KEGG   ORTHOLOGY: K23667
Entry
K23667                      KO                                     
Symbol
FMQC
Name
fumiquinazoline A synthase [EC:6.3.2.-]
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
Reaction
R12419  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various other secondary metabolites
    K23667  FMQC; fumiquinazoline A synthase
Other DBs
COG: COG1020
Genes
AFM: AFUA_6G12050
ACT: ACLA_017900
NFI: NFIA_057990
PDP: PDIP_39920
Reference
PMID:20804163
  Authors
Ames BD, Liu X, Walsh CT
  Title
Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis.
  Journal
Biochemistry 49:8564-76 (2010)
DOI:10.1021/bi1012029
  Sequence
[afm:AFUA_6G12050]
Reference
PMID:24612080
  Authors
Lim FY, Ames B, Walsh CT, Keller NP
  Title
Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.
  Journal
Cell Microbiol 16:1267-83 (2014)
DOI:10.1111/cmi.12284
  Sequence
[afm:AFUA_6G12050]
LinkDB

KEGG   REACTION: R12419
Entry
R12419                      Reaction                               
Definition
Fumiquinazoline F-indoline-2',3'-diol + L-Alanine + ATP <=> Fumiquinazoline A + AMP + Diphosphate + H2O
Equation
C22146 + C00041 + C00002 <=> C22147 + C00020 + C00013 + C00001
Comment
fumiquinazoline A synthetase
Enzyme
6.3.2.-
Pathway
rn00997  Biosynthesis of various other secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.-
     R12419  Fumiquinazoline F-indoline-2',3'-diol + L-Alanine + ATP <=> Fumiquinazoline A + AMP + Diphosphate + H2O
Orthology
K23667  fumiquinazoline A synthase [EC:6.3.2.-]
LinkDB

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