KEGG ORTHOLOGY: K22583

ORTHOLOGY: K22583

Entry

K22583                      KO

Symbol

TIMP2

Name

metalloproteinase inhibitor 2

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K22583  TIMP2; metalloproteinase inhibitor 2
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I35: timp family
   K22583  TIMP2; metalloproteinase inhibitor 2

Other DBs

GO:

0008191

Genes

HSA:	7077(TIMP2)

PTR:	743167(TIMP2)

PPS:	100975666(TIMP2)

GGO:	101152140(TIMP2)

PON:	100453280(TIMP2)

PPYG:

129016909(TIMP2)

NLE:	100600221(TIMP2)

HMH:	116483030(TIMP2)

SSYN:

129462761(TIMP2)

MCC:	574357(TIMP2)

MCF:	102126333(TIMP2)

MTHB:

126939254

MNI:	105469384(TIMP2)

CSAB:

103243669(TIMP2)

CATY:

105577641(TIMP2)

PANU:

101010090(TIMP2)

TGE:	112608927(TIMP2)

MLEU:

105546383(TIMP2)

RRO:	104677028(TIMP2)

RBB:	108534173(TIMP2)

TFN:	117066779(TIMP2)

PTEH:

111542545(TIMP2)

CANG:

105521871(TIMP2)

CJC:	100401376(TIMP2)

SBQ:	101045173(TIMP2)

CIMI:

108301739(TIMP2)

ANAN:

105718060(TIMP2)

CSYR:

103249697(TIMP2)

MMUR:

105866724(TIMP2)

LCAT:

123621219(TIMP2)

PCOQ:

105824012(TIMP2)

OGA:	100959727(TIMP2)

MMU:	21858(Timp2)

MCAL:

110304304(Timp2)

MPAH:

110331588(Timp2)

RNO:	29543(Timp2)

MCOC:

116076812(Timp2)

ANU:	117709995(Timp2)

ASYL:

127693598(Timp2)

MUN:	110550233(Timp2)

CGE:	100772625(Timp2)

MAUA:

101826515(Timp2)

PROB:

127219816(Timp2)

PLEU:

114708946(Timp2)

MORG:

121436123(Timp2)

MFOT:

126500341

AAMP:

119811947(Timp2)

NGI:	103747293(Timp2)

HGL:	101707659(Timp2)

CPOC:

100135629(Timp2)

CCAN:

109682710(Timp2)

DORD:

106001210(Timp2)

DSP:	122096589(Timp2)

PLOP:

125366312(Timp2)

NCAR:

124979716

MMMA:

107157729(Timp2)

ITI:	101976189(Timp2)

OCU:

100008689

OPI:	101518166(TIMP2)

TUP:	102484570(TIMP2)

GVR:	103603112(TIMP2)

CFA:	403633(TIMP2)

CLUD:

112672878(TIMP2)

VVP:	112920669(TIMP2)

VLG:	121473309(TIMP2)

NPO:	129513349(TIMP2)

AML:	100476303(TIMP2)

UMR:	103665791(TIMP2)

UAH:	113244557(TIMP2)

UAR:	123802950(TIMP2)

ELK:

111160406

LLV:

125087177

MPUF:

101693910(TIMP2)

MNP:	132003356(TIMP2)

MLK:	131816554(TIMP2)

NVS:	122905928(TIMP2)

ORO:	101368123(TIMP2) 101370237

EJU:	114216191(TIMP2)

ZCA:	113939738(TIMP2)

MLX:	118024206(TIMP2)

NSU:	110572570(TIMP2)

LWW:	102743592(TIMP2)

FCA:	101083125(TIMP2)

PYU:	121017999(TIMP2)

PCOO:

112864541(TIMP2)

PBG:	122486154(TIMP2)

PVIV:

125152026(TIMP2)

LRUF:

124522552

LGF:	123604069(TIMP2)

AJU:

106981889

PTG:	102952846(TIMP2)

PPAD:

109276842(TIMP2)

PUC:

125927641

HHV:	120228217(TIMP2)

BTA:	282093(TIMP2)

BOM:	102273590(TIMP2)

BIU:	109573343(TIMP2)

BBUB:

102400367(TIMP2)

BBIS:

105000569(TIMP2)

CHX:	102178107(TIMP2)

OAS:	100217406(TIMP2)

BTAX:

128064707(TIMP2)

CSUM:

138082845(TIMP2)

ODA:	120866824(TIMP2)

CCAD:

122437828(TIMP2)

MREE:

136148901(TIMP2)

OVR:	110139047(TIMP2)

MBEZ:

129544654(TIMP2)

SSC:	396988(TIMP2)

CFR:	102510577(TIMP2)

CBAI:

105065591(TIMP2)

CDK:	105105802(TIMP2)

VPC:	102544723(TIMP2)

BACU:

103015890

BMUS:

118886331(TIMP2)

LVE:

103070305

OOR:	101285873(TIMP2)

LALB:

132510763(TIMP2)

DLE:	111182748(TIMP2)

PCAD:

102990167(TIMP2)

PSIU:

116745312(TIMP2)

NASI:

112410303(TIMP2)

ECB:	100034134(TIMP2)

EPZ:	103551447(TIMP2)

EAI:	106845378(TIMP2)

MYB:	102249808(TIMP2)

MYD:	102764117(TIMP2)

MMYO:

118671299(TIMP2)

MLF:	102435320(TIMP2)

MDT:	132219168(TIMP2)

MYUM:

138994868(TIMP2)

PKL:	118704554(TIMP2)

EFUS:

103298378(TIMP2)

MNA:	107532016(TIMP2)

DRO:	112298694(TIMP2)

SHON:

118999626(TIMP2)

AJM:	119058603(TIMP2)

PDIC:

114502859(TIMP2)

PHAS:

123816754(TIMP2)

MMF:	118633869(TIMP2)

PPAM:

129086410(TIMP2)

RFQ:	117013028(TIMP2)

PALE:

102887077(TIMP2)

PGIG:

120600336(TIMP2)

PVP:	105293404(TIMP2)

RAY:	107510069(TIMP2)

MJV:	108403583(TIMP2)

TOD:	119230803(TIMP2)

SARA:

101555767(TIMP2)

SFUM:

130024951(TIMP2)

SETR:

126013681(TIMP2)

LAV:	100662033(TIMP2)

ETF:	101652538(TIMP2)

DNM:	101446238(TIMP2)

MDO:	100030996(TIMP2)

GAS:	123243806(TIMP2)

SHR:	100916562(TIMP2)

AFZ:

127560687

PCW:	110193891(TIMP2)

TVP:	118848044(TIMP2)

PBRV:

138152369(TIMP2)

OAA:	100085420(TIMP2)

TACU:

119922009(TIMP2)

GGA:	374178(TIMP2)

PCOC:

116232539(TIMP2)

MGP:	100548512(TIMP2)

CJO:	107322230(TIMP2)

TPAI:

128082917(TIMP2)

LMUT:

125702268(TIMP2)

NMEL:

110407498(TIMP2)

ACYG:

125180389(TIMP2)

CATA:

118259299(TIMP2)

AFUL:

116496590(TIMP2)

TGU:	100223365(TIMP2)

LSR:	110472447(TIMP2)

SCAN:

103819928(TIMP2)

PMOA:

120505518(TIMP2)

OTC:	121338237(TIMP2)

PRUF:

121363446(TIMP2)

ATRC:

139602008(TIMP2)

GFR:	102035308(TIMP2)

FAB:	101811279(TIMP2)

OMA:	130260358(TIMP2)

PHI:	102108107(TIMP2)

PMAJ:

107212246(TIMP2)

CCAE:

111945052(TIMP2)

CCW:	104698208(TIMP2)

CBRC:

103613581(TIMP2)

ACOE:

138120113(TIMP2)

ETL:	114060376(TIMP2)

ZLE:	135455586(TIMP2)

ACHL:

103797523(TIMP2)

SVG:	106859951(TIMP2)

MMEA:

130582016(TIMP2)

HRT:	120761055(TIMP2)

SATI:

136369398(TIMP2)

CCIC:

134051984(TIMP2)

FPG:	101917952(TIMP2)

FCH:	102051750(TIMP2)

CCRI:

104169562(TIMP2)

NNT:	104404914(TIMP2)

SHAB:

115616568(TIMP2)

TALA:

116963118(TIMP2)

ACHC:

115341004(TIMP2)

HLE:	104832127(TIMP2)

AGEN:

126043462

HHAR:

128150868(TIMP2)

GCL:

127024159

CSTI:

104559372(TIMP2)

MNB:	103780149(TIMP2)

DPUB:

104297968(TIMP2)

PPUS:

135179236(TIMP2)

EGZ:

104132681

NNI:	104015090(TIMP2)

PADL:

103917449(TIMP2)

AFOR:

103896898(TIMP2)

FGA:

104080648

CBOY:

140660275(TIMP2)

CLV:	102092005(TIMP2)

PLET:

104624575(TIMP2)

CUCA:

104059457(TIMP2)

CPEA:

104398548(TIMP2)

CVF:	104283150(TIMP2)

RTD:	128918037(TIMP2)

CRID:

134523192(TIMP2)

AROW:

112974779(TIMP2)

NPD:	112945345(TIMP2)

DNE:	112991611(TIMP2)

ASN:	102382775(TIMP2)

AMJ:	102568098(TIMP2)

CPOO:

109315185(TIMP2)

GGN:	109295817(TIMP2)

PSS:	102445783(TIMP2)

CMY:	102929916(TIMP2)

CCAY:

125621184(TIMP2)

DCC:	119842861(TIMP2)

CPIC:

101951916(TIMP2)

TST:	117887307(TIMP2)

CABI:

116835888(TIMP2)

MRV:	120383357(TIMP2)

ACS:	100566015(timp2)

ASAO:

132768456(TIMP2)

PVT:	110090314(TIMP2)

SUND:

121922799(TIMP2)

PBI:	103067392(TIMP2)

PMUR:

107292204(TIMP2)

CTIG:

120308798(TIMP2)

TSR:	106543735(TIMP2) 106556421

PGUT:

117663016(TIMP2)

APRI:

131193569(TIMP2)

PTEX:

113437047(TIMP2)

NSS:	113411972(TIMP2)

VKO:	123018094(TIMP2)

PMUA:

114589145(TIMP2)

PRAF:

128407341(TIMP2)

ZVI:	118079717(TIMP2)

HCG:	128343493(TIMP2)

GJA:	107115312(TIMP2)

STOW:

125429085(TIMP2)

EMC:	129328198(TIMP2)

XLA:	398383(timp2.S) 447572(timp2.L)

XTR:	548477(timp2)

NPR:	108796402(TIMP2)

RTEM:

120918885(TIMP2)

BBUF:

121004028(TIMP2)

BGAR:

122940205(TIMP2) 122943104 122943127 122943623

PWL:	138245780(TIMP2)

MUO:	115473563(TIMP2)

GSH:	117368714(TIMP2)

DRE:	359835(timp2a) 406650(timp2b)

SRX:	107717489 107722175 107732160 107755484

SANH:

107671258 107675603 107684079 107690949

SGH:	107552122 107565802 107572670 107581596

CCAR:

109073376(timp2b) 109084672(timp2a) 109084694

CAUA:

113047574 113053130 113055949 113070568 113094480

CGIB:

127944517 127953159 127969075 127975316 128025423

PTET:

122335416(timp2b) 122355490(timp2a)

LROH:

127162342(timp2b) 127173954(timp2a)

OMC:	131533761(timp2b) 131550935(timp2a)

PPRM:

120474663(timp2a) 120476213(timp2b)

RKG:	130095257(timp2b) 130105424(timp2a)

MAMB:

125243536(timp2b) 125255038(timp2a)

CIDE:

127508287 127524110

CERY:

137007448(timp2a) 137017978(timp2b)

MASI:

127423058 127427453 127450411 127452177

TROS:

130561473(timp2b) 130569312(timp2a)

TDW:	130439436(timp2a)

MANU:

129420868(timp2a) 129427002(timp2b)

PDAB:

135732038 135744479(timp2a) 135761050

IPU:	108274067(timp2a) 108277022(timp2b)

IFU:	128616834(timp2a) 128625608(timp2b)

PHYP:

113527474(timp2) 113528303

SMEO:

124388843(timp2a) 124397092

TFD:	113639010(timp2a) 113639582(timp2b)

TVC:	132837713(timp2a) 132860871(timp2b)

CGAR:

128541171(timp2a) 128544546(timp2b)

NGRA:

132868524 132898418(timp2a)

TRN:	134321321(timp2a) 134335909(timp2b)

AMEX:

103024286(timp2a) 103028836(timp2b)

CMAO:

118809378(timp2a) 118820960(timp2b)

EEE:	113571401 113577659

CHAR:

105908592(timp2a) 122132079

SPIL:

134070106(timp2a) 134076465

TRU:	654284(timp2) 654285(timp-2b)

TFS:	130515596 130533165(timp2a)

TNG:	GSTEN00002383G001 GSTEN00007353G001 GSTEN00018576G001

LCO:	104925068 104933895(timp2)

NCC:	104944612 104953404

TBEN:

117473656(timp2a) 117493050 117493060

CGOB:

115012585 115024551(timp2)

PGEO:

117451005 117451519 117464806(timp2a)

GACU:

117544405(timp2a) 117548667 117548841

EMAC:

134870652(timp2a) 134877849(timp2b)

ELY:	117247605 117267840(timp2b)

EFO:	125879376(timp2b) 125881158(timp2a)

PLEP:

121956489(timp2b) 121958411(timp2a)

SLUC:

116059570(timp2b) 116061019(timp2a)

ECRA:

117936465(timp2a) 117958655

ESP:	116671760(timp2) 116703211 116707453

PFLV:

114548437 114570106

GAT:	120819532(timp2a) 120827967(timp2b)

PPUG:

119213225(timp2a) 119220974(timp2b)

AFB:	129090937(timp2a) 129098243(timp2b)

CLUM:

117734863(timp2b) 117748643(timp2a)

PSWI:

130189322(timp2b) 130203373(timp2a)

CANA:

137786655(timp2b) 137789512(timp2a)

CVE:

137878359

MSAM:

119890239(timp2b) 119916598(timp2a)

SCHU:

122867271(timp2a) 122868893(timp2b)

CUD:	121503321(timp2b) 121528332(timp2a)

SPUL:

138593362(timp2a) 138602763(timp2b)

LMIX:

132955773(timp2a) 132995614(timp2b)

ALAT:

119009852(timp2a) 119014686(timp2b)

ASTR:

137588433(timp2a) 137610012

MZE:	101467613 101480790(timp2)

ONL:	100702284 100703694(timp2)

OAU:	116322704(timp2a) 116325202(timp2b)

OLA:	100529160(timp2) 100529200(timp-2b)

OML:	112146029(timp2b) 112154347(timp2a)

CSAI:

133419611(timp2a) 133421924(timp2b)

XMA:	102223119 102231470(timp2)

XCO:	114151896(timp2) 114159820

XHE:	116726877(timp2) 116735338

PRET:

103468846 103481516

PFOR:

103140958 103145157(timp2)

PLAI:

106936699 106964102

PMEI:

106920080 106927469(timp2)

GAF:	122822011 122823394(timp2a)

PPRL:

129363865(timp2b) 129368167(timp2a)

CVG:	107083192 107089241(timp2)

CTUL:

119778276(timp2b) 119793608(timp2a)

GMU:	124862176 124863864 124874875(timp2a)

NFU:	107387729(timp2)

KMR:	108241333(timp2b) 108248373(timp2a)

ALIM:

106516653(timp2) 106518661 106518665 106518666 106518667 106528551 106528552 106528553 106528554 106531617 106531618

NWH:	119420998 119420999 119421171 119421676 119421677 119421679 119421680

AOCE:

111564615(timp2b)

EJA:	138197971(timp2b) 138204780(timp2a)

BFRE:

138623378(timp2b) 138636351(timp2a)

MCEP:

125022154(timp2a)

CSEM:

103381774 103392814 103392824

POV:	109627087 109633947

SSEN:

122758792(timp2a) 122760622 122760623 122760624 122760629

SSOE:

131448196(timp2a) 131475578 131476059 131476060 131476062

HHIP:

117753309(timp2a) 117765690(timp2b)

HSP:	118100537(timp2a) 118123557(timp2b)

PPLT:

128426690(timp2a) 128458853(timp2b)

SMAU:

118286983(timp2a) 118289004(timp2b)

LCF:	108876197(timp2a) 108902662(timp2b)

SDU:	111219962(timp2) 111227194

SLAL:

111657764 111673526(timp2)

XGL:	120784529(timp2b) 120794251(timp2a)

HCQ:	109516494 109519301 109519374 109519375 109519376 109519377 109519379 109519380 109521563

SSCV:

125983905 125983908 125983910 125983911 125983915 125983916 125991537(timp2a)

SBIA:

133495703(timp2a) 133513971 133513973 133513974 133514380 133514866 133514994 133514995 133514996

PEE:	133414733 133415129 133415130 133415131 133415134 133415135 133415146 133417690(timp2a)

PTAO:

133465474 133465475 133465476 133465477 133465478 133465479 133466423 133466441 133466442 133466443 133466461 133466498 133466499 133469002(timp2a)

BPEC:

110167617 110170866

ENY:	140358435(timp2b) 140369064(timp2a)

MALB:

109963039(timp2) 109972220

BSPL:

114845824(timp2a) 114860947(timp2b)

SJO:	128379088(timp2b) 128381361(timp2a)

SSCO:

133999364(timp2b) 134003327(timp2a)

GMH:	115530826 115556743

SASA:

100196250(timp2) 106589839(TIMP2) 106591286 106592142 106593126 106594492 106594905 106595712 106597430 106597469 106597581 106597616 106598564 106606418 106606431 106606432 106612362

STRU:

115153475 115171819 115171822 115189501 115189502 115189503 115201655 115205516 115207239 115207243 115207252 115207262 115207285 115207295 115207305

OTW:	112229885 112238057 112238060 112238062 112257413(timp2a) 112265094 121844921 121844922 121845009

OMY:	100136244 110487071 110487072 110487073 110487074 110487076 110499421 110502745(timp2a) 110513845 110538848 118936370 118936479 118937778 118937779 118938344 118938345 118938346

OGO:	124019994 124024264 124024268 124024421 124024422 124024900 124024901 124024902 124026260 124038441(timp2a) 124040389

ONE:	115113010 115116401 115116458 115121105 115123383 115123987

OKI:	109876306 109876307 109876472 109877308 109877554 109889434 109899901 116352804 116359895 116359896 116359897 116365218

OKE:	118372799 118380699 118380700 118398068(timp2a) 118402728 127921201 127930158 127930159 127930160 127930161

OMM:	135512107(timp2a) 135523421 135537478 135553771 135553772 135553774 135553775 135553786 135553787 135553869 135553871 135554731 135554733 135554734 135554740 135554785 135554786

OCLA:

139365167 139365169 139365170 139376955 139381980 139399731 139399732 139402162 139424078 139424079 139424080

SALP:

111968154 111978288 112079800 112080112

CCLU:

121547709 121551202 121551207 121551208 121551209 121551210 121568706 121568708 121575447 121584706 123491180

ELS:	105013051 105026286(timp2)

OEP:	134009177 134031697(timp2a)

SFM:	108922557 108924828(timp2)

PKI:	111839614 111848422(timp2)

AANG:

118216473 118216647

AROT:

135243373 135249437

CCOG:

133114817 133122694

LOC:	102689477(timp2)

PSPA:

121295504 121296256

ARUT:

117423580 117424762

PSEX:

120518049

LCM:	102345899(TIMP2) 102361064

CMK:	103175548(timp2a)

RTP:	109931463(timp2a)

CPLA:

122562213(timp2a)

HOC:	132828001(timp2a)

LERI:

129708243(timp2a)

BBEL:

109467109

SPU:	100889413 115919543 762609

LPIC:

129256905

AJJ:

139961187

APLC:

110983670

ARUN:

117305747 117306255 117307165

AAMU:

AFIL:

BCOO:

MDL:

PCHN:

HAME:

PTRU:

MNZ:

MRJ:	136856165(Timp)

DFR:

124496963

LPOL:

106464718

NAI:	NECAME_07191 NECAME_13168

PCAN:

112559837 112560685

HRF:

124134931

HCRA:

139445357

CRG:	105319608 105333665 105342751 105342766 117686271 117686279

CANU:

128158863 128158868 128158869 128160250 128160318 128160388 128160558 128161557 128164150

CVN:	111102533 111106494

OED:	125654610 125654886 125655904 125656209 125672094 130050974

MYI:	110442122 110442135 110448829 110461210 110461213 110461263 110465153

PMAX:

117331068 117331851

AIRR:

138305151 138335921 138336439

MMER:

123529644 123537209 123539134 123556301

RPHI:

132714279 132714281 132723175 132726135

LLON:

135491151

PDAM:

113675075 113675076

CCP:	CHC_T00003290001

RAD:	CO657_11980

» show all

Reference

PMID:2380196

Authors

Stetler-Stevenson WG, Brown PD, Onisto M, Levy AT, Liotta LA

Title

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

Journal

J Biol Chem 265:13933-8 (1990)

Sequence

[hsa:7077]

LinkDB

DBGET integrated database retrieval system