KEGG   ORTHOLOGY: K22635
Entry
K22635            Tight     KO                                     
Symbol
CYP76AH3
Name
ferruginol monooxygenase / sugiol synthase [EC:1.14.14.60 1.14.14.65]
Pathway
map00904  Diterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R11951  ferruginol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (11-hydroxyferruginol forming)
R11977  ferruginol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (sugiol forming)
R11988  sugiol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (11-hydroxysugiol forming)
R11990  11-hydroxyferruginol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (11-hydroxysugiol forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K22635  CYP76AH3; ferruginol monooxygenase / sugiol synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K22635  CYP76AH3; ferruginol monooxygenase / sugiol synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.60  ferruginol monooxygenase
     K22635  CYP76AH3; ferruginol monooxygenase / sugiol synthase
    1.14.14.65  sugiol synthase
     K22635  CYP76AH3; ferruginol monooxygenase / sugiol synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP76 family
   K22635  CYP76AH3; ferruginol monooxygenase / sugiol synthase
Genes
SMIL: 131015109 131015114
AG: AMB36496(CYP76AH3)
Reference
  Authors
Guo J, Ma X, Cai Y, Ma Y, Zhan Z, Zhou YJ, Liu W, Guan M, Yang J, Cui G, Kang L, Yang L, Shen Y, Tang J, Lin H, Ma X, Jin B, Liu Z, Peters RJ, Zhao ZK, Huang L
  Title
Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones.
  Journal
New Phytol 210:525-34 (2016)
DOI:10.1111/nph.13790
  Sequence
LinkDB

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