHOH:

CPI83_19095

RHJS:

OYT95_00395(rox)

RHZQ:

GO592_14190(rox)

RHBH:

A0W34_10070

RHON:

EHW12_10120(iri)

RHWB:

FND50_17900(rox)

RHSQ:

E7742_16315(rox)

RHWY:

GFS60_03217

RHDM:

HFP48_01365(rox)

RHMM:

ISO16_18605(rox)

RHZP:

HYG77_31255(rox)

RHRC:

P0M12_22485(iri)

RHNY:

ACBG85_10105(iri)

REQ:

REQ_41440

PSOW:

ABI214_01825

GOM:	D7316_01072(otcC)

SCO:	SCO7626(SC2H2.24c)

SALB:

XNR_3358

SFI:

SFUL_1083

SCB:	SCAB_86061 SCAB_87811

SHY:

SHJG_0647

SHO:	SHJGH_0480

SRC:	M271_08430

SBH:

SBI_09593

SVE:

SVEN_0481

SLV:	SLIV_01185

SGU:	SGLAU_30650

SVT:	SVTN_01150 SVTN_31975

SLD:

T261_4795

SLC:	SL103_19710

STRM:

M444_16460

STRC:

AA958_04415

SPRI:

SPRI_0130 SPRI_7223

SCZ:	ABE83_30235

SCX:	AS200_01595 AS200_42295 AS200_44240

SRW:	TUE45_01151(pcpB_1)

SPAV:

Spa2297_00880

SCLF:

BB341_28050

SKY:	D0C37_14590(rox)

SALW:

CP975_16240(rox)

SGM:	GCM10017557_73960 GCM10017557_80250 GCM10017557_82510

SCAD:

DN051_36265(rox)

SPHW:

NFX46_24900

SGRS:

V9K83_01100(rox)

STRD:

NI25_36215

SGV:	B1H19_19290

SALF:

SMD44_07122

SALJ:

SMD11_6238 SMD11_6656

SLX:	SLAV_11085(pcpB4)

STRO:

STRMOE7_35915

SFK:

KY5_0184

SGE:	DWG14_01874(otcC_2) DWG14_06120(otcC_4)

SRJ:

SRO_6922

SLK:	SLUN_18280

SGD:	ELQ87_04590(rox)

SCYA:

EJ357_38800(rox)

SNQ:	CP978_28085(rox)

STIR:

DDW44_23910(rox)

SKA:	CP970_36715 CP970_42000(rox)

SGZ:	C0216_15010

SVN:	CP980_05055(rox)

SRK:	FGW37_01015(rox)

SFIC:

EIZ62_19545(rox)

SSPO:

DDQ41_28065(rox)

SPAD:

DVK44_19705

SFY:	GFH48_27575(rox)

SGF:	HEP81_07258

SCAV:

CVT27_04410

SSEO:

D0Z67_04825(rox)

SBY:	H7H31_19150

SRIM:

CP984_11965(rox)

SSUB:

CP968_26650(rox)

SPHV:

F9278_01720(rox)

SCIN:

CP977_05620

STSU:

B7R87_08145

SCHA:

CP983_06175(rox)

SGX:	H4W23_38295(rox)

SBAT:

G4Z16_11275(rox)

SNF:	JYK04_00573(otcC_3) JYK04_00810(otcC_4)

SPLA:

CP981_36700(rox)

SATA:

C5746_22555

SHUN:

DWB77_00315(otcC_1) DWB77_07437(otcC_8)

SFEU:

IM697_28010(rox) IM697_28330(rox)

SLIA:

HA039_18840(rox)

SDW:	K7C20_21610(rox)

SVD:	CP969_12535(rox)

SAUH:

SU9_002615(rox)

SMOB:

J7W19_03885(rox)

SPRA:

CP972_16765(rox)

SPEU:

CGZ69_33670

SINE:

KI385_00320(rox)

SLF:	JEQ17_20780(rox) JEQ17_46830(rox)

SDEC:

L3078_02060(rox)

SAOV:

G3H79_04805(rox)

SDUR:

M4V62_36675(rox)

SRUG:

F0345_15785(rox)

SAKB:

K1J60_43335(rox)

STAA:

LDH80_07250(rox)

SNIG:

HEK616_75140

SVIO:

HWN34_17160(rox)

SCAE:

IHE65_43335(rox)

SXT:	KPP03845_100623(otcC)

SLON:

LGI35_40485(rox)

SDRZ:

NEH16_30110 NEH16_30145

STUD:

STRTU_005099 STRTU_006113

SENG:

OJ254_23605(rox)

SGK:	PET44_15180(rox)

SJN:	RI060_16530(rox)

SFIY:

F0344_00610(rox)

SHAU:

K9S39_25475

SCOA:

QU709_36985 QU709_44865(rox)

SLAI:

P8A22_17835(rox)

SFP:	QUY26_06510(rox)

STRZ:

OYE22_18745

SCAY:

PYS65_19545(rox)

SARM:

DVA86_25130(rox)

SLUO:

PS467_01690(rox)

STPB:

QR97_12040

SRPA:

HEP86_39035(rox)

SMIB:

SMIR_18255 SMIR_20210(rox)

SCAJ:

O1G22_43165(rox)

STRW:

QHG49_02240(rox)

STRL:

HEP84_24650(rox) HEP84_26845

STSD:

HEP87_25615(rox) HEP87_27815

SRPZ:

HEP85_13530(rox) HEP85_21230

SCHE:

QRN89_30910(rox)

STII:

DRB96_07560(rox)

STIC:

DRB89_04735(rox)

SABD:

N8I86_05510(rox)

SMOD:

POD33_33830(rox)

SPOF:

P8A21_06955

STBR:

ABDE16_36555

SSOC:

ABZO31_33315(rox)

SSLI:

R2D22_35460(rox)

SSIR:

WAB15_04490(rox)

STRJ:

H7827_09915 H7827_09925

SEXP:

SLV14_005021(rox)

SFLU:

ACKTSN_06290(rox)

SSTO:

ACE1OC_01910(rox)

STCM:

SCMC78_63420(rox)

STID:

G7Z12_23380(rox)

STCZ:

JHY03_10000

STSG:

B6R96_35215

STHU:

M1P56_13215(rox) M1P56_15195(rox)

SSEC:

ABZO29_42770(rox)

SHUG:

ABVG11_22265(rox)

STRK:

R2B38_03040(rox) R2B38_43130

KSK:

KSE_07580

KAB:	B7C62_04415

KIT:	CFP65_0086

KIS:	HUT16_02905

KCH:	O1G21_00235(rox) O1G21_22125

KCM:	ABWK59_04795(rox)

KNB:	ACF9IK_31725 ACF9IK_34335(rox)

KIC:	KCMC57_up59560(rox)

KPUR:

ACFCLZ_08080

STRI:

C7M71_013320(rox)

YIA:	LO772_01570(rox) LO772_34465

STRH:

GXP74_26755(rox)

AGLA:

OIE69_33595(rox)

AREV:

RVR_2909 RVR_8886

LSE:	F1C12_20910

LEIZ:

IT072_14805

MWA:	E4K62_09675

MCAW:

F6J84_06195

MLZ:	F6J85_09290

MJI:	QNO14_05045(rox)

MWN:	QNO26_10005(rox)

MVD:	AWU67_08055

SALD:

FVA74_05230

PLAP:

EAO79_07025

PFLU:

BWO91_03180

HEA:	HL652_14235

ART:

Arth_1940

ARE:	AL755_21720

ARW:	MB46_12895

ARQ:	BWQ92_15450

AJG:	KKR91_06395

ACAO:

NF551_06570

AKO:	N9A08_06510

AJR:	N2K98_06675(rox)

ARTU:

E7Y32_15850(rox)

ARTL:

ArtHe_04235

KFV:	AS188_07380

BKI:	M4486_02155

BHH:	Bra3105_00415

IHA:	UQW22_03315(rox)

PROZ:

ACO229_05255(rox)

CDON:

KKR89_04035

CWAN:

KG103_04260

CFEN:

KG102_02750(rox)

KNO:	V6K52_00960

NDK:	I601_2824(pcpB)

NMES:

H9L09_10960(rox)

NPC:	KUV85_07115

SGRG:

L0C25_18795(rox) L0C25_21785(rox)

KFL:

Kfla_1528

KQI:	F1D05_12920(rox) F1D05_27825(rox)

KSL:	OG809_31735(rox)

KRI:	OX958_19010(rox)

TFU:

Tfu_2841

THAO:

NI17_007430(rox)

TALX:

FOF52_15240(rox)

NDA:

Ndas_2748

NGV:	CDO52_19475

NCG:	KGD84_14630(rox)

NOCB:

UIS43_07395(rox)

SNAH:

OUQ99_22100(rox)

AMAZ:

LUW76_12925(rox) LUW76_38440(rox)

ACIR:

OG979_38770(rox)

AWS:	ACN3XK_07195(rox) ACN3XK_07200 ACN3XK_29585(rox) ACN3XK_30560(rox) ACN3XK_68750 ACN3XK_69305

SRO:

Sros_4669

NOA:	BKM31_47680

NOW:	GBF35_25415(rox)

NCX:	Nocox_22045(pcpB2) Nocox_33465(pcpB6)

NGN:	LCN96_27720 LCN96_32520(rox)

NFS:	OIE67_19335

MHAI:

OHB01_29390(rox)

FRE:	Franean1_4133

FRI:	FraEuI1c_3695

SEN:

SACE_4643

SACG:

FDZ84_31035(rox)

SACC:

EYD13_11195(pcpB2)

AMD:

AMN:

AMM:

AMZ:

AOI:	AORI_3930(mhpA)

AJA:	AJAP_19340

AMYC:

CU254_15995 CU254_19080

AMYB:

BKN51_12065 BKN51_12125

AAB:	A4R43_00220 A4R43_03555

AMYY:

YIM_09330(pcpB1) YIM_16465(pcpB3)

AORI:

SD37_20160

APRT:

MUY14_42755(rox)

AROO:

NQK81_02955(rox)

ATHM:

L1857_07040(rox)

ARHD:

VSH64_45065(rox)

AMOG:

QRX60_35820(rox)

ACYN:

ORV05_12545(rox)

ACOR:

LCL61_25140(rox)

AMYZ:

HUW46_05776(otcC_4) HUW46_08497(otcC_13)

ACAB:

QRX50_00230(rox)

ANW:	QP939_02725(rox) QP939_42135(rox)

AMYD:

K1T34_25855(rox)

AMYE:

MJQ72_08630(rox)

AMYS:

PDX:

PSEE:

PSEQ:

PECQ:

PAUT:

PPEL:

H6H00_02695(rox)

APRE:

CNX65_10055

AMI:

Amir_2013

SESP:

BN6_42360 BN6_44160

SSYI:

EKG83_16990(rox)

KAL:

KALB_4274

KUT:	JJ691_25120 JJ691_73520

KPHY:

AOZ06_27820

LED:	BBK82_36645 BBK82_39920

LXR:	ACRSBM_15050 ACRSBM_32190(rox)

ACTI:

ACAD:

ALO:

PMAD:

SACE:

GIY23_21205(rox)

ACTU:

Actkin_03072(pcpB_3) Actkin_04232(pcpB_4)

AAUR:

V5P93_002933(rox)

CROS:

N8J89_13815(rox) N8J89_17625(rox) N8J89_20295

UME:	RM788_51935(rox)

STP:	Strop_1498

MAU:	Micau_0723

MIL:

ML5_0967

MICB:

MicB006_0754

MTUA:

CSH63_20890

MICH:

FJK98_20740 FJK98_25315(rox)

MTEM:

GCE86_10990(rox)

MCAB:

HXZ27_08900(rox)

MSAG:

GCM10017556_36290

VMA:	VAB18032_19300

VER:	HUT12_17995(rox)

MENO:

Jiend_13080

MCHL:

PVK74_24860(rox)

MPRN:

Q3V37_28625(rox)

MHAW:

RMN56_18980(rox) RMN56_19555(rox)

MCAY:

PVK37_15755(rox) PVK37_22040(rox)

MICF:

QQG74_07665(rox)

ASE:

ACPL_5566

AMS:	AMIS_39810

ACTN:

L083_3384

ACTS:

ACWT_5436

AIH:	Aiant_03400

ACTR:

Asp14428_10770

ACTL:

L3i22_057780

ASIC:

Q0Z83_023790(rox) Q0Z83_032510

AOU:	ACTOB_005272(rox) ACTOB_005474

AFS:	AFR_14665 AFR_21600

PLAB:

C6361_21750

PLAT:

C6W10_16710

PSUU:

Psuf_073720

ATL:	Athai_28500 Athai_60150

ASER:

Asera_46090

PRY:	Prubr_19000

CATI:

CS0771_48580

DVC:	Dvina_10845 Dvina_22025(rox)

DFU:	Dfulv_36030(rox)

DROS:

Drose_13170(rox)

DAUR:

Daura_18630(rox) Daura_28680 Daura_31715(rox)

DMAT:

Dmats_10440 Dmats_17640(rox)

DACT:

KZZ52_24555(rox)

SNA:

Snas_3217

JAT:	SAMN05892883_4143

CWO:

Cwoe_4431

AG:	AAB41059(iri)

» show all

Reference

PMID:8980786

Authors

Andersen SJ, Quan S, Gowan B, Dabbs ER

Title

Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic.

Journal

Antimicrob Agents Chemother 41:218-21 (1997)
DOI:10.1128/AAC.41.1.218

Sequence

[ag:AAB41059]

Reference

PMID:19942945

Authors

Hoshino Y, Fujii S, Shinonaga H, Arai K, Saito F, Fukai T, Satoh H, Miyazaki Y, Ishikawa J

Title

Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance.

Journal

J Antibiot (Tokyo) 63:23-8 (2010)
DOI:10.1038/ja.2009.116

Sequence

[nfa:NFA_35380]

Reference

PMID:29398560

Authors

Koteva K, Cox G, Kelso JK, Surette MD, Zubyk HL, Ejim L, Stogios P, Savchenko A, Sorensen D, Wright GD

Title

Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.

Journal

Cell Chem Biol 25:403-412.e5 (2018)
DOI:10.1016/j.chembiol.2018.01.009

Sequence

[sve:SVEN_0481]

LinkDB

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