KEGG   ORTHOLOGY: K23828
Entry
K23828                      KO                                     
Symbol
ipaH1.4_2.5
Name
E3 ubiquitin-protein ligase IpaH1.4/2.5 [EC:2.3.2.27]
Pathway
map05131  Shigellosis
Network
nt06182  Shigella
nt06516  TNF signaling
  Element
N00945  Shigella IpaH1.4/2.5 to TNF-NFKB signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K23828  ipaH1.4_2.5; E3 ubiquitin-protein ligase IpaH1.4/2.5
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K23828  ipaH1.4_2.5; E3 ubiquitin-protein ligase IpaH1.4/2.5
Other DBs
COG: COG4886
Genes
SFL: CP0054(ipaH2.5) CP0265(ipaH1.4)
SFE: SFxv_4889(ipaH2.5) SFxv_5118(ipaH1.4)
SSN: SSON_P212(ipaH1.4)
SBO: SBO_P059(ipaH1.4)
SBC: SbBS512_A0087
SDY: SDY_P045(ipaH1.4)
Reference
PMID:27572974
  Authors
de Jong MF, Liu Z, Chen D, Alto NM
  Title
Shigella flexneri suppresses NF-kappaB activation by inhibiting linear ubiquitin chain ligation.
  Journal
Nat Microbiol 1:16084 (2016)
DOI:10.1038/nmicrobiol.2016.84
Reference
PMID:11115111
  Authors
Buchrieser C, Glaser P, Rusniok C, Nedjari H, D'Hauteville H, Kunst F, Sansonetti P, Parsot C
  Title
The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri.
  Journal
Mol Microbiol 38:760-71 (2000)
DOI:10.1046/j.1365-2958.2000.02179.x
  Sequence
[sfl:CP0265 CP0054]
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