KEGG   ORTHOLOGY: K21796
Entry
K21796                      KO                                     
Symbol
pebS
Name
phycoerythrobilin synthase [EC:1.3.7.6]
Pathway
map00860  Porphyrin metabolism
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K21796  pebS; phycoerythrobilin synthase
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K21796  pebS; phycoerythrobilin synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.6  phycoerythrobilin synthase
     K21796  pebS; phycoerythrobilin synthase
Viral proteins [BR:ko03200]
 dsDNA viruses (phages)
  Prochlorococcus phage P-SSM2
   K21796  pebS; phycoerythrobilin synthase
Other DBs
RN: R09491
Genes
VG: 3294481(PSSM2_058)
Reference
  Authors
Sullivan MB, Coleman ML, Weigele P, Rohwer F, Chisholm SW
  Title
Three Prochlorococcus cyanophage genomes: signature features and ecological interpretations.
  Journal
PLoS Biol 3:e144 (2005)
DOI:10.1371/journal.pbio.0030144
  Sequence
[vg:3294481]
Reference
  Authors
Dammeyer T, Bagby SC, Sullivan MB, Chisholm SW, Frankenberg-Dinkel N
  Title
Efficient phage-mediated pigment biosynthesis in oceanic cyanobacteria.
  Journal
Curr Biol 18:442-8 (2008)
DOI:10.1016/j.cub.2008.02.067
LinkDB

KEGG   ENZYME: 1.3.7.6
Entry
EC 1.3.7.6                  Enzyme                                 
Name
phycoerythrobilin synthase;
PebS
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
Sysname
(3Z)-phycoerythrobilin:ferredoxin oxidoreductase (from biliverdin IXalpha)
Reaction(IUBMB)
(3Z)-phycoerythrobilin + 2 oxidized ferredoxin = biliverdin IXalpha + 2 reduced ferredoxin [RN:R09491]
Reaction(KEGG)
R09491
Substrate
(3Z)-phycoerythrobilin [CPD:C05912];
oxidized ferredoxin [CPD:C00139]
Product
biliverdin IXalpha;
reduced ferredoxin [CPD:C00138]
Comment
This enzyme, from a cyanophage infecting oceanic cyanobacteria of the Prochlorococcus genus, uses a four-electron reduction to carry out the reactions catalysed by EC 1.3.7.2 (15,16-dihydrobiliverdin:ferredoxin oxidoreductase) and EC 1.3.7.3 (phycoerythrobilin:ferredoxin oxidoreductase). 15,16-Dihydrobiliverdin is formed as a bound intermediate. Free 15,16-dihydrobiliverdin can also act as a substrate to form phycoerythrobilin.
History
EC 1.3.7.6 created 2008
Pathway
ec00860  Porphyrin metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K21796  phycoerythrobilin synthase
Reference
1  [PMID:18356052]
  Authors
Dammeyer T, Bagby SC, Sullivan MB, Chisholm SW, Frankenberg-Dinkel N
  Title
Efficient phage-mediated pigment biosynthesis in oceanic cyanobacteria.
  Journal
Curr Biol 18:442-8 (2008)
DOI:10.1016/j.cub.2008.02.067
  Sequence
[vg:3294481]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.6
IUBMB Enzyme Nomenclature: 1.3.7.6
ExPASy - ENZYME nomenclature database: 1.3.7.6
BRENDA, the Enzyme Database: 1.3.7.6
LinkDB

KEGG   REACTION: R09491
Entry
R09491                      Reaction                               
Name
(3Z)-phycoerythrobilin:ferredoxin oxidoreductase (from biliverdin IXalpha)
Definition
(3Z)-Phycoerythrobilin + 2 Oxidized ferredoxin <=> Biliverdin + 2 Reduced ferredoxin
Equation
C05912 + 2 C00139 <=> C00500 + 2 C00138
Comment
multi-step reaction (see R05818+R05819)
Reaction class
RC02553  C00500_C05912
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01110  Biosynthesis of secondary metabolites
Orthology
K21796  phycoerythrobilin synthase [EC:1.3.7.6]
Other DBs
RHEA: 25362
LinkDB

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