ORTHOLOGY: K22729
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Entry
K22729 KO
Symbol
HELC
Name
helvolic acid biosynthesis dehydrogenase/reductase
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09190 Not Included in Pathway or Brite
09191 Unclassified: metabolism
99988 Secondary metabolism
K22729 HELC; helvolic acid biosynthesis dehydrogenase/reductase
BRITE hierarchy
Other DBs
COG:
COG1028
Genes
MAJ:
MAA_06588
MBRN:
26246763
(helC)
AFM:
AFUA_4G14800
NFI:
NFIA_101390
Taxonomy
UniProt
Reference
PMID:
19415934
Authors
Mitsuguchi H, Seshime Y, Fujii I, Shibuya M, Ebizuka Y, Kushiro T
Title
Biosynthesis of steroidal antibiotic fusidanes: functional analysis of oxidosqualene cyclase and subsequent tailoring enzymes from Aspergillus fumigatus.
Journal
J Am Chem Soc 131:6402-11 (2009)
DOI:
10.1021/ja8095976
Sequence
[afm:
AFUA_4G14800
]
Reference
PMID:
29158519
Authors
Lv JM, Hu D, Gao H, Kushiro T, Awakawa T, Chen GD, Wang CX, Abe I, Yao XS
Title
Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis.
Journal
Nat Commun 8:1644 (2017)
DOI:
10.1038/s41467-017-01813-9
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