KEGG   ORTHOLOGY: K22732
Entry
K22732                      KO                                     
Symbol
HELE
Name
helvolic acid biosynthesis 3-ketosteroid Delta1-dehydrogenase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09190 Not Included in Pathway or Brite
  09191 Unclassified: metabolism
   99988 Secondary metabolism
    K22732  HELE; helvolic acid biosynthesis 3-ketosteroid Delta1-dehydrogenase
Other DBs
COG: COG1053
Genes
FPOA: FPOAC1_012942 FPOAC1_013017 FPOAC1_013210 FPOAC1_013267 FPOAC1_013288 FPOAC1_013563 FPOAC1_013585 FPOAC1_013665 FPOAC1_013679 FPOAC1_013838 FPOAC1_013867
NHE: NECHADRAFT_56510
FFC: NCS54_00910600 NCS54_01507200
FKR: NCS57_00928800 NCS57_01378100 NCS57_01491500
MAW: MAC_07016
MAJ: MAA_06591 MAA_08883
CFJ: CFIO01_05280
CLUP: CLUP02_04661
AFM: AFUA_4G14850
NFI: NFIA_101440
ABE: ARB_05032
TVE: TRV_01466
 » show all
Reference
  Authors
Mitsuguchi H, Seshime Y, Fujii I, Shibuya M, Ebizuka Y, Kushiro T
  Title
Biosynthesis of steroidal antibiotic fusidanes: functional analysis of oxidosqualene cyclase and subsequent tailoring enzymes from Aspergillus fumigatus.
  Journal
J Am Chem Soc 131:6402-11 (2009)
DOI:10.1021/ja8095976
  Sequence
Reference
  Authors
Lv JM, Hu D, Gao H, Kushiro T, Awakawa T, Chen GD, Wang CX, Abe I, Yao XS
  Title
Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis.
  Journal
Nat Commun 8:1644 (2017)
DOI:10.1038/s41467-017-01813-9
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