KEGG ORTHOLOGY: K24996

ORTHOLOGY: K24996

Entry

K24996                      KO

Symbol

STEEP1

Name

STING ER exit protein

Disease

H00480

X-linked intellectual developmental disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K24996  STEEP1; STING ER exit protein
Membrane trafficking [BR:ko04131]
Endoplasmic reticulum (ER) - Golgi transport
  Others
   Others
    K24996  STEEP1; STING ER exit protein

Genes

HSA:	63932(STEEP1)

PTR:	473760(STEEP1)

PPS:	100990118(STEEP1) 100995507

GGO:	101138732(STEEP1) 101143621

PON:	100172581(STEEP1) 100450972

PPYG:

129025456(STEEP1) 129042621

NLE:	100583368(CXHXorf56)

HMH:	116461719 116811995(STEEP1)

SSYN:

129475562(STEEP1) 129491511

MCC:	693764(CXHXorf56)

MCF:	101925844 102139245(STEEP1)

MTHB:

126946128 126961217

MNI:	105468553(CUNHXorf56) 105476582

CSAB:

103247337(CXHXorf56)

CATY:

105590777 105598593

PANU:

101002716(CXHXorf56)

TGE:	112616484(CXHXorf56)

MLEU:

105537520

RRO:	104673876(C7HXorf56)

RBB:	108537569(CUNHXorf56)

TFN:	117077571(CUNHXorf56) 117094736

PTEH:

111531455(C12HXorf56)

CANG:

105516468

CJC:	100412357(STEEP1) 103789858

SBQ:

101048227

CIMI:

108291054(CUNHXorf56) 108297626 108309820

ANAN:

105726288 105733417(STEEP1) 105733548

CSYR:

103276204(CUNHXorf56)

MMUR:

105857158(CXHXorf56)

LCAT:

123628781(STEEP1) 123645773

PCOQ:

105806203 105817739

OGA:	100942418(CUNHXorf56)

MMU:	77644(Steep1)

MCAL:

110286755(CXHXorf56)

MPAH:

110314038(CXHXorf56)

RNO:	313433(Steep1)

MCOC:

116076685(CXHXorf56) 116090280

ANU:	117694682(CXHXorf56)

ASYL:

127675145(Steep1)

MUN:	110554590 110566444(Steep1)

CGE:	100768804(CXHXorf56)

MAUA:

101833708(Steep1) 121134134

PROB:

127217425(Steep1)

PLEU:

114704646 114705417(CXHXorf56)

MORG:

121441708 121444723

MFOT:

126488446 126510800

AAMP:

119805321(Steep1)

NGI:	103742877(CUNHXorf56)

HGL:

101697502

CPOC:

100721513(CUNHXorf56)

CCAN:

109691836(CUNHXorf56)

DORD:

105988218 105993207

DSP:	122113558 122128208(Steep1)

PLOP:

125343868(Steep1) 125350680

NCAR:

124971902

MMMA:

107153002(Steep1) 125618820

ITI:	101959780(Steep1) 110596902

OCU:	100338526(STEEP1)

OPI:	101535704(CXHXorf56)

TUP:

102494638

GVR:

103589287

CFA:	492094(STEEP1)

CLUD:

112649224(STEEP1)

VVP:	112910572(CUNHXorf56)

VLG:	121483553(STEEP1)

NPO:	129517679(STEEP1)

AML:	100477984(CXHXorf56)

UMR:	103677724(STEEP1)

UAH:	113241273(STEEP1)

UAR:	123787797(STEEP1)

ELK:

111157258

LLV:

125091971

MPUF:

101688499

MNP:	132007289(STEEP1)

MLK:	131821411(STEEP1)

NVS:	122896963(STEEP1)

ORO:

101370336

EJU:	114197004(CUNHXorf56)

ZCA:	113930749(CXHXorf56)

MLX:	118012362(CUNHXorf56)

NSU:	110577007(STEEP1)

LWW:	102737100(CUNHXorf56)

FCA:	101082887(STEEP1)

PYU:	121025479(STEEP1)

PCOO:

112870659(CUNHXorf56)

PBG:	122477887(STEEP1)

PVIV:

125157218(STEEP1)

LRUF:

124513913

LGF:	123594072(STEEP1)

AJU:	106970834(STEEP1)

PTG:

102967344

PPAD:

109250768(CUNHXorf56)

PUC:

125932264

HHV:	120222134(STEEP1)

BTA:	504687(STEEP1)

BOM:	102276220(STEEP1)

BIU:	109572259(C18HXorf56)

BBUB:

102415839(STEEP1)

CHX:	102173372(CUNHXorf56)

OAS:	121818263(STEEP1)

BTAX:

128070218(STEEP1)

CSUM:

138071382(STEEP1) 138097653

ODA:	120881445(STEEP1)

CCAD:

122435057(STEEP1)

MREE:

136153241(STEEP1)

OVR:	110133869(STEEP1)

MBEZ:

129534896(STEEP1)

SSC:	100152936(CXHXorf56)

CFR:	102514557(CXHXorf56)

CBAI:

105062973

CDK:	105093931(CXHXorf56)

VPC:	102525701(CXHXorf56)

BACU:

103005541

BMUS:

118889495(CUNHXorf56)

LVE:

103090607

OOR:	101276025(STEEP1) 101287564

LALB:

132508836 132513291(STEEP1)

DLE:	111169061(CUNHXorf56)

PCAD:

102974444(STEEP1)

PSIU:

116743279 116748138(CXHXorf56)

PPHC:

136142969(STEEP1)

NASI:

112404038(CUNHXorf56)

ECB:	100059026(CXHXorf56)

EPZ:	103542836(STEEP1)

EAI:	106841504(STEEP1)

MYB:

102256442

MYD:

102755838

MMYO:

118650235 118654029(CUNHXorf56)

MLF:	102422925(CUNHXorf56)

MDT:	132223316(STEEP1) 132228605

MYUM:

139004901(STEEP1)

PKL:	118722195(CUNHXorf56) 118728486

EFUS:

103288180 103290178 103299976(STEEP1)

MNA:

107529343

DRO:	112310863(CUNHXorf56)

SHON:

118993208 119003022(STEEP1)

AJM:	119047153 119062998(STEEP1)

PDIC:

114505336(CXHXorf56) 114508494

PHAS:

123805108(STEEP1) 123807587

MMF:	118622829 118636155(CUNHXorf56)

PPAM:

129064677 129076117(STEEP1)

HAI:	109396194(CUNHXorf56)

RFQ:	117027998(C1HXorf56)

PALE:

102895799(CUNHXorf56)

PGIG:

120586044(STEEP1)

PVP:	105305548(CUNHXorf56)

RAY:	107506540(CUNHXorf56)

MJV:	108389562(CUNHXorf56)

TOD:	119245937(STEEP1)

SARA:

101539703 101542863

SFUM:

130034236(STEEP1) 130034593

SETR:

125999537(STEEP1)

LAV:	100664386(CUNHXorf56)

TMU:

101342010

ETF:	101639560(STEEP1) 101652518

DNM:	101438197(CUNHXorf56)

MDO:	100011766(CXHXorf56)

GAS:	123253396(STEEP1)

SHR:	100932302(CXHXorf56)

AFZ:	127543040 127562334

PCW:	110200043(CUNHXorf56)

TVP:	118832740(CXHXorf56) 118834324

PBRV:

138172417(STEEP1)

OAA:	100080485(STEEP1)

TACU:

119930082(STEEP1)

GGA:	428719(C4HXorf56)

PCOC:

116234883(CUNHXorf56)

MGP:	100545333(C9HXorf56)

CJO:	107312947(C4HXorf56)

TPAI:

128076059(STEEP1)

LMUT:

125699835(STEEP1)

NMEL:

110403108(C8HXorf56)

APLA:

101791222(STEEP1)

ACYG:

106037650(STEEP1)

CATA:

118245269(STEEP1)

AFUL:

116494282(C13HXorf56)

TGU:	100223622(C4AHXorf56)

LSR:	110480481(STEEP1)

SCAN:

103816403(CUNHXorf56)

PMOA:

120506217(STEEP1)

OTC:	121331849(STEEP1)

PRUF:

121363228(STEEP1)

ATRC:

139597265(STEEP1)

GFR:

102037769

FAB:	101809397(C4AHXorf56)

OMA:	130253273(STEEP1)

PHI:

102110521

PMAJ:

107203816(C4AHXorf56)

CCAE:

111944841(CUNHXorf56)

CCW:	104694425(STEEP1)

CBRC:

103621633(CUNHXorf56)

ACOE:

138110421(STEEP1)

ETL:	114065753(CUNHXorf56)

ZAB:	102062938(CUNHXorf56)

ZLE:	135447568(STEEP1)

ACHL:

103799483

SVG:

106859483

MMEA:

130573290(STEEP1)

SATI:

136374113(STEEP1)

CCIC:

134050192(STEEP1)

FPG:

101923951

FCH:	102050612(CUNHXorf56)

CCRI:

104156720

NNT:

104400273

SHAB:

115613263(C9HXorf56)

ACUN:

113480144(C4HXorf56)

TALA:

104362949(STEEP1)

ACHC:

115333489(STEEP1)

HLE:

104832662

AGEN:

126050373

HHAR:

128153635(STEEP1)

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

135184047(STEEP1)

BRHI:

104498323

EGZ:	104124088(CUNHXorf56)

NNI:

PCRI:

PCAO:

PADL:

AFOR:

103895653(CUNHXorf56)

FGA:

104071446

GSTE:

104252649

CBOY:

140658559(STEEP1)

CLV:	102090271(CUNHXorf56)

CNIC:

135993294(STEEP1)

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

104064052(STEEP1)

TEO:

BREG:

OHA:

CVF:

RTD:	128914514(STEEP1)

CRID:

134521210(STEEP1)

AAM:

106487562

AROW:

112963716(CUNHXorf56)

NPD:	112947105(CUNHXorf56)

TGT:

104565357

DNE:	112997236(CUNHXorf56)

SCAM:

104142213

ASN:	102369222(CUNHXorf56)

AMJ:	102562756(CUNHXorf56)

CPOO:

109313589(CUNHXorf56)

GGN:	109300785(CUNHXorf56)

PSS:	102456354(CUNHXorf56)

CMY:	102936125(STEEP1)

CCAY:

125643003(STEEP1)

DCC:	119861786(STEEP1)

CPIC:

101946778(STEEP1)

TST:	117883243(C9HXorf56)

CABI:

116817184(CUNHXorf56)

MRV:	120371239(STEEP1)

ASAO:

132762840(STEEP1)

PVT:	110090268(CUNHXorf56)

SUND:

121936293(STEEP1)

PBI:	103061115(CUNHXorf56)

PMUR:

107299531(CUNHXorf56)

CTIG:

120316612(STEEP1)

TSR:

106549160

PGUT:

117670622(STEEP1)

PCAE:

139322669(STEEP1)

APRI:

131204973(STEEP1)

PTEX:

113437767(CUNHXorf56)

NSS:	113425587(CUNHXorf56)

VKO:	123022087(STEEP1)

PMUA:

114589331(CZHXorf56)

PRAF:

128405414 128406859(STEEP1)

ZVI:	118084436(LG4HXorf56) 118097854

HCG:	128335260(STEEP1)

GJA:

107123732

STOW:

125443060(STEEP1)

EMC:	129340902(STEEP1)

XLA:	373791(steep1.L)

XTR:	394969(cxorf56)

NPR:	108785626(CUNHXorf56)

RTEM:

120913015(STEEP1)

ACAT:

141108813(STEEP1)

BBUF:

120977704(STEEP1)

BGAR:

122946732(STEEP1)

DTC:	141059901(STEEP1)

PWL:	138261279(STEEP1)

MUO:	115474503(C7HXorf56)

GSH:	117360443(C5HXorf56)

DRE:	447921(steep1)

SRX:	107746415 107757513

SANH:

107655899 107700899

SGH:	107548454 107596198

CCAR:

109084977 109098031

CAUA:

113049550 113076283

CGIB:

127957011 128005344

PTET:

122344765(steep1)

LROH:

127165186(steep1)

GRF:	141335806(steep1)

OMC:	131541217(steep1)

PPRM:

120461853(steep1)

MAMB:

125266410(steep1)

CIDE:

127513349

CERY:

137033990(steep1)

MASI:

127422977 127435388

TROS:

130545270

TDW:	130419853(steep1)

MANU:

129440366(steep1)

PDAB:

135748611(steep1)

IPU:	100528407(steep1)

SMEO:

124379072(steep1)

TFD:	113637780(steep1)

TVC:	132840853(steep1)

CGAR:

128512430(steep1)

NGRA:

132875965(steep1)

TRN:	134303366(steep1)

AMEX:

103039023(steep1)

CMAO:

118814518(cunhxorf56)

EEE:	113569364(cunhxorf56)

CHAR:

105896235(steep1)

SPIL:

134080582(steep1)

TRU:	115251050(c9hxorf56)

TFS:	130536456(steep1)

TNG:	GSTEN00016788G001

LCO:

104938431

NCC:

104953698

TBEN:

117491330(cunhxorf56)

CGOB:

115009580(c6hxorf56)

PGEO:

117447497(steep1)

GACU:

117542815(cunhxorf56)

EMAC:

134880207(steep1)

ELY:	117250911(cunhxorf56)

EFO:	125887940(steep1)

PLEP:

121950546(steep1)

SLUC:

116053025(c7hxorf56)

ECRA:

117948454(c8hxorf56)

ESP:	116693667(c8hxorf56)

PFLV:

114560376(c8hxorf56)

GAT:	120809464(steep1)

PPUG:

119196023(steep1)

AFB:	129108766(steep1)

CLUM:

117732335(c6hxorf56)

PSWI:

130194969 130195600

CANA:

137804163(steep1)

CVE:	137881738(steep1)

MSAM:

119893525 119893592

SCHU:

122874771(steep1)

CUD:	121515558(steep1)

SPUL:

138613280(steep1)

LMIX:

132973350(steep1)

ALAT:

119024360(c8hxorf56)

ASTR:

137594162(steep1)

MZE:

101478835

ONL:	100696719(lg7hxorf56)

OAU:	116326341(steep1)

OML:	112152746(lg6hxorf56)

CSAI:

133444671(steep1)

XMA:	102220759(c2hxorf56)

XCO:	114137484(c2hxorf56)

XHE:	116708635(c2hxorf56)

PRET:

103466825(clg6hxorf56)

PFOR:

103129271

PLAI:

106957096

PMEI:

106907577

GAF:	122835090(steep1)

PPRL:

129360071

CVG:

107084290

CTUL:

119789132(steep1)

GMU:	124856954(steep1)

NFU:	107389313(csgr13hxorf56)

KMR:	108237461(lg11hxorf56)

ALIM:

106536734

NWH:	119415545(steep1)

AOCE:

111576297(steep1)

EJA:	138206555(steep1)

BFRE:

138624827(steep1)

MCEP:

125014825(steep1)

CSEM:

103379552(c6hxorf56)

POV:	109623706(cunhxorf56)

SSEN:

122761010(steep1)

SSOE:

131470143(steep1)

HHIP:

117763544(c6hxorf56)

HSP:	118110188(steep1)

PPLT:

128444913(steep1)

SMAU:

118315698(steep1)

LCF:	108901914(steep1)

SDU:	111225200(cunhxorf56)

SLAL:

111666051(cunhxorf56)

XGL:	120792760(steep1)

HCQ:	109526776(cunhxorf56)

SSCV:

125970172(steep1)

SBIA:

133502534(steep1)

PEE:	133402493(steep1)

PTAO:

133477793(steep1)

BPEC:

110169644(cunhxorf56)

ENY:	140348709(steep1)

MALB:

109962546(cunhxorf56)

BSPL:

114857045(steep1)

SJO:	128358818(steep1)

SSCO:

133981792 133982144

GMH:

115551306

SASA:

106567781(cssa13hxorf56)

STRU:

115149084(c15hxorf56)

OTW:	112257668(steep1)

OMY:	110537281(c12hxorf56)

OGO:	124000050(steep1)

ONE:	115105744(lg22hxorf56)

OKI:	109892587(lg6hxorf56)

OKE:	118391332(steep1)

OMM:	135548412(steep1)

OCLA:

139422946

SALP:

111981995(lg20hxorf56)

SNH:	120044273(steep1)

CCLU:

121573727(steep1)

ELS:	105025026(lg07hxorf56)

OEP:	134040104(steep1)

SFM:	108920032(c14hxorf56)

PKI:	111855225(cunhxorf56)

AANG:

118234894(c9hxorf56)

AROT:

135262960(steep1)

CCOG:

133133157(steep1)

LOC:	102687562(clg7hxorf56)

PSPA:

121295834(steep1)

ARUT:

117412615 117430771

PSEX:

120537434(steep1)

LCM:

102360882

CMK:	103179185(steep1)

RTP:	109929991(steep1)

CPLA:

122557395(steep1)

HOC:	132820122(steep1)

LERI:

129702336(steep1)

HAKA:

140734207(steep1)

PMRN:

116955139(C3HXorf56)

LRJ:	133347770(STEEP1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG16865(CG16865)

DER:

6540924

DSE:

6611198

DSI:	Dsimw501_GD23925(Dsim_GD23925)

DYA:	Dyak_GE18683

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18239

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108356308 108361015

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

109410273 109411086 115266547

ASUA:

134215850

CQU:	CpipJ_CPIJ000055

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:	115877054 115879105

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_203732

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

CFEL:

CCRN:

API:

DNX:

AGS:	114131528 126555262

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

MQU:

PHU:	Phum_PHUM454190

FOC:

TPAL:

ZNE:

CSEC:

PAME:

SGRE:

BROR:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_302813

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

PORN:

HAZT:

EAF:

LSM:	121131409 121132651

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

GOE:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_Y66D12A.8(Y66D12A.8)

CBR:

CBG_13259

CRQ:	GCK72_010242

NAI:	NECAME_15401

BMY:	BM_BM6980(Bm6980)

LOA:	LOAG_04959

TSP:

Tsp_04071

HRO:	HELRODRAFT_96112

LGI:	LOTGIDRAFT_184723

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111123419 111125860

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106161346 106177889

SMM:	Smp_007380

SHX:	MS3_00009871

OVI:	T265_15146

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:	114537780 114537945

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_53219

AQU:

100633564

» show all

Reference

PMID:32690950

Authors

Zhang BC, Nandakumar R, Reinert LS, Huang J, Laustsen A, Gao ZL, Sun CL, Jensen SB, Troldborg A, Assil S, Berthelsen MF, Scavenius C, Zhang Y, Windross SJ, Olagnier D, Prabakaran T, Bodda C, Narita R, Cai Y, Zhang CG, Stenmark H, Doucet CM, Noda T, Guo Z, Goldbach-Mansky R, Hartmann R, Chen ZJ, Enghild JJ, Bak RO, Thomsen MK, Paludan SR

Title

STEEP mediates STING ER exit and activation of signaling.

Journal

Nat Immunol 21:868-879 (2020)
DOI:10.1038/s41590-020-0730-5

Sequence

[hsa:63932]

LinkDB

DBGET integrated database retrieval system