KEGG   ORTHOLOGY: K21538
Entry
K21538                      KO                                     

Name
vTNFR2
Definition
Poxvirus tumor necrosis factor receptor II
Pathway
ko04061  Viral protein interaction with cytokine and cytokine receptor
Network
nt06150  Cytokine-cytokine receptor interaction (viruses)
  Element
N01188  VAV CrmB to CCR signaling
N01224  VAV CrmB to CCR signaling
N01246  VAV CrmB to CXCR signaling
N01248  VAV CrmB to CXCR signaling
N01255  VAV CrmB to CXCR signaling
N01276  VAV CrmB to TNFR signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04061 Viral protein interaction with cytokine and cytokine receptor
    K21538  vTNFR2; Poxvirus tumor necrosis factor receptor II
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K21538  vTNFR2; Poxvirus tumor necrosis factor receptor II
Viral proteins [BR:ko03200]
 dsDNA viruses
  Poxvirus
   K21538  vTNFR2; Poxvirus tumor necrosis factor receptor II
Genes
VG: 1485875(crmB) 1485876(crmB) 1486070(CrmC) 1486100(CrmD) 1486427(G4R) 1486845(SFV_s002L) 1487004(SFV_s002R) 1670230(MYXV_gp168) 24528036(ACG19_gp002) 24528241(ACG19_gp207) 29057580(BIZ96_gp002) 29057788(BIZ96_gp210) 29063949(BI079_gp002) 29064122(BI079_gp175) 29064152(BI079_gp205) 33867928(CKM52_gp002) 33867934(CKM52_gp008) 33868131(CKM52_gp205) 33868132(CKM52_gp206) 33868133(CKM52_gp001) 33868141(CKM51_gp008) 33868330(CKM51_gp197) 33868331(CKM51_gp001) 928919(J2L) 929019(J2R) 932138(m002L) 932503(CamMLVgp210) 932635(CamMLVgp002) 951577(EVM003) 951578(I1R)
Reference
PMID:8091665
  Authors
Hu FQ, Smith CA, Pickup DJ
  Title
Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor.
  Journal
Virology 204:343-56 (1994)
DOI:10.1006/viro.1994.1539
  Sequence
Reference
PMID:8806547
  Authors
Smith CA, Hu FQ, Smith TD, Richards CL, Smolak P, Goodwin RG, Pickup DJ
  Title
Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alpha.
  Journal
Virology 223:132-47 (1996)
DOI:10.1006/viro.1996.0462
  Sequence
[vg:1486070]
Reference
PMID:9520445
  Authors
Loparev VN, Parsons JM, Knight JC, Panus JF, Ray CA, Buller RM, Pickup DJ, Esposito JJ
  Title
A third distinct tumor necrosis factor receptor of orthopoxviruses.
  Journal
Proc Natl Acad Sci U S A 95:3786-91 (1998)
DOI:10.1073/pnas.95.7.3786
  Sequence
[vg:1486100]
Reference
PMID:8662837
  Authors
Schreiber M, Rajarathnam K, McFadden G
  Title
Myxoma virus T2 protein, a tumor necrosis factor (TNF) receptor homolog, is secreted as a monomer and dimer that each bind rabbit TNFalpha, but the dimer is  a more potent TNF inhibitor.
  Journal
J Biol Chem 271:13333-41 (1996)
DOI:10.1074/jbc.271.23.13333
  Sequence
Reference
  Authors
Saraiva M, Alcami A
  Title
CrmE, a novel soluble tumor necrosis factor receptor encoded by poxviruses.
  Journal
J Virol 75:226-33 (2001)
DOI:10.1128/JVI.75.1.226-233.2001
Reference
  Authors
Alejo A, Ruiz-Arguello MB, Ho Y, Smith VP, Saraiva M, Alcami A
  Title
A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.
  Journal
Proc Natl Acad Sci U S A 103:5995-6000 (2006)
DOI:10.1073/pnas.0510462103
  Sequence
[vg:1486427]
LinkDB

DBGET integrated database retrieval system