KEGG   ORTHOLOGY: K23892
Entry
K23892            Tight     KO                                     
Symbol
ROQO
Name
mycotoxins biosynthesis cytochrome P450 monooxygenase RoqO [EC:1.14.14.-]
Pathway
map00404  Staurosporine biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R12442  
R12446  
R12448  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K23892  ROQO; mycotoxins biosynthesis cytochrome P450 monooxygenase RoqO
Other DBs
COG: COG2124
Genes
PCS: N7525_008084
Reference
PMID:23776469
  Authors
Ali H, Ries MI, Nijland JG, Lankhorst PP, Hankemeier T, Bovenberg RA, Vreeken RJ, Driessen AJ
  Title
A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum.
  Journal
PLoS One 8:e65328 (2013)
DOI:10.1371/journal.pone.0065328
  Sequence
[pcs:N7525_008084]
Reference
PMID:24225953
  Authors
Ries MI, Ali H, Lankhorst PP, Hankemeier T, Bovenberg RA, Driessen AJ, Vreeken RJ
  Title
Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway.
  Journal
J Biol Chem 288:37289-95 (2013)
DOI:10.1074/jbc.M113.512665
  Sequence
[pcs:N7525_008084]
LinkDB

KEGG   REACTION: R12446
Entry
R12446                      Reaction                               
Definition
Roquefortine L + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Glandicoline B + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C22170 + C03024 + C00007 <=> C22167 + C03161 + C00001
Comment
cytochrome P450 monooxygenase
Enzyme
1.14.14.-
Pathway
rn00404  Staurosporine biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-
     R12446  Roquefortine L + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Glandicoline B + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K23892  mycotoxins biosynthesis cytochrome P450 monooxygenase RoqO [EC:1.14.14.-]
LinkDB

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