KEGG ORTHOLOGY: K22874

ORTHOLOGY: K22874

Entry

K22874                      KO

Symbol

pvcB

Name

L-tyrosine isonitrile desaturase/decarboxylase [EC:1.14.20.9 1.14.20.10]

Pathway

map00997

Biosynthesis of various other secondary metabolites

Reaction

R12076

(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate,2-oxoglutarate:oxygen oxidoreductase (decarboxylating)

R12081

(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate,2-oxoglutarate:oxygen oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various other secondary metabolites
    K22874  pvcB; L-tyrosine isonitrile desaturase/decarboxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.20  With 2-oxoglutarate as one donor, and the other dehydrogenated
    1.14.20.9  L-tyrosine isonitrile desaturase
     K22874  pvcB; L-tyrosine isonitrile desaturase/decarboxylase
    1.14.20.10  L-tyrosine isonitrile desaturase/decarboxylase
     K22874  pvcB; L-tyrosine isonitrile desaturase/decarboxylase

Other DBs

COG:

COG2175

Genes

SMAR:

SM39_0024(pvcB)

SMAC:

SMDB11_0022(pvcB)

SMW:	SMWW4_v1c06960

SPE:

Spro_0704

SRR:	SerAS9_0644

SRL:	SOD_c05760

SRY:	M621_03040

SPLY:

Q5A_003040

SRS:	SerAS12_0644

SRA:	SerAS13_0644

SLQ:	M495_02880

SERF:

L085_00780

SQU:	E4343_13095

SFJ:	SAMEA4384070_0732

SSUR:

SURI:

SENP:

SNEM:

SNEV:

SGRI:

FSM:	CCS41_08785

ECA:	ECA3380(pvcB)

PATR:

EV46_16840

PATO:

GZ59_34170(pvcB)

PCT:	PC1_2908 PC1_3224

PCC:	PCC21_029460

PCV:	BCS7_14800 BCS7_16165

PWA:	Pecwa_1104

PPAR:

A8F97_13425

PEC:

W5S_0996

PWS:	A7983_12895

PPOA:

BJK05_09650

PBRA:

B5S52_07100

PPUJ:

E2566_16435

PARI:

I2D83_05690 I2D83_07055

PAQU:

DMB82_0006950

PVZ:	OA04_31220

PPAV:

LOZ86_14585 LOZ86_16795

PQU:	IG609_006085

PPOO:

PCAC:

PACB:

PCOA:

EAM:	EAMY_1787(pvcB)

EAY:	EAM_1750(pvcB)

ERJ:	EJP617_29220(pvcB)

PLU:

plu2817

PLUM:

A4R40_14045

PAY:	PAU_01720(pvcB)

PTT:	VY86_17220

PAKH:

PLUI:

XBO:

XBV:

XNE:

XNM:	XNC2_1198(isnB)

XDO:

XDD1_2892

XPO:

XPG1_0844

XHO:	A9255_00175

XBU:	HGO23_14995

XGR:	QL128_05130

PMAG:

JI723_04270

LEZ:

GLE_4812

LYA:	RDV84_09230

VCH:

VC_1944

VCF:	IR04_14875

VCS:

MS6_1705

VCE:	Vch1786_I1437(pvcB)

VCQ:	EN18_12835

VCJ:	VCD_002418

VCI:

O3Y_09405

VCO:	VC0395_A1534(pvcB)

VCR:	VC395_2059(pvcB)

VCM:	VCM66_1868(pvcB)

VCL:	VCLMA_A1689

VCX:	VAA049_932

VCZ:	VAB027_2586

VNI:	VIBNI_A3570(pvcB)

VAN:

VAA_02643

LAG:	N175_02885

VAU:	VANGNB10_cI2373c(pvcB)

VQI:	CCZ37_11640

VPL:	SA104470976_01651(pvcB)

PAE:	PA2255(pvcB)

PAEV:

N297_2328(pvcB)

PAEI:

N296_2328(pvcB)

PAU:	PA14_35420(pvcB)

PAP:	PSPA7_2986(pvcB)

PAG:	PLES_30491(pvcB)

PAF:	PAM18_2785(pvcB)

PNC:	NCGM2_3265(pvcB)

PAEB:

NCGM1900_4275(pvcB)

PDK:	PADK2_14000

PSG:	G655_13765

PRP:	M062_11795

PAEP:

PAER:

PAEM:

PAEL:

PAES:

PAEU:

BN889_02461(pvcB)

PAEG:

AI22_19510

PAEC:

M802_2325(pvcB)

PAEO:

M801_2327(pvcB)

SECH:

B18_23350

PPAA:

B7D75_13685

PLQ:	AA042_05065

PTRT:

HU722_0010625

ACD:	AOLE_01055

SPSH:

FM037_15215

PPIS:

B1L02_15130

PSEN:

PNC201_02370(carC)

MICZ:

GL2_40870

ALG:	AQULUS_02970(ptlD)

ASIP:

AQUSIP_24820(sdpA)

LPN:

lpg0175

LPH:	LPV_0258(pvcB)

LPO:	LPO_0206(pvcB)

LPU:	LPE509_03055

LPM:	LP6_0179(pvcB)

LPF:

lpl0237

LPP:

lpp0237

LPC:	LPC_0257(pvcB)

LPA:

lpa_00342

LPE:

lp12_0177

LLO:

LLO_2213

LSH:	CAB17_16390

LLG:	44548918_00375

LIB:	E4T55_11460

LCJ:	NCTC11976_00381

LSS:	NCTC12082_02497

THIP:

N838_14005

TOL:

TOL_3183

TOR:	R615_14965

AHA:

AHA_3281

AHY:	AHML_17545

AHD:	AI20_02950

AHR:	V428_18200

AHP:	V429_18235

AHJ:	V469_05060

AHH:	RY45_16925

AHI:	VU14_05265

AAJ:	BOQ57_16800

ASA:	ASA_1025(pvcB)

AEO:	O23A_p0208

ADH:	CK627_09305

AEJ:	E5E97_22350

ABES:

IU367_04955

BMA:	BMAA1923(pvcB)

BMV:	BMASAVP1_0938(pvcB)

BML:	BMA10229_1223(pvcB)

BMN:	BMA10247_A2200(pvcB)

BMAL:

DM55_3864(pvcB)

BMAE:

DM78_4783(pvcB)

BMAQ:

DM76_4561(pvcB)

BMAI:

DM57_06430

BMAF:

DM51_3611

BMAZ:

BM44_3823(pvcB)

BMAB:

BM45_4600

BPS:

BPSS0161

BPM:	BURPS1710b_A1680(pvcB)

BPL:	BURPS1106A_A0229(pvcB)

BPD:	BURPS668_A0319(pvcB)

BPSE:

BDL_6052(pvcB)

BPSM:

BBQ_6053(pvcB)

BPSU:

BBN_3541(pvcB)

BPSD:

BBX_5222(pvcB)

BPZ:	BP1026B_II0181

BPQ:	BPC006_II0218

BPK:	BBK_5353(pvcB)

BPSH:

DR55_5201(pvcB)

BPSA:

BBU_3411(pvcB)

BPSO:

X996_4969(pvcB)

BUT:

X994_4518

BTE:	BTH_II0230(pvcB)

BTQ:	BTQ_3525(pvcB)

BTJ:	BTJ_4562(pvcB)

BTZ:	BTL_5349(pvcB)

BTV:	BTHA_4852(pvcB)

BTHE:

BTN_5020(pvcB)

BTHM:

BTRA_5288(pvcB)

BTHA:

DR62_5150

BTHL:

BG87_5355

BOK:	DM82_3790(pvcB)

BOC:

BG90_4253

BUU:	WS70_27860

BSAV:

BUB:

BSTG:

PBRY:

BBA:	Bd1455(pvcB)

BBAT:

Bdt_1441(pvcB)

BBAC:

EP01_03535

BDQ:	CIK05_01010

PIJ:	QEJ31_14490

MMAU:

NCTC10168_00532

NBR:	O3I_007380

NIE:	KV110_36470

NGP:	LTT66_00580

NSPU:

SGRF:

SALS:

STRE:

SRN:	A4G23_02273(tfdA)

SCAD:

DN051_33295

SNR:	SNOUR_09500

SRK:	FGW37_29470

SBY:	H7H31_08600 H7H31_12645

SRIM:

CP984_10750

SBAT:

G4Z16_03990

SFB:	CP974_12515

SAOV:

SYUN:

SCHG:

STRZ:

FRA:	Francci3_2755

AAB:	A4R43_21560

KAL:

KALB_6298

CROS:

N8J89_22510

UAM:	UABAM_02082

CHF:	KTO58_07945

HSW:	Hsw_PA0222

FSD:	LXD69_13600

» show all

Reference

PMID:18824174

Authors

Drake EJ, Gulick AM

Title

Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin.

Journal

J Mol Biol 384:193-205 (2008)
DOI:10.1016/j.jmb.2008.09.027

Sequence

[pae:PA2255]

Reference

PMID:22711807

Authors

Crawford JM, Portmann C, Zhang X, Roeffaers MB, Clardy J

Title

Small molecule perimeter defense in entomopathogenic bacteria.

Journal

Proc Natl Acad Sci U S A 109:10821-6 (2012)
DOI:10.1073/pnas.1201160109

Sequence

[xne:XNC1_1222] [plu:plu2817]

Reference

PMID:25866990

Authors

Zhu J, Lippa GM, Gulick AM, Tipton PA

Title

Examining Reaction Specificity in PvcB, a Source of Diversity in Isonitrile-Containing Natural Products.

Journal

Biochemistry 54:2659-69 (2015)
DOI:10.1021/acs.biochem.5b00255

Sequence

[pae:PA2255] [xne:XNC1_1222]

LinkDB

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