KEGG   ORTHOLOGY: K23524
Entry
K23524            Tight     KO                                     
Symbol
UGTPg100
Name
ginsenoside 6-O-glucosyltransferase [EC:2.4.1.367]
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01110  Biosynthesis of secondary metabolites
Reaction
R12387  UDP-alpha-D-glucose:ginsenoside F1 6-O-glucosyltransferase
R12388  UDP-alpha-D-glucose:protopanaxatriol 6-O-glucosyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various plant secondary metabolites
    K23524  UGTPg100; ginsenoside 6-O-glucosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K23524  UGTPg100; ginsenoside 6-O-glucosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.367  ginsenoside 6-O-glucosyltransferase
     K23524  UGTPg100; ginsenoside 6-O-glucosyltransferase
Glycosyltransferases [BR:ko01003]
 Others
  Hydrophobic molecule
   K23524  UGTPg100; ginsenoside 6-O-glucosyltransferase
Other DBs
CAZy: GT1
Genes
AG: AKQ76388(UGTPg100)
Reference
PMID:26032089
  Authors
Wei W, Wang P, Wei Y, Liu Q, Yang C, Zhao G, Yue J, Yan X, Zhou Z
  Title
Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts.
  Journal
Mol Plant 8:1412-24 (2015)
DOI:10.1016/j.molp.2015.05.010
  Sequence
[ag:AKQ76388]
LinkDB

KEGG   ENZYME: 2.4.1.367
Entry
EC 2.4.1.367                Enzyme                                 
Name
ginsenoside 6-O-glucosyltransferase;
UGTPg100 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:ginsenoside 6-O-glucosyltransferase
Reaction(IUBMB)
(1) UDP-alpha-D-glucose + protopanaxatriol = UDP + ginsenoside Rh1 [RN:R12388];
(2) UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1 [RN:R12387]
Reaction(KEGG)
R12387 R12388
Substrate
UDP-alpha-D-glucose [CPD:C00029];
protopanaxatriol [CPD:C20716];
ginsenoside F1 [CPD:C20780]
Product
UDP [CPD:C00015];
ginsenoside Rh1 [CPD:C22129];
(20S)-ginsenoside Rg1 [CPD:C08946]
Comment
The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of protopanaxatriol and ginsenoside F1.
History
EC 2.4.1.367 created 2019
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01110  Biosynthesis of secondary metabolites
Orthology
K23524  ginsenoside 6-O-glucosyltransferase
Reference
1  [PMID:26032089]
  Authors
Wei W, Wang P, Wei Y, Liu Q, Yang C, Zhao G, Yue J, Yan X, Zhou Z
  Title
Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts.
  Journal
Mol Plant 8:1412-24 (2015)
DOI:10.1016/j.molp.2015.05.010
  Sequence
[ag:AKQ76388]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.367
IUBMB Enzyme Nomenclature: 2.4.1.367
ExPASy - ENZYME nomenclature database: 2.4.1.367
BRENDA, the Enzyme Database: 2.4.1.367
LinkDB

KEGG   REACTION: R12388
Entry
R12388                      Reaction                               
Name
UDP-alpha-D-glucose:protopanaxatriol 6-O-glucosyltransferase
Definition
UDP-glucose + Protopanaxatriol <=> UDP + Ginsenoside Rh1
Equation
C00029 + C20716 <=> C00015 + C22129
Reaction class
RC00049  C20716_C22129
Enzyme
2.4.1.367
Pathway
rn00999  Biosynthesis of various plant secondary metabolites
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.367
     R12388  UDP-glucose + Protopanaxatriol <=> UDP + Ginsenoside Rh1
Glycosyltransferase reactions [br08203.html]
 Glucosyltransferase reactions
  R12388
Orthology
K23524  ginsenoside 6-O-glucosyltransferase [EC:2.4.1.367]
LinkDB

DBGET integrated database retrieval system