KEGG ORTHOLOGY: K23756

ORTHOLOGY: K23756

Entry

K23756                      KO

Symbol

ACSM1, LAE

Name

medium-chain acyl-CoA ligase / lipoate-activating enzyme [EC:6.2.1.2]

Pathway

map00650

Butanoate metabolism

map00785

Lipoic acid metabolism

map01100

Metabolic pathways

Reaction

R01176

butanoate:CoA ligase (AMP-forming)

R07770

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
Enzymes [BR:ko01000]
6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.2  medium-chain acyl-CoA ligase
     K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
Lipid biosynthesis proteins [BR:ko01004]
Acyl-CoA ligase
  Short/medium chain acyl-CoA ligase
   K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme

Other DBs

GO:

0047760

Genes

HSA:	116285(ACSM1)

PTR:	101058263(ACSM1)

PPS:

100972336

GGO:	101153106(ACSM1)

PON:	100444065 100444423

PPYG:

129015436 129016152

HMH:	116470560(ACSM1)

MCC:	696498(ACSM1)

MCF:	102123380(ACSM1)

MTHB:

126944947

MNI:	105484990(ACSM1)

CSAB:

103229298(ACSM1)

CATY:

105586560(ACSM1)

PANU:

101018326(ACSM1)

TGE:	112614782(ACSM1)

MLEU:

105536647(ACSM1)

RRO:	104682075(ACSM1)

RBB:	108513946(ACSM1)

TFN:	117087530(ACSM1)

PTEH:

111551197(ACSM1)

CANG:

105504440(ACSM1)

CSYR:

103272478

MMUR:

105855230(ACSM1)

PCOQ:

105812926(ACSM1)

OGA:

100961636

MMU:	117147(Acsm1)

MCAL:

110297667(Acsm1)

MPAH:

110326344(Acsm1)

RNO:	361638(Acsm1)

MCOC:

116102869(Acsm1)

ANU:	117713913(Acsm1)

ASYL:

127679305(Acsm1)

MUN:	110547837(Acsm1)

CGE:

100767739

MAUA:

101829208(Acsm1)

PROB:

127228251(Acsm1)

PLEU:

114692159(Acsm1)

MORG:

121457640(Acsm1)

MFOT:

126502317

AAMP:

119825600

NGI:	103742763(Acsm1)

HGL:	101712893(Acsm1)

CPOC:

100729957

CCAN:

109696824(Acsm1)

DORD:

DSP:

PLOP:

NCAR:

MMMA:

107146537(Acsm1)

ITI:

101974086

OCU:

100352247

OPI:

101533894

TUP:	102480423(ACSM1)

GVR:	103600529(ACSM1)

AML:	100474845(ACSM1)

UMR:	103668661(ACSM1)

UAH:	113270722(ACSM1)

UAR:	123775568(ACSM1)

ELK:

111156117

LLV:

125090827

MPUF:

101688355(ACSM1)

MNP:	132026848(ACSM1)

MLK:	131819780(ACSM1)

NVS:	122895555(ACSM1)

ORO:	101367835(ACSM1)

EJU:	114199691(ACSM1)

ZCA:	113933034(ACSM1)

MLX:

FCA:

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:	120225624 120227120 120227306 120227575

BTA:	282576(ACSM1)

BOM:	102271152(ACSM1)

BIU:	109578603(ACSM1)

BBUB:

102400565(ACSM1)

BBIS:

104986541(ACSM1)

CHX:	102182274(ACSM1)

OAS:	101120375(ACSM1)

BTAX:

128070969(ACSM1)

CSUM:

138076115(ACSM1)

ODA:	120875532(ACSM1)

CCAD:

122433375(ACSM1)

MREE:

136160581(ACSM1)

OVR:	110150436(ACSM1)

MBEZ:

129545427(ACSM1)

CFR:	102504896(ACSM1)

CBAI:

105073707(ACSM1)

CDK:	105091129(ACSM1)

VPC:	102535111(ACSM1)

BACU:

102997916 102999573 103005605 103020396

BMUS:

118880836 118881087

LVE:

103089263

OOR:	101287714 117198746

LALB:

DLE:

PCAD:

PSIU:

NASI:

112399248(ACSM1)

ECB:	100057758 106780831

EPZ:	103564591 103566614

EAI:	106839008 106841738

MYB:

102260013

MYD:

102762433

MMYO:

118652923 118656328 118656329

MLF:	102421623 102425858 102433003 102433316

MDT:	132232793 132232794 132232795 132232796 132232797

MYUM:

139008327 139008328 139009266 139009267 139009276

PKL:	118704871 118704872 118704873

EFUS:

114229714 114229717 129148666 129148786 129148787

MNA:

107544731

MMF:

118642295

PPAM:

129078111

HAI:	109386530(ACSM1)

RFQ:	117019409(ACSM1)

MJV:

108400240

TOD:	119241863 119241867

SARA:

101543727(ACSM1)

SFUM:

130045981(ACSM1)

SETR:

126031225 126031288 126031289

LAV:	100668576(ACSM1)

TMU:

101348158

ETF:

101663211

DNM:	101415550 101425882 101440527

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

Reference

PMID:11382754

Authors

Fujiwara K, Takeuchi S, Okamura-Ikeda K, Motokawa Y.

Title

Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver.

Journal

J Biol Chem 276:28819-23 (2001)
DOI:10.1074/jbc.M101748200

Sequence

[bta:282576]

Reference

PMID:16378734

Authors

Kasuya F, Tatsuki T, Ohta M, Kawai Y, Igarashi K

Title

Purification, characterization, and mass spectrometric sequencing of a medium chain acyl-CoA synthetase from mouse liver mitochondria and comparisons with the homologues of rat and bovine.

Journal

Protein Expr Purif 47:405-14 (2006)
DOI:10.1016/j.pep.2005.11.006

LinkDB

DBGET integrated database retrieval system