KEGG ORTHOLOGY: K21639

ORTHOLOGY: K21639

Entry

K21639                      KO

Symbol

E1.4.3.25

Name

L-arginine oxidase [EC:1.4.3.25]

Pathway

map00330

Arginine and proline metabolism

map01100

Metabolic pathways

Reaction

R11604

L-arginine:oxygen oxidoreductase (deaminating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K21639  E1.4.3.25; L-arginine oxidase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.3  With oxygen as acceptor
    1.4.3.25  L-arginine oxidase
     K21639  E1.4.3.25; L-arginine oxidase

Genes

LAVI:

INQ42_12295 INQ42_12305

CHEA:

PVE73_11645

APOL:

K9D25_10390

FLC:	KJS93_14500

SYC:

syc0596_c

SYU:	M744_11970

SYF:	Synpcc7942_0946

Reference

PMID:17542496

Authors

Gau AE, Heindl A, Nodop A, Kahmann U, Pistorius EK

Title

L-amino acid oxidases with specificity for basic L-amino acids in cyanobacteria.

Journal

Z Naturforsch C 62:273-84 (2007)
DOI:10.1515/znc-2007-3-419

Sequence

[syc:syc0596_c]

Reference

PMID:8547316

Authors

Bockholt R, Masepohl B, Kruft V, Wittmann-Liebold B, Pistorius EK

Title

Partial amino acid sequence of an L-amino acid oxidase from the cyanobacterium Synechococcus PCC6301, cloning and DNA sequence analysis of the aoxA gene.

Journal

Biochim Biophys Acta 1264:289-93 (1995)
DOI:10.1016/0167-4781(95)00154-9

Sequence

[syc:syc0596_c]

LinkDB

ENZYME: 1.4.3.25

Entry

EC 1.4.3.25                 Enzyme

Name

L-arginine oxidase

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor

Sysname

L-arginine:oxygen oxidoreductase (deaminating)

Reaction(IUBMB)

L-arginine + H2O + O2 = 5-guanidino-2-oxopentanoate + NH3 + H2O2 [RN:R11604]

Reaction(KEGG)

R11604

Substrate

L-arginine [CPD:C00062];
H2O [CPD:C00001];
O2 [CPD:C00007]

Product

5-guanidino-2-oxopentanoate [CPD:C03771];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]

Comment

Contains FAD. The enzyme from cyanobacteria can also act on other basic amino acids with lower activity. The enzyme from the bacterium Pseudomonas sp. TPU 7192 is highly specific.

History

EC 1.4.3.25 created 2017

Pathway

ec00330

Arginine and proline metabolism

ec01100

Metabolic pathways

Orthology

K21639

L-arginine oxidase

Genes

LAVI:

INQ42_12295 INQ42_12305

CHEA:

PVE73_11645

APOL:

K9D25_10390

FLC:	KJS93_14500

SYC:

syc0596_c

SYU:	M744_11970

SYF:	Synpcc7942_0946

Reference

1 [PMID:5570437]

Authors

Miller DL, Rodwell VW

Title

Metabolism of basic amino acids in Pseudomonas putida. Intermediates in L-arginine catabolism.

Journal

J Biol Chem 246:5053-8 (1971)

Reference

2 [PMID:6766743]

Authors

Pistorius EK, Voss H

Title

Some properties of a basic L-amino-acid oxidase from Anacystis nidulans.

Journal

Biochim Biophys Acta 611:227-40 (1980)
DOI:10.1016/0005-2744(80)90059-5

Reference

3 [PMID:17542496]

Authors

Gau AE, Heindl A, Nodop A, Kahmann U, Pistorius EK

Title

L-amino acid oxidases with specificity for basic L-amino acids in cyanobacteria.

Journal

Z Naturforsch C 62:273-84 (2007)
DOI:10.1515/znc-2007-3-419

Sequence

[syc:syc0596_c]

Reference

4 [PMID:26672462]

Authors

Matsui D, Terai A, Asano Y

Title

L-Arginine oxidase from Pseudomonas sp. TPU 7192: Characterization, gene cloning, heterologous expression, and application to L-arginine determination.

Journal

Enzyme Microb Technol 82:151-7 (2016)
DOI:10.1016/j.enzmictec.2015.10.002

Other DBs

ExplorEnz - The Enzyme Database:

1.4.3.25

IUBMB Enzyme Nomenclature:

1.4.3.25

ExPASy - ENZYME nomenclature database:

1.4.3.25

BRENDA, the Enzyme Database:

1.4.3.25

LinkDB

REACTION: R11604

Entry

R11604                      Reaction

Name

L-arginine:oxygen oxidoreductase (deaminating)

Definition

L-Arginine + H2O + Oxygen <=> 5-Guanidino-2-oxopentanoate + Ammonia + Hydrogen peroxide

Equation

C00062 + C00001 + C00007 <=> C03771 + C00014 + C00027

Reaction class

RC00006

C00062_C03771

Enzyme

1.4.3.25

Pathway

rn00330

Arginine and proline metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.3  With oxygen as acceptor
    1.4.3.25
     R11604  L-Arginine + H2O + Oxygen <=> 5-Guanidino-2-oxopentanoate + Ammonia + Hydrogen peroxide

Orthology

K21639

L-arginine oxidase [EC:1.4.3.25]

Other DBs

RHEA:

51407

LinkDB

DBGET integrated database retrieval system