KEGG   ORTHOLOGY: K22622
Entry
K22622                      KO                                     
Symbol
soxD
Name
S-disulfanyl-L-cysteine oxidoreductase SoxD [EC:1.8.2.6]
Pathway
map00920  Sulfur metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Module
M00595  Thiosulfate oxidation by SOX complex, thiosulfate => sulfate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K22622  soxD; S-disulfanyl-L-cysteine oxidoreductase SoxD
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.2  With a cytochrome as acceptor
    1.8.2.6  S-disulfanyl-L-cysteine oxidoreductase
     K22622  soxD; S-disulfanyl-L-cysteine oxidoreductase SoxD
Other DBs
RN: R10151
COG: COG3258
Genes
PBC: CD58_18895
PQI: KH389_17590
PASG: KSS96_11330
PORY: EJA05_17215
MSQ: BKP64_06065
MARA: D0851_07305
KIM: G3T16_11190
AFUS: EYZ66_09765
METU: GNH96_09145
MAH: MEALZ_1454
MMAI: sS8_0589
TCX: Tcr_0157
HMAR: HVMH_0149
RFO: REIFOR_02317(soxD)
REH: H16_A3571(soxD) H16_B2221(h16_B2221)
CGD: CR3_2733
BTD: BTI_5283
BCN: Bcen_1239
BCJ: BCAS0417
BCEO: I35_7459
BCT: GEM_4759
BCED: DM42_6978
BSEM: WJ12_18430
BGO: BM43_5313
BUL: BW21_4932
BPH: Bphy_7231
BFN: OI25_51
PNU: Pnuc_0802
PPNO: DA70_17185
PPNM: LV28_13565
PPUL: RO07_07505
PSPU: NA29_03385
PAPI: SG18_07945
POL: Bpro_2630
ACRA: BSY15_3141
CTES: O987_17365
RTA: Rta_13790
HYB: Q5W_03640
HPSE: HPF_06270(cyt)
MMS: mma_0447
LCH: Lcho_3783
TIN: Tint_2299
THI: THI_2672
DAR: Daro_3133
BPRC: D521_0984
SUA: Saut_2097
SULC: CVO_09760
SHAL: SHALO_2481
ABU: Abu_0566(soxD)
ATP: ATR_1125(soxD)
ACIB: ACBT_0934(soxD)
ACRE: ACRYA_1212(soxD)
ALAN: ALANTH_0581(soxD)
APOC: APORC_1664(soxD)
AFC: AFAEC_0759(soxD)
ATHR: ATH_1571(soxD)
AELL: AELL_0707(soxD)
AAQI: AAQM_0613(soxD)
ASUI: ASUIS_0663(soxD)
ACLO: ACLO_0690(soxD)
AVP: AVENP_0803(soxD)
ADZ: ADFLV_0701(soxD)
ALK: ALEK_2891(soxD)
AHS: AHALO_0636(soxD)
AMAR: AMRN_0696(soxD)
ACAA: ACAN_0716(soxD)
AMOL: AMOL_0620(soxD)
APAI: APAC_0587(soxD)
HBV: ABIV_1384(soxD)
HEBR: AEBR_1634(soxD)
AANA: AANAER_1633(soxD)
PACO: AACT_0810(soxD)
ARC: ABLL_0687
SUN: SUN_0050
ADE: Adeh_2285
AGC: BSY240_3519(soxD)
RHT: NT26_2611(soxD)
BJA: bll6120(bll6120) blr3517(soxD)
BRA: BRADO3185
BRS: S23_18010
AOL: S58_14060 S58_44010(soxD)
RPA: RPA4463
RPB: RPB_4367
RPD: RPD_4251
RPE: RPE_3071
RPT: Rpal_4956
NWI: Nwi_2987
NHA: Nham_1094
OCA: OCAR_5181
BOS: BSY19_753
XAU: Xaut_1517
AZC: AZC_3166
SNO: Snov_0967
MEX: Mext_3340
MCH: Mchl_3665
MPO: Mpop_4162
MET: M446_0147
MNO: Mnod_8678
META: Y590_17320
HDN: Hden_1145
BLAG: BLTE_06850(soxD)
HDI: HDIA_3887
PSF: PSE_1361(soxD)
SIL: SPO0999(soxD)
RDE: RD1_1517(soxD)
RLI: RLO149_c031820(soxD4)
PGA: PGA1_c12480(soxD2)
PGL: PGA2_c12460(soxD2)
PGD: Gal_02157
PHP: PhaeoP97_01244(soxD2)
PPIC: PhaeoP14_01167(soxD2)
OTM: OSB_13250
MALG: MALG_03480
MALU: KU6B_10820
PDE: Pden_4156
PTP: RCA23_c17350(soxD2)
RSU: NHU_02674(soxD)
RHC: RGUI_3431
PAMO: BAR1_03185
ACR: Acry_3042
AMV: ACMV_33880(soxD)
HTL: HPTL_0810(soxD)
TTH: TT_C1045
TTJ: TTHA1410(TTHA1410)
TAQ: TO73_0522
MRB: Mrub_2868
GBA: J421_1808
CPI: Cpin_0341
CHU: CHU_0560(soxD)
SLI: Slin_2734
DFE: Dfer_1616
FAE: FAES_1991
NJA: NSJP_3283
 » show all
Reference
  Authors
Bardischewsky F, Quentmeier A, Rother D, Hellwig P, Kostka S, Friedrich CG
  Title
Sulfur dehydrogenase of Paracoccus pantotrophus: the heme-2 domain of the molybdoprotein cytochrome c complex is dispensable for catalytic activity.
  Journal
Biochemistry 44:7024-34 (2005)
DOI:10.1021/bi047334b
LinkDB

KEGG   ENZYME: 1.8.2.6
Entry
EC 1.8.2.6                  Enzyme                                 
Name
S-disulfanyl-L-cysteine oxidoreductase;
SoxCD;
sulfur dehydrogenase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a cytochrome as acceptor
Sysname
[SoxY protein]-S-disulfanyl-L-cysteine:cytochrome-c oxidoreductase
Reaction(IUBMB)
[SoxY protein]-S-disulfanyl-L-cysteine + 6 ferricytochrome c + 3 H2O = [SoxY protein]-S-sulfosulfanyl-L-cysteine + 6 ferrocytochrome c + 6 H+ [RN:R11971]
Reaction(KEGG)
R11971
Substrate
[SoxY protein]-S-disulfanyl-L-cysteine [CPD:C21814];
ferricytochrome c [CPD:C00125];
H2O [CPD:C00001]
Product
[SoxY protein]-S-sulfosulfanyl-L-cysteine [CPD:C21815];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. The enzyme from the bacterium Paracoccus pantotrophus contains a molybdoprotein component and a diheme c-type cytochrome component. The enzyme successively oxidizes the outer sulfur atom in [SoxY protein]-S-disulfanyl-L-cysteine, using three water molecules and forming [SoxY protein]-S-sulfosulfanyl-L-cysteine. During the process, six electrons are transferred to the electron chain via cytochrome c.
History
EC 1.8.2.6 created 2018
Pathway
ec00920  Sulfur metabolism
Orthology
K22622  S-disulfanyl-L-cysteine oxidoreductase SoxD
Genes
PBCCD58_18895
PQIKH389_17590
PASGKSS96_11330
PORYEJA05_17215
MSQBKP64_06065
MARAD0851_07305
KIMG3T16_11190
AFUSEYZ66_09765
METUGNH96_09145
MAHMEALZ_1454
MBUREQU24_13355
MMAIsS8_0589
MMOBF6R98_06955
MISZMishRS11D_07190
TCXTcr_0157
HTREPV75_01070
HMARHVMH_0149
TCYThicy_0051
TAOTHIAE_00355
THIOAYJ59_12540
THIGFE785_00700
TXAHQN79_00775
TSETHMIRHAS_01550
TZOTHMIRHAT_20850
HNAHneap_0586
HAZA9404_12905
WOCBA177_08575
GAIIMCC3135_00520 IMCC3135_19370(tsdA)
GHLGM160_08830
NCUF0U83_06350
NJPNEJAP_2238
AJPAMJAP_1128
RFOREIFOR_02317(soxD)
LLPGH975_09730
VFFVITFI_CDS0984
RPJN234_19955
REHH16_A3571(soxD) H16_B2221(h16_B2221)
CNCCNE_1c35210(soxD) CNE_2c21990
CUHBJN34_19070 BJN34_22365
REUReut_A3257
CTIRALTA_A3024 RALTA_B1994
CBWRR42_m4003 RR42_s2458
CGDCR3_2733
CCUPBKK81_00885
CUPBKK80_00215
CUUBKK79_11935
COXE0W60_27005
BTDBTI_5283
BCNBcen_1239
BCHBcen2424_6593
BCMBcenmc03_6197
BCJBCAS0417
BCEOI35_7459
BCTGEM_4759
BCEDDM42_6978
BCEPAPZ15_29900
BSEMWJ12_18430
BSTLBBJ41_36645
BGFBC1003_5157
BGDbgla_2g16270
BGOBM43_5313
BUEBRPE67_FCDS01670
BULBW21_4932
BUQAC233_28255
BGPBGL_2c15900
BUDAQ610_28515
BURKDM992_38415
BXEBxe_A2167 Bxe_C0152
BXBDR64_4321 DR64_8277
BPHBphy_7231
BGEBC1002_6610
BPXBUPH_00062
BFNOI25_51
BCAIK788_0001912
PSPWBJG93_30545
PARABTO02_28375
PARBCJU94_14810
PHSC2L64_44070
PTERC2L65_41435
PGPCUJ91_27960
PCJCUJ87_30480
PTSCUJ90_09215
PMEGFNZ07_11260
PGISI6I06_26405
PEWKZJ38_32040
PDIOPDMSB3_2164
PNUPnuc_0802
PDQCL55_00010960
PPKU875_24460
PPNODA70_17185
PPNMLV28_13565
PRBX636_09690
PPULRO07_07505
PSPUNA29_03385
PAPISG18_07945
PVEUC34_23600
POXMB84_03615
PFGAB870_10515
PNRAT302_07125
PANDDRB87_22055
PFIBPI93_023635
BUOBRPE64_DCDS04780
BFZBAU07_03110 BAU07_15745
AXYAXYL_05429
ADYHLG70_08830
PUDG9Q38_09575
AKATKWG_00580 TKWG_08965 TKWG_22135
AMIMMIM_c01590 MIM_c36010
PARKLSG25_11115
RACRA876_14695
POLBpro_2630
POSDT070_18165
POOF7R28_12420
ACRABSY15_3141
AMONH9L24_00230
VBOCKY39_30940
CTTCtCNB1_2872
CTESO987_17365
COFFOZ74_01825
CODOLAD35_04880
RTARta_13790
LIML103DPR2_01202
LIHL63ED372_00546
HYRBSY239_832
HYBQ5W_03640
HYLLPB072_18275
HYCE5678_10645
HPSEHPF_06270(cyt)
HYNF9K07_22675 F9K07_22780
HTNKI616_20180
DIHG7047_06250
DAERH9K75_21770
DRGH9K76_15025
SIMPC6571_14195
MELAC6568_08800
MJELVC68_00160
KIAG8A07_27235
MPTMpe_A0912 Mpe_A2087 Mpe_A2437
METPC1M51_13760 C1M51_15805 C1M51_17255
HARHEAR1026 HEAR1189
MMSmma_0447
HEEhmeg3_11225
LCHLcho_3783
TINTint_2299
THITHI_2672
SNNEWH46_01820
XYKGT347_19105
TTWLCC91_08245
IDCLRM40_06595
METRBSY238_1420 BSY238_1521
SPLBSFPGR_26240
URUDSM104443_02057
UPLDSM104440_01891
OTROTERR_06910
ATWC0099_11280
DARDaro_3133
DEYHYN24_04360
QAUKI612_14935
FLEKI610_07360
ACOMCEW83_09825
AZRCJ010_06860
THUAC731_000115
AZQG3580_13955
BPRCD521_0984
BEBAEM42_07750
BEBABWI17_16405
TDNSuden_2059
SUASaut_2097
SULNFJR47_09450
SULGFJR48_00375
SULCCVO_09760
SPALFM071_10015
SSEIFJR45_11885
SBALHUE88_13505
SMASHUE87_12335
SHALSHALO_2481
ABUAbu_0566(soxD)
ASKEI285_02180
ATPATR_1125(soxD)
ACIBACBT_0934(soxD)
ACREACRYA_1212(soxD)
ALANALANTH_0581(soxD)
APOCAPORC_1664(soxD)
AFCAFAEC_0759(soxD)
ATHRATH_1571(soxD)
ANTArnit_1817
AELLAELL_0707(soxD)
AAQIAAQM_0613(soxD)
ASUIASUIS_0663(soxD)
ACLOACLO_0690(soxD)
AVPAVENP_0803(soxD)
ADZADFLV_0701(soxD)
ALKALEK_2891(soxD)
ALPLPB137_11535
AHSAHALO_0636(soxD)
AMARAMRN_0696(soxD)
ACAAACAN_0716(soxD)
AMOLAMOL_0620(soxD)
APAIAPAC_0587(soxD)
HBVABIV_1384(soxD)
HEBRAEBR_1634(soxD)
AANAAANAER_1633(soxD)
PACOAACT_0810(soxD)
ARCABLL_0687
NSANitsa_0362
SUNSUN_0050
SLHYH65_10425
SINUIMZ28_10585
ADEAdeh_2285
ACPA2cp1_1666
ANKAnaeK_1590
PAUUE8A73_004925
MESOBSQ44_10565
HOEIMCC20628_01341
NIYFQ775_21015
ORMHTY61_03415
AGCBSY240_3519(soxD)
RHTNT26_2611(soxD)
RFVRFYW14_02657
BJAbll6120(bll6120) blr3517(soxD)
BJUBJ6T_24690 BJ6T_35830
BJPRN69_12040 RN69_17375
BRABRADO3185
BBTBBta_1895 BBta_3677 BBta_4887
BRSS23_18010
AOLS58_14060 S58_44010(soxD)
BRADBF49_5146 BF49_5508
BICLMTR13_09060 LMTR13_36650
BROBRAD285_2963
BRKCWS35_28105
BOTCIT37_36630
BRQCIT40_11190 CIT40_24480
BGQX265_02715 X265_11885
BGZXH91_02905 XH91_07660 XH91_10890 XH91_21955
BSYMCIT39_10300 CIT39_23475
BBETF8237_24095
BARHWN72_25800 WN72_34150 WN72_37315 WN72_42950
BELBE61_63650
BSEPHAP48_0034365
BQBJ4P68_0034850 J4P68_0035630
RPARPA4463
RPBRPB_4367
RPDRPD_4251
RPERPE_3071
RPTRpal_4956
RPXRpdx1_3141
NWINwi_2987
NHANham_1094
OCAOCAR_5181
OCGOCA5_c27870
OCOOCA4_c27860
VGOGJW-30_1_01698
TRBHB776_12285 HB776_12580
BOSBSY19_753
BOIBLM15_25505
XAUXaut_1517
XDIEZH22_00500
AZCAZC_3166
SNOSnov_0967
STARG3545_26215
ANCGBB76_12410
MEAMex_1p2568 Mex_1p3559
MDIMETDI0753 METDI0787 METDI4135
MEXMext_3340
MCHMchl_3665
MPOMpop_4162
MZAB2G69_24255
MRDMrad2831_5874
METM446_0147
MNOMnod_8678
METAY590_17320
METDC0214_07165 C0214_09210
METSDK389_22800
METIDK427_08860
MMESMMSR116_16050
MOGMMB17_03075 MMB17_08220
BBARRHAL1_00423
HDNHden_1145
HDTHYPDE_31938
HMCHYPMC_2349
FILBN1229_v1_3559(SoxD) BN1229_v1_3696
FIYBN1229_v1_2365(soxD) BN1229_v1_3690
RHZRHPLAN_07040 RHPLAN_21620 RHPLAN_44720 RHPLAN_62710
BLAGBLTE_06850(soxD)
MTWCQW49_22130
CMETK6K41_10020 K6K41_12410
HDIHDIA_3887
AUBLXB15_05835
BRND1F64_10970
PSINCAK95_23440
PSFPSE_1361(soxD)
LAPACP90_06490
LABRCHH27_14125
LABPFJ695_08770
LABTFIU93_12130
LAGGB0E33_18040
SIWGH266_01560
PHRC6569_08460
PSTGE8M01_30420
SILSPO0999(soxD)
RUAD1823_09080
RUTFIU92_04325
RDERD1_1517(soxD)
RLIRLO149_c031820(soxD4)
RPONG3256_14745
DSHDshi_2801 Dshi_3211
PGAPGA1_c12480(soxD2)
PGLPGA2_c12460(soxD2)
PGDGal_02157
PHPPhaeoP97_01244(soxD2)
PPICPhaeoP14_01167(soxD2)
PHQD1820_02270
OTMOSB_13250
OCTFTO60_10295
LMDMETH_07420
LEJETW24_08465
LAQUR2C4_10300 R2C4_12630
REDroselon_02252
CMARIMCC12053_765
CEHCEW89_07100
MALGMALG_03480
CONTQ29_11420
YPACCEW88_16480
YANAYJ57_01965
TPROGa0080559_TMP1022
PABYGa0080574_TMP1405
SULZC1J03_15070
SULIC1J05_07900
SULDB5M07_07545
SPOTG6548_05545
SMEDJNX03_16560
SINLDSM14862_01878
RMMROSMUCSMR3_02023
ROKRAK1035_1163
RIDRIdsm_01804
ROMEI983_17020
ROHFIU89_03900
AHTANTHELSMS3_02239
SAGUCDO87_03815
THAACFI11_15405
OCDFHY55_04245
MARUFIU81_10275
ROTFIV09_13400
MALUKU6B_10820
TGLHFZ77_05205
RSQRsph17025_3912
PDEPden_4156
PARUCYR75_11925
PARSDRW48_07295
PPANESD82_03380 ESD82_08195
PSANHGN31_09875
PTPRCA23_c17350(soxD2)
RSUNHU_02674(soxD)
RHMB5V46_11230
RHCRGUI_3431
DAAAKL17_3169
DONBSK21_10440
THWBMG03_14450
TECAKL02_013800
RBGBG454_05020
SALOEF888_14335
SEDIEBB79_03325
PSEBEOK75_07815
PAEDG5B38_17675
PAMOBAR1_03185
PGVSL003B_2701
CACTHZ995_11880
RBZB9057_03165
THASC6Y53_05120
CMAGCBW24_10490
FAQG5B39_08775
ACRAcry_3042
AMVACMV_33880(soxD)
KHAIFJ82_11060
ATIAL072_28005
SKTIGS68_23585
SMUCJL100_018855 JL100_025465
SROEJL101_021080
TIIDY252_12640
ELIOKO353_14425
HTLHPTL_0810(soxD)
THUGKNN16_13950
TTHTT_C1045
TTJTTHA1410(TTHA1410)
TTSThthe16_1421
TTLTtJL18_0637
TSCTSC_c21000
THCTCCBUS3UF1_6020
TOSTheos_1614
TAQTO73_0522
TBCA0O31_00631
TANTKNN15_02065
MRBMrub_2868
MREK649_08185
MSVMesil_3203 Mesil_3444
MTAIMtai_v1c02250
GPHGEMMAAP_02010 GEMMAAP_17325
GGRHKW67_18115
GBAJ421_1808
CPICpin_0341
CHIHGWR21_17395
COYHF329_13150
PROEH9L23_25335
SHGSph21_4718
MUHHYN43_007155
MRUBDEO27_030725
OLIFKG96_21390
CHUCHU_0560(soxD)
SLISlin_2734
SPIKEXU85_21755
SPIBG8759_32400
SRHOHH216_16055
DFEDfer_1616
RSIRunsl_0295
RUPDTQ70_12500
FAEFAES_1991
FIBA6C57_13700
ADDHUW48_17450
ASWUHUW51_11635
NMVNITMOv2_1999
NJANSJP_3283
NKFNkreftii_000669
 » show all
Reference
1  [PMID:11425697]
  Authors
Friedrich CG, Rother D, Bardischewsky F, Quentmeier A, Fischer J
  Title
Oxidation of reduced inorganic sulfur compounds by bacteria: emergence of a common mechanism?
  Journal
Appl Environ Microbiol 67:2873-82 (2001)
DOI:10.1128/AEM.67.7.2873-2882.2001
Reference
2  [PMID:15865447]
  Authors
Bardischewsky F, Quentmeier A, Rother D, Hellwig P, Kostka S, Friedrich CG
  Title
Sulfur dehydrogenase of Paracoccus pantotrophus: the heme-2 domain of the molybdoprotein cytochrome c complex is dispensable for catalytic activity.
  Journal
Biochemistry 44:7024-34 (2005)
DOI:10.1021/bi047334b
Reference
3  [PMID:28257465]
  Authors
Grabarczyk DB, Berks BC
  Title
Intermediates in the Sox sulfur oxidation pathway are bound to a sulfane conjugate of the carrier protein SoxYZ.
  Journal
PLoS One 12:e0173395 (2017)
DOI:10.1371/journal.pone.0173395
Other DBs
ExplorEnz - The Enzyme Database: 1.8.2.6
IUBMB Enzyme Nomenclature: 1.8.2.6
ExPASy - ENZYME nomenclature database: 1.8.2.6
BRENDA, the Enzyme Database: 1.8.2.6
LinkDB

DBGET integrated database retrieval system