KEGG   ORTHOLOGY: K22729
Entry
K22729                      KO                                     
Symbol
HELC
Name
helvolic acid biosynthesis dehydrogenase/reductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09190 Not Included in Pathway or Brite
  09191 Unclassified: metabolism
   99988 Secondary metabolism
    K22729  HELC; helvolic acid biosynthesis dehydrogenase/reductase
Other DBs
COG: COG1028
Genes
MAJ: MAA_06588
MBRN: 26246763(helC)
AFM: AFUA_4G14800
NFI: NFIA_101390
Reference
  Authors
Mitsuguchi H, Seshime Y, Fujii I, Shibuya M, Ebizuka Y, Kushiro T
  Title
Biosynthesis of steroidal antibiotic fusidanes: functional analysis of oxidosqualene cyclase and subsequent tailoring enzymes from Aspergillus fumigatus.
  Journal
J Am Chem Soc 131:6402-11 (2009)
DOI:10.1021/ja8095976
  Sequence
Reference
  Authors
Lv JM, Hu D, Gao H, Kushiro T, Awakawa T, Chen GD, Wang CX, Abe I, Yao XS
  Title
Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis.
  Journal
Nat Commun 8:1644 (2017)
DOI:10.1038/s41467-017-01813-9
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