KEGG   ORTHOLOGY: K24287
Entry
K24287                      KO                                     
Symbol
lmbB2
Name
L-tyrosine peroxygenase [EC:1.11.2.6]
Pathway
map00350  Tyrosine metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R12611  L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K24287  lmbB2; L-tyrosine peroxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.2  Peroxygenases
    1.11.2.6  L-tyrosine peroxygenase
     K24287  lmbB2; L-tyrosine peroxygenase
Genes
THIP: N838_30010
NBR: O3I_021195
NOZ: DMB37_35910
NAH: F5544_09850
SHY: SHJG_8632
SHO: SHJGH_8392
SPHW: NFX46_21415
SLS: SLINC_0235
SNZ: DC008_26540
SRK: FGW37_26110
AMD: AMED_5527
AMN: RAM_28170
AMM: AMES_5460
AMZ: B737_5460
AOI: AORI_5444
AMYY: YIM_25150
AORI: SD37_10250
KAL: KALB_5794
 » show all
Reference
PMID:8577249
  Authors
Peschke U, Schmidt H, Zhang HZ, Piepersberg W
  Title
Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11.
  Journal
Mol Microbiol 16:1137-56 (1995)
DOI:10.1111/j.1365-2958.1995.tb02338.x
  Sequence
Reference
PMID:9531633
  Authors
Neusser D, Schmidt H, Spizek J, Novotna J, Peschke U, Kaschabeck S, Tichy P, Piepersberg W
  Title
The genes lmbB1 and lmbB2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A.
  Journal
Arch Microbiol 169:322-32 (1998)
DOI:10.1007/s002030050578
LinkDB

KEGG   ENZYME: 1.11.2.6
Entry
EC 1.11.2.6                 Enzyme                                 
Name
L-tyrosine peroxygenase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases
Sysname
L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)
Reaction(IUBMB)
L-tyrosine + H2O2 = L-dopa + H2O [RN:R12611]
Reaction(KEGG)
R12611
Substrate
L-tyrosine [CPD:C00082];
H2O2 [CPD:C00027]
Product
L-dopa [CPD:C00355];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Streptomyces lincolnensis participates in the biosynthesis of the antibiotic lincomycin A, while that from Streptomyces refuineus is involved in anthramycin biosynthesis. The enzyme, which contains a heme b cofactor, is rapidly inactivated in the presence of hydrogen peroxide, but the presence of L-tyrosine protects it. cf. EC 1.11.2.5, 3-methyl-L-tyrosine peroxygenase.
History
EC 1.11.2.6 created 2020
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K24287  L-tyrosine peroxygenase
Genes
THIPN838_30010
NBRO3I_021195
NOZDMB37_35910
NAHF5544_09850
SHYSHJG_8632
SHOSHJGH_8392
SPHWNFX46_21415
SLSSLINC_0235
SNZDC008_26540
SRKFGW37_26110
SFUGCNQ36_06410
SMOBJ7W19_03340
SPRACP972_04310
SANUK7396_13290
SDDD9753_04025
STUBMMF93_32200
SLAIP8A22_34785
SLUOPS467_24905
STSDHEP87_61820
KABB7C62_33400
KCHO1G21_36960
SACGFDZ84_04225
AMDAMED_5527
AMNRAM_28170
AMMAMES_5460
AMZB737_5460
AOIAORI_5444
AABA4R43_02250
AMYYYIM_25150
AORISD37_10250
ACORLCL61_18270
KALKALB_5794
LEDBBK82_27955
AIHAiant_51630
PSUUPsuf_065210
DFUDfulv_34100
DOZHEP80_12465
 » show all
Reference
1  [PMID:9531633]
  Authors
Neusser D, Schmidt H, Spizek J, Novotna J, Peschke U, Kaschabeck S, Tichy P, Piepersberg W
  Title
The genes lmbB1 and lmbB2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A.
  Journal
Arch Microbiol 169:322-32 (1998)
DOI:10.1007/s002030050578
Reference
2  [PMID:21919439]
  Authors
Connor KL, Colabroy KL, Gerratana B
  Title
A heme peroxidase with a functional role as an L-tyrosine hydroxylase in the biosynthesis of anthramycin.
  Journal
Biochemistry 50:8926-36 (2011)
DOI:10.1021/bi201148a
Other DBs
ExplorEnz - The Enzyme Database: 1.11.2.6
IUBMB Enzyme Nomenclature: 1.11.2.6
ExPASy - ENZYME nomenclature database: 1.11.2.6
BRENDA, the Enzyme Database: 1.11.2.6
LinkDB

KEGG   REACTION: R12611
Entry
R12611                      Reaction                               
Name
L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)
Definition
L-Tyrosine + Hydrogen peroxide <=> 3,4-Dihydroxy-L-phenylalanine + H2O
Equation
Reaction class
RC00046  C00082_C00355
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.11  Acting on a peroxide as acceptor
   1.11.2  Peroxygenases
    1.11.2.6
     R12611  L-Tyrosine + Hydrogen peroxide <=> 3,4-Dihydroxy-L-phenylalanine + H2O
Orthology
K24287  L-tyrosine peroxygenase [EC:1.11.2.6]
LinkDB

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