KEGG ORTHOLOGY: K21796

ORTHOLOGY: K21796

Entry

K21796                      KO

Symbol

pebS

Name

Prochlorococcus phage phycoerythrobilin synthase [EC:1.3.7.6]

Pathway

map00860

Porphyrin metabolism

map01110

Biosynthesis of secondary metabolites

Reaction

R09491

(3Z)-phycoerythrobilin:ferredoxin oxidoreductase (from biliverdin IXalpha)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K21796  pebS; Prochlorococcus phage phycoerythrobilin synthase
09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K21796  pebS; Prochlorococcus phage phycoerythrobilin synthase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.6  phycoerythrobilin synthase
     K21796  pebS; Prochlorococcus phage phycoerythrobilin synthase
Viral proteins [BR:ko03200]
dsDNA viruses (phages)
  Other phage
   K21796  pebS; Prochlorococcus phage phycoerythrobilin synthase

Genes

VG:	10326923(PHM1_010) 10327881(PHM2_010) 10328732(SSSM7_163) 15010372(CPMG_00103) 15011722(CPXG_00107) 3294481(PSSM2_058) 65115485(KNU05_gp115)

Reference

PMID:15828858

Authors

Sullivan MB, Coleman ML, Weigele P, Rohwer F, Chisholm SW

Title

Three Prochlorococcus cyanophage genomes: signature features and ecological interpretations.

Journal

PLoS Biol 3:e144 (2005)
DOI:10.1371/journal.pbio.0030144

Sequence

[vg:3294481]

Reference

PMID:18356052

Authors

Dammeyer T, Bagby SC, Sullivan MB, Chisholm SW, Frankenberg-Dinkel N

Title

Efficient phage-mediated pigment biosynthesis in oceanic cyanobacteria.

Journal

Curr Biol 18:442-8 (2008)
DOI:10.1016/j.cub.2008.02.067

LinkDB

ENZYME: 1.3.7.6

Entry

EC 1.3.7.6                  Enzyme

Name

phycoerythrobilin synthase;
PebS

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor

Sysname

(3Z)-phycoerythrobilin:ferredoxin oxidoreductase (from biliverdin IXalpha)

Reaction(IUBMB)

(3Z)-phycoerythrobilin + 2 oxidized ferredoxin = biliverdin IXalpha + 2 reduced ferredoxin [RN:R09491]

Reaction(KEGG)

R09491

Substrate

(3Z)-phycoerythrobilin [CPD:C05912];
oxidized ferredoxin [CPD:C00139]

Product

biliverdin IXalpha;
reduced ferredoxin [CPD:C00138]

Comment

This enzyme, from a cyanophage infecting oceanic cyanobacteria of the Prochlorococcus genus, uses a four-electron reduction to carry out the reactions catalysed by EC 1.3.7.2 (15,16-dihydrobiliverdin:ferredoxin oxidoreductase) and EC 1.3.7.3 (phycoerythrobilin:ferredoxin oxidoreductase). 15,16-Dihydrobiliverdin is formed as a bound intermediate. Free 15,16-dihydrobiliverdin can also act as a substrate to form phycoerythrobilin.

History

EC 1.3.7.6 created 2008

Pathway

ec00860

Porphyrin metabolism

ec01110

Biosynthesis of secondary metabolites

Orthology

K21796

Prochlorococcus phage phycoerythrobilin synthase

Reference

1 [PMID:18356052]

Authors

Dammeyer T, Bagby SC, Sullivan MB, Chisholm SW, Frankenberg-Dinkel N

Title

Efficient phage-mediated pigment biosynthesis in oceanic cyanobacteria.

Journal

Curr Biol 18:442-8 (2008)
DOI:10.1016/j.cub.2008.02.067

Sequence

[vg:3294481]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.7.6

IUBMB Enzyme Nomenclature:

1.3.7.6

ExPASy - ENZYME nomenclature database:

1.3.7.6

BRENDA, the Enzyme Database:

1.3.7.6

LinkDB

REACTION: R09491

Entry

R09491                      Reaction

Name

(3Z)-phycoerythrobilin:ferredoxin oxidoreductase (from biliverdin IXalpha)

Definition

(3Z)-Phycoerythrobilin + 2 Oxidized ferredoxin <=> Biliverdin + 2 Reduced ferredoxin

Equation

C05912 + 2 C00139 <=> C00500 + 2 C00138

Comment

multi-step reaction (see R05818+R05819)

Reaction class

RC02553

C00500_C05912

Enzyme

1.3.7.6

Pathway

rn00860

Porphyrin metabolism

rn01110

Biosynthesis of secondary metabolites

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.6
     R09491  (3Z)-Phycoerythrobilin + 2 Oxidized ferredoxin <=> Biliverdin + 2 Reduced ferredoxin

Orthology

K21796

Prochlorococcus phage phycoerythrobilin synthase [EC:1.3.7.6]

Other DBs

RHEA:

25362

LinkDB

DBGET integrated database retrieval system