KEGG   ORTHOLOGY: K22472
Entry
K22472            Tight     KO                                     

Symbol
NS5B
Name
HCV RNA-dependent RNA polymerase [EC:2.7.7.48]
Pathway
map03230  Viral genome structure
map03240  Viral replication
map05160  Hepatitis C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22472  NS5B; HCV RNA-dependent RNA polymerase
   03240 Viral replication
    K22472  NS5B; HCV RNA-dependent RNA polymerase
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22472  NS5B; HCV RNA-dependent RNA polymerase
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22472  NS5B; HCV RNA-dependent RNA polymerase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.48  RNA-directed RNA polymerase
     K22472  NS5B; HCV RNA-dependent RNA polymerase
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus
   K22472  NS5B; HCV RNA-dependent RNA polymerase
Other DBs
GO: 0003968
Genes
VP: 951475-10(NS5B)
Reference
  Authors
Marascio N, Torti C, Liberto M, Foca A
  Title
Update on different aspects of HCV variability: focus on NS5B polymerase.
  Journal
BMC Infect Dis 14 Suppl 5:S1 (2014)
DOI:10.1186/1471-2334-14-S5-S1
  Sequence
Reference
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
LinkDB

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