KEGG   ORTHOLOGY: K24292
Entry
K24292                      KO                                     
Symbol
mycCI, CYP105L2
Name
mycinamicin VIII C21 methyl hydroxylase [EC:1.14.-.-]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase
   00199 Cytochrome P450
    K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.-
    1.14.-.-
     K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP105 family
   K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase
Other DBs
RN: R10875
COG: COG2124
Genes
SROI: IAG44_15950
AG: BAC57023(mycCI)
Reference
  Authors
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F
  Title
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
  Journal
FEMS Microbiol Lett 218:135-41 (2003)
DOI:10.1111/j.1574-6968.2003.tb11509.x
  Sequence
Reference
  Authors
DeMars MD 2nd, Sheng F, Park SR, Lowell AN, Podust LM, Sherman DH
  Title
Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.
  Journal
ACS Chem Biol 11:2642-54 (2016)
DOI:10.1021/acschembio.6b00479
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