ORTHOLOGY: K22699
Help
Entry
K22699 KO
Symbol
thi4
Name
sulfide-dependent adenosine diphosphate thiazole synthase [EC:
2.4.2.59
]
Pathway
map00730
Thiamine metabolism
map01100
Metabolic pathways
map01240
Biosynthesis of cofactors
Module
M00896
Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP
Reaction
R12026
NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00730 Thiamine metabolism
K22699 thi4; sulfide-dependent adenosine diphosphate thiazole synthase
Enzymes [BR:
ko01000
]
2. Transferases
2.4 Glycosyltransferases
2.4.2 Pentosyltransferases
2.4.2.59 sulfide-dependent adenosine diphosphate thiazole synthase
K22699 thi4; sulfide-dependent adenosine diphosphate thiazole synthase
BRITE hierarchy
Other DBs
COG:
COG1635
Genes
BBAR:
RHAL1_03078
CAUL:
KCG34_24290
MALU:
KU6B_16750
HMR:
Hipma_0421
DAV:
DESACE_08810
DMA:
DMR_31420
DCB:
C3Y92_06440
DGG:
DGI_1133
DMS:
E8L03_06730
DAF:
Desaf_0994
DSX:
GD604_13095
DSD:
GD606_19515
DLM:
DPPLL_35930
DOL:
Dole_2426
DAL:
Dalk_2394
DOV:
DSCO28_45120
DLI:
dnl_00920
(thiG)
DMM:
dnm_073520
(thiG)
DAO:
Desac_0998
DAX:
FDQ92_03460
DBR:
Deba_1981
DMP:
FAK_22910
TID:
Thein_1804
TOP:
TOPB45_0915
TCM:
HL41_01820
THET:
F1847_03705
CTHI:
THC_0653
TAV:
G4V39_01630
TMAI:
FVE67_08730
DAW:
HS1_000304
MZL:
GKS04_01765
DHR:
LGS26_09060
CLJ:
CLJU_c30580
CSQ:
CSCA_1812
CDRK:
B9W14_10240
CFER:
D4Z93_11890
CLOS:
DMR38_15480
DKU:
Desku_1659
DAU:
Daud_0859
TJR:
TherJR_1442
ADG:
Adeg_0421
Adeg_1609
GEK:
kuro4_04070
MBX:
BCGT_0584
MPHL:
MPHLCCUG_05062
(ksdD_3)
SLK:
SLUN_34370
TNR:
Thena_0778
TACI:
TDSAC_0747
HBS:
IPV69_04150
VAI:
BU251_06310
BU251_06360
TAI:
Taci_1358
TLI:
Tlie_1851
AMO:
Anamo_0225
BCEL:
BcellWH2_01838
BIS:
DXK01_001245
PSOE:
CE91St14_02970
PDI:
BDI_1609
PARC:
CI960_06610
PMER:
INE87_00229
PGOL:
K6V26_06880
PJO:
LK449_05640
PFAI:
NXY11_05335
PMZ:
HMPREF0659_A5800
PIT:
PIN17_A0608
PNI:
J5A59_03980
PHER:
prwr041_11060
PSCJ:
J4856_09105
PBIV:
QP022_05995
RBC:
BN938_1539
TTZ:
FHG85_07515
MBAS:
ALGA_3764
PAA:
Paes_1007
PROC:
Ptc2401_01068
PRS:
B9H02_06355
PROS:
CHL67_06345
TAM:
Theam_0077
DTE:
Dester_1473
TTK:
TST_0727
(thi1)
TMA:
TM0787
TMM:
Tmari_0788
TMI:
THEMA_00715
TMW:
THMA_0806
TMQ:
THMB_0806
TMX:
THMC_0806
TPT:
Tpet_0142
TNP:
Tnap_0143
TRQ:
TRQ2_0140
TNA:
CTN_1791
THQ:
T2812B_00715
THZ:
CELL2_00740
THR:
TRQ7_00715
TLE:
Tlet_1750
TTA:
Theth_1374
TME:
Tmel_1590
TAF:
THA_1798
THP:
BG95_08660
THER:
Y592_08765
FNO:
Fnod_1422
FPE:
Ferpe_0640
FIA:
NA23_03490
FRR:
IB67_05365
NDE:
NIDE1062
NMV:
NITMOv2_0947
NIO:
NITINOP_1921
NJA:
NSJP_2079
NKF:
Nkreftii_003088
NIF:
W02_33410
NTI:
DNFV4_01351
NALL:
PP769_00420
NNEO:
PQG83_11585
FSH:
Q2T83_00155
MJA:
MJ_0601
MFE:
Mefer_1385
MVU:
Metvu_1585
MFS:
MFS40622_1580
MIF:
Metin_1281
MJH:
JH146_0825
MESG:
MLAUSG7_1377
(thi)
MESA:
MLASG1_0803
(thi)
MIG:
Metig_0735
Metig_1112
MMP:
MMP1352
MMQ:
MmarC5_0226
MMX:
MmarC6_1321
MMZ:
MmarC7_0597
MMAK:
MMKA1_15750
MMAO:
MMOS7_14560
MMAD:
MMJJ_14870
MAE:
Maeo_0798
MVN:
Mevan_0663
MVO:
Mvol_0738
MOK:
Metok_0500
METF:
CFE53_00030
MTH:
MTH_1620
MMG:
MTBMA_c02060
MWO:
MWSIV6_0166
(Thi4)
MTEE:
MTTB_13720
METC:
MTCT_1479
METE:
tca_01569
METZ:
METMT2_1460
METK:
FVF72_03520
MTHM:
FZP57_00720
METJ:
FZP68_05735
MEB:
Abm4_1461
MEL:
Metbo_0536
Metbo_1265
MEW:
MSWAN_0974
MSWAN_1853
METH:
MBMB1_1137
MBMB1_1486
MFC:
BRM9_0713
BRM9_1347
MFI:
DSM1535_0665
DSM1535_2031
MCUB:
MCBB_1020
MCBB_1725
MSUB:
BK009_06380
METN:
BK008_01970
METT:
CIT01_06780
METO:
CIT02_02510
CIT02_10600
MEME:
HYG87_01485
HYG87_07505
MFEG:
GCM10025860_28950
MEER:
NKF70_04100
NKF70_14305
MFV:
Mfer_0175
MKA:
MK0430
AFU:
AF_0702
AFG:
AFULGI_00007840
APO:
Arcpr_1423
AVE:
Arcve_1405
AST:
Asulf_00980
FPL:
Ferp_0628
GAC:
GACE_0145
GAH:
GAH_01007
PFU:
PF1530
PFI:
PFC_06880
PHO:
PH1357
(PH1357)
PAB:
PAB0536
(thi1)
PYN:
PNA2_1583
PNA2_1941
PYA:
PYCH_06240
PYCH_08650
PYS:
Py04_1231
PYC:
TQ32_10505
TKO:
TK0434
TGA:
TGAM_1270
THE:
GQS_02015
THM:
CL1_0036
TLT:
OCC_06556
THS:
TES1_1982
TNU:
BD01_0513
TEU:
TEU_09505
TGY:
X802_10050
THV:
ADU37_CDS17350
ADU37_CDS22280
TCH:
CHITON_1554
TPEP:
A0127_02260
TPIE:
A7C91_09070
TCE:
A3L02_01985
TTD:
A3L14_05500
TPRF:
A3L09_06395
TPAF:
A3L08_06895
THY:
A3L12_03095
TIC:
FH039_06460
TCQ:
TIRI35C_0994
(thi)
THEM:
FPV09_02920
PPAC:
PAP_08770
MBA:
Mbar_A2100
MBY:
MSBRM_2409
MBW:
MSBRW_2643
MBAR:
MSBR2_2375
MBAK:
MSBR3_2431
MAC:
MA_2851
MMA:
MM_0222
MMAZ:
MmTuc01_0227
MMJ:
MSMAS_1078
MMAC:
MSMAC_2441
MVC:
MSVAZ_1117
MEK:
MSKOL_1072
MLS:
MSLAZ_1169
METM:
MSMTP_1119
MEF:
MSWH1_1762
MEQ:
MSWHS_1554
MSJ:
MSSAC_2840
MSZ:
MSSIH_2497
MSW:
MSSIT_2540
MTHR:
MSTHT_0054
MTHE:
MSTHC_0676
MHOR:
MSHOH_1299
MFZ:
AOB57_002245
MBU:
Mbur_2109
MMET:
MCMEM_0306
MCMEM_0840
MELO:
J7W08_02430
J7W08_11625
MMH:
Mmah_0298
MHAZ:
BHR79_02030
MPOT:
BKM01_06375
MEV:
Metev_0188
MZH:
Mzhil_1372
MZI:
HWN40_08730
MMAV:
RE476_01435
MSEB:
RE474_11125
MTP:
Mthe_1121
MCJ:
MCON_3229
MHI:
Mhar_2378
MHU:
Mhun_1935
MRTJ:
KHC33_14740
MLA:
Mlab_0277
MEM:
Memar_2251
MBG:
BN140_1460
(thi1)
MEMA:
MMAB1_1869
MCHK:
MchiMG62_25690
MSUM:
OH143_05540
MRC:
R6Y96_03785
MPI:
Mpet_0116
MEND:
L6E24_07545
MEFW:
F1737_10475
MAQE:
RJ40_07140
MFK:
E2N92_07295
MOU:
OU421_07750
MESB:
L1S32_11135
MANQ:
L1994_01520
MFO:
Metfor_0238
MEZ:
Mtc_1604
(thi4-1)
Mtc_2398
(thi4-2)
MJK:
N2V74_02430
N2V74_03430
HAL:
VNG_2604G
(thi1)
HSL:
OE_4651F
(thi4)
HANR:
LJ422_10530
HHB:
Hhub_1122
(thi4)
HAGS:
JT689_11965
HABO:
JRZ79_10305
HNO:
LT974_00705
HLU:
LT972_12875
HSU:
HLASF_0331
HSF:
HLASA_0330
SALR:
FQU85_03530
HALR:
EFA46_011875
HJE:
HacjB3_12970
HDO:
MUK72_07875
HALX:
M0R89_10525
HAXZ:
M0R88_11005
HAYC:
NGM10_05370
HAXY:
NGM07_01030
SALI:
L593_09560
SAIM:
K0C01_03160
HARA:
AArcS_1966
(thi4)
HMA:
rrnAC1782
(thi1)
HHI:
HAH_2313
(thi1)
HHN:
HISP_11780
HAB:
SG26_04110
HTA:
BVU17_11255
HALJ:
G9465_07010
HSIN:
KDQ40_01865
NPH:
NP_5174A
(thi4)
NMO:
Nmlp_3882
(thi4)
NHO:
HWV23_12010
NSAL:
HWV07_14560
HUT:
Huta_2718
HTI:
HTIA_2465
HALA:
Hrd1104_02040
HASV:
SVXHr_1858
(thi4)
HABN:
HBNXHr_1846
(thi4)
HMU:
Hmuk_0002
HALZ:
E5139_03335
HALL:
LC1Hm_2563
(thi4)
HAZP:
GBQ70_03335
HALI:
BV210_05585
HSN:
DV733_09670
HDS:
HSR122_2321
(thi4)
HRR:
HZS55_08655
HPEL:
HZS54_09780
HLT:
I7X12_05325
HARC:
HARCEL1_09615
HAAD:
MW046_08650
HWA:
HQ_1276A
(thi4)
HWC:
Hqrw_1306
(thi4)
HVO:
HVO_0665
(thi4)
HALE:
G3A49_03390
HLN:
SVXHx_0624
(thi4)
HME:
HFX_0634
HGI:
ABY42_03175
HLS:
KU306_07905
HBO:
Hbor_25460
HAQ:
DU484_06390
HAJ:
DU500_06660
HAER:
DU502_04335
HRA:
EI982_09275
HLM:
DV707_12630
HLA:
Hlac_2980
HALB:
EKH57_08560
HEZZ:
EO776_03960
HALQ:
Hrr1229_002890
HSS:
J7656_12905
HSAI:
HPS36_03250
HAZZ:
KI388_01415
SRUB:
C2R22_02145
HAE:
halTADL_1093
HALN:
B4589_006725
HALG:
HUG10_03970
HALU:
HUG12_12960
HMP:
K6T50_02080
HRE:
K6T36_01900
HRM:
K6T25_14540
HACB:
Hbl1158_08970
HDF:
AArcSl_1355
(thi4)
HAH:
Halar_3704
HTU:
Htur_1462
HSAL:
JMJ58_01385
HAKZ:
J0X25_14155
NMG:
Nmag_2419
(thi4)
HXA:
Halxa_2863
NAT:
NJ7G_3680
NPE:
Natpe_2830
NVR:
FEJ81_13195
NPL:
FGF80_13125
NAY:
HYG81_16885
HALY:
HYG82_19015
HJT:
DVR14_04265
HLO:
J0X27_03870
NGE:
Natgr_0926
HRU:
Halru_1150
SAWL:
NGM29_17530
HALV:
NGM15_08750
NOU:
Natoc_0532
HLR:
HALLA_10200
HLC:
CHINAEXTREME16945
NAJ:
B1756_03455
NAG:
AArcMg_1121
NAN:
AArc1_2501
NARA:
QQ977_09420
NBG:
DV706_12525
NAS:
GCU68_13250
HDA:
BB347_01930
MELU:
MTLP_07010
MEAM:
MU439_01690
MEAE:
QEN48_00685
ABI:
Aboo_0963
ACF:
AciM339_1016
APE:
APE_2149.1
ACJ:
ACAM_1344
SMR:
Smar_0052
Smar_0180
SHC:
Shell_0764
IHO:
Igni_0560
IIS:
EYM_05510
IPC:
IPA_05695
DKA:
DKAM_0713
DFD:
Desfe_0795
IAG:
Igag_0295
THG:
TCELL_1023
HBU:
Hbut_0253
PFM:
Pyrfu_0366
PDL:
Pyrde_0220
Pyrde_0347
PABI:
PABY_00710
STO:
STK_03610
SOH:
D1869_01525
SSO:
SSO0436
SOL:
Ssol_1411
SSOA:
SULA_1456
SSOL:
SULB_1457
SSOF:
SULC_1455
SSHI:
J5U23_03002
SCAS:
SACC_05940
SAI:
Saci_0854
(thi)
SACN:
SacN8_04145
SACR:
SacRon12I_04135
SACS:
SUSAZ_03885
SIS:
LS215_1798
SIA:
M1425_1670
SIM:
M1627_1786
SID:
M164_1717
SIY:
YG5714_1786
SIN:
YN1551_1140
SII:
LD85_1927
SIH:
SiH_1645
SIR:
SiRe_1566
SIC:
SiL_1558
SULA:
BFU36_03640
SULE:
GFS03_09395
SULO:
GFS33_01210
SULL:
EWF20_02995
MSE:
Msed_2221
MEMJ:
MJ1HA_2541
MCN:
Mcup_0086
MHK:
DFR87_07430
MPRU:
DFR88_07115
MTEN:
GWK48_04735
MJN:
MjAS7_0513
AHO:
Ahos_0692
AMAN:
B6F84_06895
ABRI:
DFR85_08045
ASUL:
DFR86_05955
AAMB:
D1866_11245
ACIH:
HS5_20660
SACD:
HS1genome_2409
SAZO:
D1868_02625
CSTY:
KN1_20130
STEP:
IC006_1529
SMET:
RQ359_000407
SAHS:
HS7_05390
PAI:
PAE0175
PIS:
Pisl_1998
PCL:
Pcal_1555
PAS:
Pars_1498
PYR:
P186_0936
POG:
Pogu_0708
TNE:
Tneu_1052
PYW:
PYWP30_02101
CMA:
Cmaq_1420
TUZ:
TUZN_0079
VDI:
Vdis_2373
VMO:
VMUT_0723
VSO:
Vsou_21150
FFO:
FFONT_0392
KCR:
Kcr_0795
NMR:
Nmar_0678
NIR:
NSED_03435
NKR:
NKOR_03495
NID:
NPIRD3C_1584
NIN:
NADRNF5_1474
NIW:
Nisw_01510
NCL:
C5F47_05695
NOX:
C5F49_05585
NUE:
C5F50_04895
NIP:
NsoK4_05025
NZT:
NZOSNM25_001293
NCT:
NMSP_1025
NIC:
DSQ20_03585
NGA:
Ngar_c21660
NVN:
NVIE_008130
NEV:
NTE_02257
TAA:
NMY3_02935
NFN:
NFRAN_0414
(thi)
NCV:
NCAV_0396
(thi)
CSY:
CENSYa_0361
NBV:
T478_0555
TAH:
SU86_002805
NIU:
DSQ19_03795
NDV:
NDEV_0758
CCAI:
NAS2_0821
BARB:
AOA66_0043
FLT:
Sv326_1000
» show all
Taxonomy
UniProt
Reference
PMID:
26928142
Authors
Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE
Title
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
Journal
J Am Chem Soc 138:3639-42 (2016)
DOI:
10.1021/jacs.6b00445
Sequence
[mja:
MJ_0601
]
Reference
PMID:
25348237
Authors
Hwang S, Cordova B, Chavarria N, Elbanna D, McHugh S, Rojas J, Pfeiffer F, Maupin-Furlow JA
Title
Conserved active site cysteine residue of archaeal THI4 homolog is essential for thiamine biosynthesis in Haloferax volcanii.
Journal
BMC Microbiol 14:260 (2014)
DOI:
10.1186/s12866-014-0260-0
Sequence
[hvo:
HVO_0665
]
LinkDB
All DBs
DBGET
integrated database retrieval system