KEGG   ORTHOLOGY: K22570
Entry
K22570                      KO                                     
Symbol
AF480
Name
5-dehydro-6-demethoxyfumagillol dioxygenase [EC:1.14.11.82]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00969  Fumagillin biosynthesis, farnesyl-PP => fumagillin
Reaction
R13122  5-dehydro-6-demethoxyfumagillol,2-oxoglutarate:oxygen oxidoreductase (6-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K22570  AF480; 5-dehydro-6-demethoxyfumagillol dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.82  5-dehydro-6-demethoxyfumagillol dioxygenase
     K22570  AF480; 5-dehydro-6-demethoxyfumagillol dioxygenase
Genes
MAJ: MAA_08347
PCHM: VFPPC_11134
AFM: AFUA_8G00480
NFI: NFIA_093990
Reference
PMID:24568283
  Authors
Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y
  Title
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
  Journal
J Am Chem Soc 136:4426-36 (2014)
DOI:10.1021/ja500881e
  Sequence
[afm:AFUA_8G00480]
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