KEGG   ORTHOLOGY: K22699
Entry
K22699                      KO                                     
Symbol
thi4
Name
sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]
Pathway
map00730  Thiamine metabolism
map01100  Metabolic pathways
map01240  Biosynthesis of cofactors
Module
M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP
Reaction
R12026  NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00730 Thiamine metabolism
    K22699  thi4; sulfide-dependent adenosine diphosphate thiazole synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.59  sulfide-dependent adenosine diphosphate thiazole synthase
     K22699  thi4; sulfide-dependent adenosine diphosphate thiazole synthase
Other DBs
COG: COG1635
Genes
BBAR: RHAL1_03078
CAUL: KCG34_24290
MALU: KU6B_16750
HMR: Hipma_0421
DAV: DESACE_08810
DMA: DMR_31420
DCB: C3Y92_06440
DGG: DGI_1133
DMS: E8L03_06730
DAF: Desaf_0994
DOL: Dole_2426
DAL: Dalk_2394
DLI: dnl_00920(thiG)
DMM: dnm_073520(thiG)
DBR: Deba_1981
DMP: FAK_22910
CTHI: THC_0653
CSQ: CSCA_1812
DAU: Daud_0859
MBX: BCGT_0584
MPHL: MPHLCCUG_05062(ksdD_3)
TACI: TDSAC_0747
TAI: Taci_1358
TLI: Tlie_1851
PDI: BDI_1609
MBAS: ALGA_3764
PAA: Paes_1007
TTK: TST_0727(thi1)
TMA: TM0787
TMW: THMA_0806
TMQ: THMB_0806
TMX: THMC_0806
TPT: Tpet_0142
TNP: Tnap_0143
TRQ: TRQ2_0140
TNA: CTN_1791
TLE: Tlet_1750
TME: Tmel_1590
TAF: THA_1798
THER: Y592_08765
FNO: Fnod_1422
NDE: NIDE1062
NJA: NSJP_2079
NIF: W02_33410
MJA: MJ_0601
MESG: MLAUSG7_1377(thi)
MESA: MLASG1_0803(thi)
MMP: MMP1352
MMAD: MMJJ_14870
MAE: Maeo_0798
MVO: Mvol_0738
MTH: MTH_1620
MWO: MWSIV6_0166(Thi4)
MTEE: MTTB_13720
METC: MTCT_1479
METE: tca_01569
MEB: Abm4_1461
MFV: Mfer_0175
MKA: MK0430
AFU: AF_0702
FPL: Ferp_0628
GAC: GACE_0145
GAH: GAH_01007
PFU: PF1530
PFI: PFC_06880
PHO: PH1357(PH1357)
PAB: PAB0536(thi1)
PYS: Py04_1231
TKO: TK0434
TGA: TGAM_1270
THE: GQS_02015
THM: CL1_0036
TLT: OCC_06556
THS: TES1_1982
TNU: BD01_0513
TEU: TEU_09505
TCQ: TIRI35C_0994(thi)
PPAC: PAP_08770
MBAR: MSBR2_2375
MBAK: MSBR3_2431
MAC: MA_2851
MMA: MM_0222
MMAC: MSMAC_2441
METM: MSMTP_1119
MTHR: MSTHT_0054
MTHE: MSTHC_0676
MHOR: MSHOH_1299
MBU: Mbur_2109
MMH: Mmah_0298
MTP: Mthe_1121
MCJ: MCON_3229
MHI: Mhar_2378
MHU: Mhun_1935
MLA: Mlab_0277
MBG: BN140_1460(thi1)
MEMA: MMAB1_1869
MPI: Mpet_0116
MAQE: RJ40_07140
MEZ: Mtc_1604(thi4-1) Mtc_2398(thi4-2)
HAL: VNG_2604G(thi1)
HSL: OE_4651F(thi4)
HHB: Hhub_1122(thi4)
SALI: L593_09560
HARA: AArcS_1966(thi4)
HMA: rrnAC1782(thi1)
HHI: HAH_2313(thi1)
NPH: NP_5174A(thi4)
NMO: Nmlp_3882(thi4)
HUT: Huta_2718
HTI: HTIA_2465
HASV: SVXHr_1858(thi4)
HABN: HBNXHr_1846(thi4)
HMU: Hmuk_0002
HALL: LC1Hm_2563(thi4)
HDS: HSR122_2321(thi4)
HWA: HQ_1276A(thi4)
HWC: Hqrw_1306(thi4)
HVO: HVO_0665(thi4)
HLN: SVXHx_0624(thi4)
HME: HFX_0634
HLA: Hlac_2980
HDF: AArcSl_1355(thi4)
HTU: Htur_1462
NMG: Nmag_2419(thi4)
NAT: NJ7G_3680
MELU: MTLP_07010
ABI: Aboo_0963
ACJ: ACAM_1344
IHO: Igni_0560
IIS: EYM_05510
IPC: IPA_05695
DKA: DKAM_0713
IAG: Igag_0295
HBU: Hbut_0253
PABI: PABY_00710
STO: STK_03610
SSO: SSO0436
SOL: Ssol_1411
SSOA: SULA_1456
SSOL: SULB_1457
SSOF: SULC_1455
SCAS: SACC_05940
SAI: Saci_0854(thi)
SID: M164_1717
SII: LD85_1927
SIH: SiH_1645
SIR: SiRe_1566
SIC: SiL_1558
MSE: Msed_2221
MEMJ: MJ1HA_2541
MCN: Mcup_0086
AHO: Ahos_0692
ACIH: HS5_20660
CSTY: KN1_20130
STEP: IC006_1529
SAHS: HS7_05390
PAI: PAE0175
PIS: Pisl_1998
PCL: Pcal_1555
PAS: Pars_1498
PYR: P186_0936
POG: Pogu_0708
TNE: Tneu_1052
CMA: Cmaq_1420
TUZ: TUZN_0079
VDI: Vdis_2373
VMO: VMUT_0723
KCR: Kcr_0795
NMR: Nmar_0678
NCT: NMSP_1025
NEV: NTE_02257
NFN: NFRAN_0414(thi)
NCV: NCAV_0396(thi)
NBV: T478_0555
NDV: NDEV_0758
CCAI: NAS2_0821
BARB: AOA66_0043
 » show all
Reference
  Authors
Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE
  Title
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
  Journal
J Am Chem Soc 138:3639-42 (2016)
DOI:10.1021/jacs.6b00445
  Sequence
[mja:MJ_0601]
Reference
  Authors
Hwang S, Cordova B, Chavarria N, Elbanna D, McHugh S, Rojas J, Pfeiffer F, Maupin-Furlow JA
  Title
Conserved active site cysteine residue of archaeal THI4 homolog is essential for thiamine biosynthesis in Haloferax volcanii.
  Journal
BMC Microbiol 14:260 (2014)
DOI:10.1186/s12866-014-0260-0
  Sequence
[hvo:HVO_0665]
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