KEGG   ORTHOLOGY: K23666
Entry
K23666                      KO                                     
Symbol
FMQB
Name
fumiquinazoline F monooxygenase [EC:1.14.14.-]
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
Reaction
R12418  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various other secondary metabolites
    K23666  FMQB; fumiquinazoline F monooxygenase
Other DBs
COG: COG0654
Genes
AFM: AFUA_6G12060
ACT: ACLA_017920
NFI: NFIA_057970
PDP: PDIP_39990
Reference
PMID:20804163
  Authors
Ames BD, Liu X, Walsh CT
  Title
Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis.
  Journal
Biochemistry 49:8564-76 (2010)
DOI:10.1021/bi1012029
  Sequence
[afm:AFUA_6G12060]
Reference
PMID:24612080
  Authors
Lim FY, Ames B, Walsh CT, Keller NP
  Title
Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.
  Journal
Cell Microbiol 16:1267-83 (2014)
DOI:10.1111/cmi.12284
  Sequence
[afm:AFUA_6G12060]
LinkDB

KEGG   REACTION: R12418
Entry
R12418                      Reaction                               
Definition
Fumiquinazoline F + 3 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> Fumiquinazoline F-indoline-2',3'-diol + 3 [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C22145 + 3 C03024 + 2 C00007 <=> C22146 + 3 C03161 + 2 C00001
Comment
fumiquinazoline F monooxygenase
Enzyme
1.14.14.-
Pathway
rn00997  Biosynthesis of various other secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-
     R12418  Fumiquinazoline F + 3 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> Fumiquinazoline F-indoline-2',3'-diol + 3 [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Orthology
K23666  fumiquinazoline F monooxygenase [EC:1.14.14.-]
LinkDB

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