KEGG   ORTHOLOGY: K23665
Entry
K23665                      KO                                     
Symbol
FMQA
Name
fumiquinazoline F synthetase [EC:6.3.2.-]
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
Reaction
R12417  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various other secondary metabolites
    K23665  FMQA; fumiquinazoline F synthetase
Other DBs
COG: COG1020 COG0318
Genes
AFM: AFUA_6G12080
ACT: ACLA_017890
NFI: NFIA_057960
ACHE: ACHE_60930S
APUU: APUU_81087S
PDP: PDIP_40000
Reference
PMID:20225828
  Authors
Ames BD, Walsh CT
  Title
Anthranilate-activating modules from fungal nonribosomal peptide assembly lines.
  Journal
Biochemistry 49:3351-65 (2010)
DOI:10.1021/bi100198y
  Sequence
[afm:AFUA_6G12080]
Reference
PMID:24612080
  Authors
Lim FY, Ames B, Walsh CT, Keller NP
  Title
Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.
  Journal
Cell Microbiol 16:1267-83 (2014)
DOI:10.1111/cmi.12284
  Sequence
[afm:AFUA_6G12080]
LinkDB

KEGG   REACTION: R12417
Entry
R12417                      Reaction                               
Definition
Anthranilate + L-Tryptophan + L-Alanine + 3 ATP <=> Fumiquinazoline F + 3 AMP + 3 Diphosphate + H2O
Equation
C00108 + C00078 + C00041 + 3 C00002 <=> C22145 + 3 C00020 + 3 C00013 + C00001
Comment
fumiquinazoline F synthetase
Enzyme
6.3.2.-
Pathway
rn00997  Biosynthesis of various other secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.-
     R12417  Anthranilate + L-Tryptophan + L-Alanine + 3 ATP <=> Fumiquinazoline F + 3 AMP + 3 Diphosphate + H2O
Orthology
K23665  fumiquinazoline F synthetase [EC:6.3.2.-]
LinkDB

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