KEGG ORTHOLOGY: K22830

ORTHOLOGY: K22830

Entry

K22830                      KO

Symbol

SMDT1, EMRE

Name

essential MCU regulator, mitochondrial

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K22830  SMDT1, EMRE; essential MCU regulator, mitochondrial
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial protein import machinery
  Inner mambrane
   Mitochondrial calcium uniporter complex
    K22830  SMDT1, EMRE; essential MCU regulator, mitochondrial

Other DBs

TC:

8.A.45.1

Genes

HSA:	91689(SMDT1)

PTR:	746097(SMDT1)

PPS:	100993103(SMDT1)

GGO:	101134016(SMDT1)

PON:	100458161(SMDT1)

PPYG:

129023341(SMDT1)

NLE:	100579376(SMDT1)

HMH:	116458808(SMDT1)

SSYN:

129468066(SMDT1)

MCC:	709741(SMDT1)

MCF:	101926580(SMDT1)

MTHB:

126963676

MNI:	105464353(SMDT1)

CSAB:

103223409(SMDT1)

CATY:

105572177(SMDT1)

PANU:

101011847 101013488(SMDT1)

TGE:	112632628(SMDT1)

RRO:	104670336(SMDT1)

RBB:	108543565(SMDT1)

TFN:	117096392(SMDT1)

PTEH:

111548939(SMDT1)

CANG:

105514020(SMDT1)

CJC:	100386902(SMDT1)

SBQ:	101051950(SMDT1)

CIMI:

108290472(SMDT1)

ANAN:

110567843(SMDT1) 135271273

CSYR:

103264349(SMDT1)

MMUR:

105858590(SMDT1)

LCAT:

123640285(SMDT1)

PCOQ:

105805268(SMDT1)

OGA:	100954244(SMDT1)

MMU:	69029(Smdt1)

MCAL:

110310653(Smdt1)

MPAH:

110335014(Smdt1)

RNO:	134483672 315166(Smdt1)

MCOC:

116076704(Smdt1)

ANU:	117719095(Smdt1)

ASYL:

127668217(Smdt1)

MUN:	110554105(Smdt1)

CGE:	100751090(Smdt1)

MAUA:

101844261(Smdt1)

PROB:

127225861(Smdt1)

PLEU:

114694321(Smdt1)

MORG:

121461195(Smdt1)

MFOT:

126515721

AAMP:

119823535(Smdt1)

NGI:	103743457(Smdt1)

HGL:	101725774(Smdt1)

CPOC:

100713934(Smdt1)

CCAN:

109689364(Smdt1)

DORD:

105991966(Smdt1)

DSP:	122123542(Smdt1)

PLOP:

125357549(Smdt1)

NCAR:

124982313

MMMA:

107155830(Smdt1)

ITI:	101960147(Smdt1)

OCU:

100349541

OPI:	101535857(SMDT1)

TUP:	102490032(SMDT1)

GVR:	103591825(SMDT1)

CFA:	609643(SMDT1)

CLUD:

112666746(SMDT1)

VVP:	112933986(SMDT1)

VLG:	121490801(SMDT1)

NPO:	129511721(SMDT1)

AML:	100471712(SMDT1)

UMR:	103674069(SMDT1)

UAH:	113241709(SMDT1)

UAR:	123780548(SMDT1)

ELK:

111157618

LLV:

125106376

MPUF:

101674111(SMDT1)

MNP:	132019164(SMDT1)

MLK:	131839560(SMDT1)

NVS:	122892579(SMDT1)

ORO:	101380573(SMDT1)

EJU:	114218374(SMDT1)

ZCA:	113921592(SMDT1)

MLX:	117998613(SMDT1)

NSU:	110578243(SMDT1)

LWW:	102741502(SMDT1)

FCA:	101083780(SMDT1)

PYU:	121040248(SMDT1)

PCOO:

112863537(SMDT1)

PBG:	122472846(SMDT1)

PVIV:

125170495(SMDT1)

LRUF:

124502208

LGF:	123590017(SMDT1)

AJU:

113602704

PTG:	102963082(SMDT1)

PPAD:

109265654(SMDT1)

PUC:

125920385

PLEZ:

122225205(SMDT1)

HHV:	120235151(SMDT1)

BTA:	506149(SMDT1)

BOM:	102280730(SMDT1)

BIU:	109559876(SMDT1)

BBUB:

102406208(SMDT1)

BBIS:

104991250(SMDT1)

CHX:	102171695(SMDT1)

OAS:	101105406(SMDT1)

BTAX:

128048312(SMDT1)

CSUM:

138078518(SMDT1)

ODA:	120857578(SMDT1)

CCAD:

122423358(SMDT1)

MREE:

136174707(SMDT1)

OVR:	110126934(SMDT1)

MBEZ:

129536258(SMDT1)

SSC:	100737924(SMDT1)

CFR:	102511181(SMDT1)

CBAI:

105073058(SMDT1)

CDK:	105091881(SMDT1)

VPC:	102542074(SMDT1)

BACU:

103006531(SMDT1)

BMUS:

118901633(SMDT1)

LVE:	103071832(SMDT1) 103089341

OOR:	101272706(SMDT1) 101288238

LALB:

132509453 132528867(SMDT1)

DLE:	111186392(SMDT1)

PCAD:

102996601(SMDT1)

PSIU:

116738773 116760281(SMDT1)

NASI:

112394717(SMDT1)

ECB:	100056050(SMDT1)

EPZ:	103541992(SMDT1)

EAI:	106848495(SMDT1)

MYB:	102258578(SMDT1)

MYD:	102753559(SMDT1)

MMYO:

118651855(SMDT1) 118677517

MLF:	102421698(SMDT1)

MDT:	132225846(SMDT1)

MYUM:

139007624(SMDT1)

PKL:	118712081(SMDT1) 118731611

EFUS:

103283731 103288814(SMDT1)

MNA:	107534965(SMDT1)

DRO:	112321784(SMDT1)

SHON:

119002462(SMDT1)

AJM:	119060176(SMDT1)

PDIC:

114513500(SMDT1)

PHAS:

123816180(SMDT1)

MMF:	118624218(SMDT1)

PPAM:

129077878(SMDT1)

HAI:	109371484(SMDT1)

RFQ:	117029430(SMDT1)

PALE:

102887939(SMDT1)

PGIG:

120602940(SMDT1)

PVP:	105298027(SMDT1)

RAY:	107505570(SMDT1)

MJV:	108387113(SMDT1)

TOD:	119247196(SMDT1)

SARA:

101545756(SMDT1)

SFUM:

130044869(SMDT1)

SETR:

126006344(SMDT1)

LAV:	100656627(SMDT1)

TMU:

101341085

ETF:	101653004(SMDT1)

DNM:	101411034(SMDT1)

MDO:	100011990(SMDT1)

GAS:	123249272(SMDT1)

SHR:

100927292

AFZ:

127538483

PCW:	110205860(SMDT1)

TVP:	118851554(SMDT1) 118853310

PBRV:

138156598(SMDT1)

OAA:	100086828(SMDT1)

TACU:

119937105(SMDT1) 119948139

GGA:	770755(SMDT1)

PCOC:

116233410(SMDT1)

MGP:	100549094(SMDT1)

CJO:	107313289(SMDT1)

TPAI:

128073461(SMDT1)

LMUT:

125687962(SMDT1)

NMEL:

110391290(SMDT1)

APLA:

113843133(SMDT1)

ACYG:

136789673(SMDT1)

CATA:

118246819(SMDT1)

AFUL:

116501962(SMDT1)

TGU:	105758571(SMDT1)

LSR:	110483088(SMDT1)

SCAN:

103813620(SMDT1)

PMOA:

120510066(SMDT1)

OTC:	121342316(SMDT1)

PRUF:

121361075(SMDT1)

ATRC:

139588086(SMDT1)

FAB:	101821233(SMDT1)

OMA:	130262292(SMDT1)

PHI:	102107907(SMDT1)

PMAJ:

107204593(SMDT1)

CCW:	104696360(SMDT1)

ACOE:

138103916(SMDT1)

ETL:	114058077(SMDT1)

ZLE:	135442465(SMDT1)

SVG:	106856935(SMDT1)

MMEA:

130588387(SMDT1)

HRT:	120751736(SMDT1)

SATI:

136361712(SMDT1)

CCIC:

134043647(SMDT1)

SHAB:

115605359(SMDT1)

ACUN:

113488092(SMDT1)

TALA:

104358553(SMDT1)

ACHC:

115352691(SMDT1)

HLE:	104828535(SMDT1)

AGEN:

126047864

HHAR:

128143295(SMDT1)

GCL:

127024088

DPUB:

104302074(SMDT1)

PPUS:

135181764(SMDT1)

NNI:	104021711(SMDT1)

PADL:

103915845(SMDT1)

CBOY:

140654555(SMDT1)

PGUU:

104460910(SMDT1)

CUCA:

104055529(SMDT1)

BREG:

104640183(SMDT1)

OHA:	104329889(SMDT1)

CPEA:

104387607(SMDT1)

CVF:	104295509(SMDT1)

RTD:	128900193(SMDT1)

CRID:

134509901(SMDT1)

AAM:	106488217(SMDT1)

AROW:

112967698(SMDT1)

DNE:	112984145(SMDT1)

ASN:	102374655(SMDT1)

AMJ:	102560591(SMDT1)

CPOO:

109316756(SMDT1)

GGN:	109295925(SMDT1)

PSS:	102462666(SMDT1)

CMY:	102929374(SMDT1)

CCAY:

125629952(SMDT1)

DCC:	119858297(SMDT1)

CPIC:

101950762(SMDT1)

TST:	117879742(SMDT1)

CABI:

116828634(SMDT1)

MRV:	120376582(SMDT1)

ACS:	100558742(smdt1)

ASAO:

132776004(SMDT1)

PVT:	110076018(SMDT1)

SUND:

121930852(SMDT1)

PBI:	103051413(SMDT1)

PMUR:

107285346(SMDT1)

CTIG:

120304709(SMDT1)

PGUT:

117655868(SMDT1)

APRI:

131202695(SMDT1)

PTEX:

113434244(SMDT1)

NSS:	113432675(SMDT1)

PMUA:

114605258(SMDT1)

PRAF:

128422540(SMDT1)

ZVI:	118091463(SMDT1)

HCG:	128326239(SMDT1)

GJA:	107123625(SMDT1)

STOW:

125434763(SMDT1)

EMC:	129335563(SMDT1)

XLA:	108714476(smdt1.L) 495205(smdt1.S)

XTR:	496604(smdt1)

NPR:	108801792(SMDT1)

BGAR:

122935851(SMDT1)

PWL:	138292525(SMDT1)

MUO:	115460137(SMDT1)

GSH:	117355946(SMDT1)

DRE:	100000862(smdt1b) 137490269(smdt1)

SRX:	107721686 107746113

SANH:

107700869 107703822

SGH:	107574643 107594281 107598503

CCAR:

109066721 109102192(smdt1b) 122135849

CAUA:

113055616 113058467 113076683 113097584

CGIB:

127949204 127956516 128019990

PTET:

122339740 122355111(smdt1b)

LROH:

127162412 127168967(smdt1b)

OMC:	131536157(smdt1b) 131536583

PPRM:

120488668(smdt1b)

RKG:	130070059(smdt1b)

MAMB:

125248539 125271792(smdt1b)

CIDE:

127514484

CERY:

137008133 137031749(smdt1b)

MASI:

127443607 127445590 127450862

TROS:

130552370(smdt1b)

TDW:	130433334(smdt1b)

MANU:

129436878(smdt1a) 129443981(smdt1b)

PDAB:

135768439 135785690(smdt1b)

IPU:	108272514(smdt1b)

IFU:	128616025(smdt1b)

PHYP:

113537532(smdt1)

SMEO:

124378601(smdt1b) 124382054

TFD:	113661806 113663575(smdt1b)

TVC:	132839293(smdt1b) 132842504

CGAR:

128506197(smdt1b) 128516015

NGRA:

132870518(smdt1b)

TRN:	134309270 134328621(smdt1b)

AMEX:

103023443(smdt1b) 103036919

CMAO:

118800348 118800621 118805880

EEE:	113586146(smdt1) 113591348

CHAR:

105907626(smdt1b)

SPIL:

134095442(smdt1b)

TRU:	101077897 115249793(smdt1)

TFS:	130514508 130527185

TNG:	GSTEN00020486G001

LCO:	104926652 104938955(smdt1)

NCC:	104964052(smdt1)

TBEN:

117482329(smdt1b)

CGOB:

115015871(smdt1)

PGEO:

117446102

GACU:

117537944(smdt1b)

EMAC:

134865038(smdt1b)

ELY:	117254669(smdt1b)

EFO:	125886407(smdt1b)

PLEP:

121942235(smdt1b)

SLUC:

116040524(smdt1b)

ECRA:

117960680(smdt1b)

ESP:	116701199(smdt1)

PFLV:

114569244(smdt1)

GAT:	120825535(smdt1b)

PPUG:

119217482(smdt1b)

AFB:	129096129(smdt1b)

CLUM:

117730124(smdt1b)

PSWI:

130190806(smdt1b)

CANA:

137799627(smdt1b)

CVE:	137885367(smdt1b)

MSAM:

119884285 119899177(smdt1b)

SCHU:

122868631 122872945(smdt1b)

CUD:	121503705 121508628(smdt1b)

SPUL:

138595399(smdt1b) 138604489

LMIX:

132954619 132991891(smdt1b)

ALAT:

119014278 119021516(smdt1b)

ASTR:

137600642 137609956

MZE:	101478003 101478718(smdt1)

ONL:	100695644(smdt1) 100698144

OAU:	116311541 116321387(smdt1b)

OLA:	101156580(smdt1) 110014938

OML:	112146929 112156899

CSAI:

133430568(smdt1b)

XMA:	102218568(smdt1) 102220931

XCO:	114145452 114159811(smdt1)

XHE:	116719999 116736161(smdt1)

PRET:

103468189 103468431 103468524

PFOR:

103137708 103143637(smdt1)

PLAI:

106941868(smdt1) 106960370

PMEI:

106915495(smdt1) 106920765

GAF:	122822152 122829460

PPRL:

129363421(smdt1b)

CVG:	107088411(smdt1)

CTUL:

119775679 119776781

GMU:	124862817 124863783 124869203(smdt1b)

NFU:	107382313(smdt1)

KMR:	108236165 108244363(smdt1b)

ALIM:

106536775(smdt1)

NWH:	119422133 119430449

AOCE:

111570171(smdt1b) 111583840

EJA:	138198211 138209398

BFRE:

138620272(smdt1b) 138622465

MCEP:

124998231(smdt1b)

CSEM:

103383985 103393368(smdt1)

POV:	109644247 109644402 109645719

SSEN:

122770805(smdt1b) 122785791

SSOE:

131466385(smdt1b) 131475394

HHIP:

117766295 117767038(smdt1b)

HSP:	118100786(smdt1b) 118123190

PPLT:

128437273(smdt1b) 128458777

SMAU:

118312660(smdt1b)

LCF:	108875911(smdt1b) 108877656

SDU:	111231508 111238094(smdt1)

SLAL:

111664489 111673799(smdt1)

XGL:	120787420 120800422(smdt1b)

HCQ:	109511244(smdt1)

SSCV:

125969239(smdt1b)

SBIA:

133505734(smdt1b) 133515064

PEE:	133404556(smdt1b) 133415101

PTAO:

133477104(smdt1b)

BPEC:

110162272(smdt1) 110172596

ENY:	140358694(smdt1a) 140378070(smdt1b)

MALB:

109958449 109974621(smdt1)

BSPL:

114860327 114863424(smdt1b)

SJO:	128379133(smdt1b)

SSCO:

133992720(smdt1b)

GMH:	115541113(smdt1)

SASA:

106607110(smdt1)

OGO:	124016050(smdt1b)

OKE:	118364789 127914503 127932328

OMM:	135524772(smdt1b) 135536175

OCLA:

139370259 139423785

SNH:	120034196(smdt1b)

CCLU:

121569005(smdt1b)

ELS:	114840200(smdt1)

OEP:	134014550(smdt1b)

SFM:	108926050(smdt1)

PKI:	111845263 111853217

AANG:

118219441(smdt1b)

AROT:

135243645 135248873

CCOG:

133122690(smdt1b)

LOC:	102689073(smdt1)

PSPA:

121306195(smdt1b)

PSEX:

120537042(smdt1b)

CMK:	103172986(smdt1b)

RTP:	109912739(smdt1b)

CPLA:

122542329(smdt1b)

LERI:

129713768(smdt1b)

PMRN:

116951456(SMDT1)

LRJ:	133340984 133341008

BFO:

BBEL:

AAMU:

AFIL:

DME:	Dmel_CG17680(EMRE)

DER:	6542756 6547008

DSE:

6609741

DSI:	Dsimw501_GD23444(Dsim_GD23444) Dsimw501_GD25414(Dsim_GD25414)

DYA:	Dyak_GE13934 Dyak_GE14275

DAN:

6495132

DSR:	110176350 110186059

DPO:	4804152 6903524

DPE:

6589906

DMN:	108158554 108164282 117191051

DWI:

6639904

DGR:

6560200

DMO:	Dmoj_GI20953 Dmoj_GI26678

DNV:

108652991

DHE:

111595540

DVI:	6625782(EMRE)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119680713 119680715

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135960120(EMRE)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ001280

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

PBAR:

VEM:

COBS:

139106455(Emre)

TLN:	139821006(Emre)

HST:

DQU:

CFO:

FEX:

PMEC:

138944818(Emre)

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

AGIF:

CINS:

CCIN:

DSM:

NPT:	124220373(EMRE)

NFB:

NLO:

NVG:

AROA:

TMOL:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

DVV:

NVL:

APLN:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207728

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

BPHI:

137933579(EMRE)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:	126901357 126909902

BTAB:

109044003

DCI:

103519805

CLEC:

112127761

HHAL:

106688329(EMRE)

MQU:

128982732

PHU:	Phum_PHUM355130

IEL:

HAMR:

FCD:

PCHN:

PMOO:

CQD:	128686231(EMRE)

PTRU:

123516123

PPOI:

119113883 119113995 119114220

VDE:

VJA:

DFR:

ABRU:

CEL:	CELE_F20D1.10(emre-1)

CBR:	CBG_07651(Cbr-tag-299)

CRQ:	GCK72_025602 GCK72_025607

NAI:	NECAME_00139

LOA:	LOAG_02760

HRO:	HELRODRAFT_96981

LGI:	LOTGIDRAFT_149539 LOTGIDRAFT_185103

PMAX:

117329757

SMM:	Smp_032790 Smp_152270

OVI:	T265_14890

HSY:

VRI:

CABA:

MALA:

THEU:

Reference

PMID:24231807

Authors

Sancak Y, Markhard AL, Kitami T, Kovacs-Bogdan E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK

Title

EMRE is an essential component of the mitochondrial calcium uniporter complex.

Journal

Science 342:1379-82 (2013)
DOI:10.1126/science.1242993

Sequence

[hsa:91689]

LinkDB

DBGET integrated database retrieval system