KEGG ORTHOLOGY: K23701

ORTHOLOGY: K23701

Entry

K23701                      KO

Symbol

SH2D5

Name

SH2 domain-containing protein 5

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K23701  SH2D5; SH2 domain-containing protein 5
Domain-containing proteins not elsewhere classified [BR:ko04990]
Src homology (SH) domain-containing proteins
  Other SH2 and SH3-containing proteins
   K23701  SH2D5; SH2 domain-containing protein 5

Genes

HSA:	400745(SH2D5)

PTR:	749040(SH2D5)

PPS:	100971210(SH2D5)

GGO:	101128512(SH2D5)

PON:	100173416(SH2D5)

PPYG:

129044747(SH2D5)

NLE:	100600852(SH2D5)

HMH:	116813032(SH2D5)

SSYN:

129471924(SH2D5)

MCC:	717509(SH2D5)

MCF:	102122588(SH2D5)

MTHB:

126955305

MNI:	105483082(SH2D5)

CSAB:

103225447(SH2D5)

CATY:

105595038(SH2D5)

PANU:

101025199(SH2D5)

TGE:	112614003(SH2D5)

MLEU:

105546840(SH2D5)

RRO:	104663207(SH2D5)

RBB:	108515340(SH2D5) 108523665

TFN:	117093183(SH2D5)

PTEH:

111547730(SH2D5)

CANG:

105505991(SH2D5)

CJC:	100398731(SH2D5)

SBQ:	101028533(SH2D5)

CIMI:

108287884(SH2D5)

ANAN:

105708517(SH2D5)

CSYR:

103254794(SH2D5)

MMUR:

105873629 105883987(SH2D5)

LCAT:

123635886(SH2D5)

ERUF:

138389211(SH2D5)

PCOQ:

105822313(SH2D5)

OGA:	100954562(SH2D5)

MMU:	230863(Sh2d5)

MCAL:

110293528(Sh2d5)

MPAH:

110323646(Sh2d5)

RNO:	366489(Sh2d5)

MCOC:

116096897(Sh2d5)

ANU:	117708646(Sh2d5)

ASYL:

127680146(Sh2d5)

MUN:	110544998(Sh2d5)

CGE:	100765078(Sh2d5)

MAUA:

101828931(Sh2d5)

PROB:

127213320(Sh2d5)

PLEU:

114697196(Sh2d5)

PMAV:

102903819(Sh2d5)

MORG:

121447899(Sh2d5)

MFOT:

126506758

AAMP:

119816060(Sh2d5)

CNL:	130884207(Sh2d5)

NGI:	103738568(Sh2d5)

HGL:	101717765(Sh2d5)

CPOC:

100719699(Sh2d5)

CCAN:

109689696(Sh2d5)

DORD:

105998898(Sh2d5)

DSP:	122115314(Sh2d5)

DMER:

138838000(Sh2d5)

PLOP:

125354238(Sh2d5)

NCAR:

124994481

MMMA:

107142165(Sh2d5)

ITI:	101955731(Sh2d5)

OCU:	100350420 127493634

OPI:	101535133 101536393

OCZ:	121161395(SH2D5) 121167577

TUP:	102495671(SH2D5)

GVR:	103606052(SH2D5)

CFA:	100686893(SH2D5)

CLUD:

112660220(SH2D5)

VVP:	112912779 112929831(SH2D5)

VLG:	121497469(SH2D5)

NPO:	129513833(SH2D5)

AML:	100464609(SH2D5)

UMR:

103666802

UAH:	113268558(SH2D5)

UAR:	123782294(SH2D5)

ELK:

111154838

LLV:

125099028

MPUF:

101671771(SH2D5)

MNP:	132001000(SH2D5)

MLK:	131810060(SH2D5)

NVS:	122899534(SH2D5)

ORO:	101382573(SH2D5)

EJU:	114199034(SH2D5)

ZCA:	113935634(SH2D5)

MLX:	118020311(SH2D5)

MANO:

123858444(SH2D5)

NSU:	110574737(SH2D5)

LWW:	102737590(SH2D5)

FCA:	101093284(SH2D5)

PYU:	121022419(SH2D5)

PCOO:

112848522(SH2D5)

PBG:	122480043(SH2D5)

PVIV:

125173159(SH2D5)

LRUF:

124514515

LGF:	123597325(SH2D5)

AJU:

106988013

PTG:	102955525(SH2D5)

PPAD:

109274252(SH2D5)

PUC:

125913012

PLEZ:

122228090(SH2D5)

HHV:	120229813(SH2D5)

CCRU:

144241205(SH2D5)

BTA:	789769(SH2D5)

BOM:	102273655(SH2D5)

BIU:	109576166(SH2D5)

BBUB:

102398399(SH2D5)

BKE:	129647955(SH2D5)

BBIS:

104981074(SH2D5)

CHX:	102190004(SH2D5)

OAS:	101105890(SH2D5)

BTAX:

128071108(SH2D5)

CSUM:

138077001(SH2D5)

ODA:	120855005(SH2D5)

CCAD:

122426801(SH2D5)

MREE:

136163071(SH2D5)

OVR:	110149579(SH2D5)

MBEZ:

129537908(SH2D5)

SSC:	100515781(SH2D5)

CFR:	102510706(SH2D5)

CBAI:

105070888(SH2D5)

CDK:	105088858(SH2D5)

VPC:	102527252(SH2D5)

BACU:

103004496(SH2D5)

BMUS:

118879798(SH2D5)

LVE:	103068720(SH2D5)

OOR:	101288146(SH2D5)

LALB:

132516347(SH2D5)

GMF:	115863320(SH2D5)

DDP:	132413777(SH2D5)

DLE:	111163397(SH2D5)

PCAD:

102994945(SH2D5)

PSIU:

116739612(SH2D5)

PPHC:

136135617(SH2D5)

NASI:

112402656(SH2D5)

ECB:	100071771(SH2D5)

EPZ:	103565499(SH2D5)

EAI:	106840018(SH2D5)

MYB:	102263670(SH2D5)

MYD:	102764228(SH2D5)

MMYO:

118677743(SH2D5)

MLF:	102434520(SH2D5)

MDT:	132229543(SH2D5)

MYUM:

139001655(SH2D5)

PKL:	118722713(SH2D5)

EFUS:

103291979(SH2D5)

MNA:	107538373(SH2D5)

DRO:	112298979(SH2D5)

SHON:

118977796(SH2D5)

AJM:	119045378(SH2D5)

PDIC:

114497636(SH2D5)

PHAS:

123832018(SH2D5)

MMF:	118627089(SH2D5)

PPAM:

129068966(SH2D5)

HAI:	109395553(SH2D5)

RFQ:	117026552(SH2D5)

PALE:

102891981(SH2D5)

PGIG:

120596239(SH2D5)

PVP:	105290424(SH2D5)

RAY:	107513045(SH2D5)

MJV:	108398644(SH2D5)

TOD:	119235798(SH2D5)

SARA:

101538168(SH2D5)

SFUM:

130031828(SH2D5)

SETR:

126006573(SH2D5)

LAV:	100671192(SH2D5)

TMU:

101343777

ETF:	101649602(SH2D5)

DNM:	101430490(SH2D5)

MDO:	100026973(SH2D5)

GAS:	123241003(SH2D5)

SHR:	100928114(SH2D5)

AFZ:

127555759

PCW:	110198763(SH2D5)

TVP:	118835535(SH2D5) 118849789

PBRV:

138154628(SH2D5)

MLAO:

141509035(SH2D5)

OAA:	114811989(SH2D5)

GGA:	769539(SH2D5)

PCOC:

116238357(SH2D5)

MGP:	100550311(SH2D5)

CJO:	107323544(SH2D5)

TPAI:

128084963(SH2D5)

LMUT:

125703222(SH2D5)

NMEL:

110386954(SH2D5)

ACYG:

106048617(SH2D5)

CATA:

118258825(SH2D5)

AFUL:

116497727(SH2D5)

TGU:	100229220(SH2D5)

LSR:	110474462(SH2D5)

SCAN:

103820962

PMOA:

120496736(SH2D5)

OTC:	121343913(SH2D5)

PRUF:

121351334(SH2D5)

ATRC:

139600737(SH2D5)

GFR:	102034642(SH2D5)

FAB:	101808438(SH2D5)

OMA:	130261715(SH2D5)

PHI:	102109330(SH2D5)

PMAJ:

107213553(SH2D5)

CCAE:

111945338(SH2D5)

CCW:	104698592(SH2D5)

CBRC:

103614551(SH2D5)

ACOE:

138121323(SH2D5)

ZAB:	102067396(SH2D5)

ZLE:	135456757(SH2D5)

SVG:	106860509(SH2D5)

MMEA:

130581858(SH2D5)

HRT:	120762305(SH2D5)

SATI:

136370684(SH2D5)

CCIC:

134052977(SH2D5)

FPG:	101922363(SH2D5)

FCH:	102054736(SH2D5)

SHAB:

115617447(SH2D5)

TALA:

116963311(SH2D5)

GCL:

127024800

DPUB:

104309954(SH2D5)

PPUS:

135190616(SH2D5)

EGZ:	104133196(SH2D5)

NNI:	104011245(SH2D5)

PARX:

142066569(SH2D5)

CBOR:

142092227(SH2D5)

CBOY:

140661725(SH2D5)

CLV:	102096651(SH2D5)

CUCA:

104062268(SH2D5)

CPEA:

104387077(SH2D5)

CRID:

134524167(SH2D5)

AROW:

112966857(SH2D5)

NPD:	112957426(SH2D5)

DNE:	112992564(SH2D5)

ASN:	102378211(SH2D5)

AMJ:	102564036(SH2D5)

CPOO:

109314311(SH2D5)

GGN:	109293858(SH2D5)

ASAO:

132764789(SH2D5)

PVT:	110073179(SH2D5)

SUND:

121937242(SH2D5)

PBI:	112541725(SH2D5)

PMUR:

107297524(SH2D5)

CTIG:

120319164(SH2D5)

TSR:	106551668(SH2D5)

PGUT:

117656558(SH2D5)

PCAE:

139326047(SH2D5)

APRI:

131187235(SH2D5)

PTEX:

113446300(SH2D5)

NSS:	113423157(SH2D5)

VKO:	123018830(SH2D5)

PMUA:

114602791(SH2D5)

PRAF:

128419906(SH2D5)

ZVI:	118087404(SH2D5)

HCG:	128338553(SH2D5)

GJA:	107111594(SH2D5)

STOW:

125445697(SH2D5)

EMC:	129344671(SH2D5)

XLA:

108705071

XTR:	116412088(sh2d5)

NPR:	108803364(SH2D5)

RTEM:

120915928(SH2D5)

ACAT:

141109772 141109773

BBUF:

120986824(SH2D5)

BGAR:

122927035(SH2D5)

DTC:	141084860(SH2D5)

PWL:	138300541(SH2D5)

MUO:	115456818(SH2D5)

DRE:	541529(sh2d5)

SRX:	107743262 107751244

SANH:

107694878 107697739

SGH:

107580363

CCAR:

109099045 109099050(sh2d5)

CAUA:

113055490 113055538 113110838

CGIB:

127968515 128022106

PTET:

122354675(sh2d5)

LROH:

127172753(sh2d5)

GRF:	141294168(sh2d5)

OMC:	131549790(sh2d5)

PPRM:

120480484(sh2d5)

RKG:	130106404(sh2d5)

MAMB:

125256911(sh2d5)

CIDE:

127522279

CERY:

137020984(sh2d5)

MASI:

127426093 127427896

TROS:

130571273(sh2d5)

TDW:	130410283(sh2d5)

MANU:

129427975(sh2d5)

PDAB:

135718696(sh2d5)

IPU:

108255185

IFU:	128625349(sh2d5)

PHYP:

113537870(sh2d5)

TFD:	113647859(sh2d5)

TVC:	132838350(sh2d5)

CGAR:

128511498(sh2d5)

NGRA:

132873965(sh2d5)

TRN:	134301508(sh2d5)

AMEX:

103038984(sh2d5)

CMAO:

118799639(sh2d5)

EEE:	113586221(sh2d5)

CHAR:

105900499(sh2d5)

SPIL:

134092919(sh2d5)

ASAD:

121706403(sh2d5)

TRU:	101062931(sh2d5)

TFS:	130524847(sh2d5)

TNG:	GSTEN00004681G001

LCO:	104922732(sh2d5)

NCC:	104942083(sh2d5)

TBEN:

117489774(sh2d5)

CGOB:

115008366(sh2d5)

PGEO:

117446992 117447340

GACU:

117536204(sh2d5)

EMAC:

134882821(sh2d5)

ELY:	117256326(sh2d5)

EFO:	125893939(sh2d5)

PLEP:

121961486(sh2d5)

SLUC:

116051505(sh2d5)

ECRA:

117943622(sh2d5)

ESP:	116688295(sh2d5)

PFLV:

114554414(sh2d5)

GAT:	120835700(sh2d5)

PPUG:

119229426(sh2d5)

AFB:	129105407(sh2d5)

CLUM:

117730798(sh2d5)

PSWI:

130208970(sh2d5)

CANA:

137798867(sh2d5)

CVE:	137873994(sh2d5)

MSAM:

119885689(sh2d5)

SCHU:

122862623(sh2d5)

EARM:

139282887(sh2d5)

CUD:	121503871(sh2d5)

SPUL:

138606010(sh2d5)

LMIX:

132976912(sh2d5)

HTC:	141793354(sh2d5)

ALAT:

119021781(sh2d5)

ASTR:

137596026(sh2d5)

PKLU:

139211273(sh2d5)

MZE:	101467675(sh2d5)

ONL:	100703348 112846888

OAU:	116320297(sh2d5)

OLA:	101164974(sh2d5)

OML:	112145423(sh2d5)

CSAI:

133449310(sh2d5)

XMA:	102225192(sh2d5)

XCO:	114135427(sh2d5)

XHE:	116710636(sh2d5)

PRET:

103464754(sh2d5)

PFOR:

103134645(sh2d5)

PLAI:

106936333(sh2d5)

PMEI:

106918449(sh2d5)

GAF:	122834219(sh2d5)

PPRL:

129372870(sh2d5)

CVG:	107085137(sh2d5)

CTUL:

119787398(sh2d5)

GMU:	124857093(sh2d5)

NFU:	107384881(sh2d5)

KMR:	108231544(sh2d5)

ALIM:

106518332(sh2d5)

NWH:	119412202(sh2d5)

AOCE:

111565009(sh2d5)

EJA:	138198209(sh2d5)

BFRE:

138616691(sh2d5)

MCEP:

125006532(sh2d5)

CSEM:

103386462(sh2d5)

POV:	109635551(sh2d5)

SSEN:

122767634(sh2d5)

SSOE:

131461478(sh2d5)

HHIP:

117762018(sh2d5)

HSP:	118102647(sh2d5)

PPLT:

128446923(sh2d5)

SMAU:

118309489 124850056

LCF:

108902529

SDU:	111233579(sh2d5)

SLAL:

111660700(sh2d5)

XGL:	120783460(sh2d5)

HCQ:	109507355(sh2d5)

SSCV:

125977661(sh2d5)

SBIA:

133507758(sh2d5)

PEE:	133408773(sh2d5)

PTAO:

133483058(sh2d5)

BPEC:

110154622(sh2d5)

ENY:	140365651(sh2d5)

MALB:

109955079(sh2d5)

BSPL:

114855312(sh2d5)

SJO:	128356158(sh2d5)

SSCO:

133977023(sh2d5)

TTY:	137181130(sh2d5)

GMH:	115557224(sh2d5)

SASA:

106565884 106582994

STRU:

115150729 115207705

OTW:	112218651 112254468

OMY:	110494453 110527994

OGO:	124003755 124020307

ONE:	115138690 115143279

OKI:	109890198 109906870

OKE:	118388470 118400204

OMM:	135540094 135542046

OCLA:

139371174 139414296

SALP:

111967842 111969979

SNH:	120059577 120065121

SFON:

129815153 129850417

CCLU:

121575967 121577735(sh2d5)

ELS:	105017288(sh2d5)

OEP:	134018333(sh2d5)

SFM:	108918225(sh2d5)

PKI:	111852034(sh2d5)

AANG:

118211114(sh2d5)

AROT:

135237783(sh2d5)

CCOG:

133109726(sh2d5)

LOC:	102697850(sh2d5)

PSPA:

121328462 121328639

ARUT:

117425972 117432465

PSEX:

120530909(sh2d5)

LCM:	102353066(SH2D5)

CMK:	103181374(sh2d5)

RTP:	109923320(sh2d5)

CPLA:

122540192(sh2d5)

CPUN:

140487164(sh2d5)

HOC:	132833663(sh2d5)

SCAU:

119979480(sh2d5)

LERI:

129711632(sh2d5)

HAKA:

140718229(sh2d5)

BBEL:

PPOI:

BGT:

HRF:

HRJ:

OSN:

CCLM:

Reference

PMID:25331951

Authors

Gray EJ, Petsalaki E, James DA, Bagshaw RD, Stacey MM, Rocks O, Gingras AC, Pawson T

Title

Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP.

Journal

J Biol Chem 289:35397-408 (2014)
DOI:10.1074/jbc.M114.615112

Sequence

[hsa:400745]

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