KEGG ORTHOLOGY: K25113

ORTHOLOGY: K25113

Entry

K25113                      KO

Symbol

htsA, isdE

Name

heme transport system substrate-binding protein

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K25113  htsA, isdE; heme transport system substrate-binding protein
Transporters [BR:ko02000]
ABC transporters, prokaryotic type
  Metallic cation, iron-siderophore and vitamin B12 transporters
   Heme transporter
    K25113  htsA, isdE; heme transport system substrate-binding protein

Other DBs

COG:

COG0614

TC:

3.A.1.14

Genes

TDE:	TDE_1180 TDE_2356

TPED:

TPE_0067 TPE_1650

TPK:	JO40_08605

BSON:

BAN:

BAR:

BAT:

BAH:	BAMEG_4818

BAI:

BAA_4799

BAX:	H9401_4568

BANT:

BANR:

BANS:

BANH:

BANV:

DJ46_3455(isdE)

BAL:	BACI_c45370

BCE:

BC4546

BCA:

BCE_4670

BCZ:	BCE33L4291

BCR:	BCAH187_A4673

BCB:	BCB4264_A4655

BCU:	BCAH820_4660

BCG:	BCG9842_B0582

BCQ:

BCX:

BNC:

BCF:

BCER:

BCEF:

BTK:	BT9727_4280

BTL:	BALH_4130(fatB)

BTB:	BMB171_C4191

BTT:

HD73_4840

BTHR:

YBT1520_24015

BTHI:

BTK_23855

BTC:	CT43_CH4566

BTF:	YBT020_22345

BTM:

MC28_3826

BTG:	BTB_c46950(isdE2)

BTI:

BTG_26145

BTN:	BTF1_21270

BTHT:

H175_ch4639

BTHU:

YBT1518_25145

BTW:	BF38_299(isdE)

BTHY:

AQ980_07160

BWE:	BcerKBAB4_4374

BWW:	bwei_0350(isdE)

BMYO:

BG05_1497(isdE)

BTY:	Btoyo_1784

BBY:	CY96_21870

BWD:	CT694_24290(isdE)

BTRO:

FJR70_16475(isdE)

BMOB:

MLA2C4_23625(isdE)

BNT:	GSN03_21595(isdE)

BPAC:

LMD38_04190(isdE)

BPAN:

NLJ82_22245(isdE)

BALU:

QRY64_25620(isdE)

BAAP:

BGI23_21955

BPAM:

AABL52_04800(isdE)

BPU:

BPUM_3526

BPUM:

BW16_18680

BPUS:

UP12_18095

BXI:	BK049_09320

BALT:

CFN77_18610(isdE)

BAER:

BAE_06460(isdE)

BSAF:

BSL056_19225

BACW:

QR42_17660

BZH:	NF868_16225(isdE)

BASD:

LCG60_03755(isdE)

BAEZ:

DPQ26_25595(isdE)

BAAZ:

GD442_22305(isdE)

BABD:

EKQ63_24195(isdE)

NTX:	NQZ71_16925(isdE)

NIL:	L8T27_005050(isdE)

BHA:

BH3297

BCL:

ABC3422

BLE:	BleG1_3396

SHUA:

PQ477_04630(isdE)

BKO:	CKF48_02515(isdE)

LSP:

Bsph_1267

LGY:	T479_03685

LFU:	HR49_18235 HR49_19830

LYB:	C3943_04630(isdE)

LYZ:	DCE79_03335(isdE)

LPAK:

GDS87_03925(isdE)

LAGR:

FJQ98_04700(isdE)

LYC:	FH508_0003750(isdE) FH508_0005735 FH508_0007390(isdE)

LIU:	OU989_04990

LLB:	R6U77_01075(isdE) R6U77_10935

LYQ:	MY533_03070(isdE)

LYO:	NV349_03790(isdE) NV349_05375 NV349_06675(isdE)

TAP:	GZ22_12810

VIG:	BKP57_15750

VPN:	A21D_01193(isdE_1)

ACOP:

RI196_16480(isdE)

BMUR:

ABE28_021370

PSYH:

D0S48_18370

PSYB:

KD050_06660

SLMS:

MM221_02305(isdE)

ALKL:

MM271_02620(isdE)

SAU:	SA0980(isdE)

SAV:

SAV1133

SAW:

SAHV_1124

SAH:	SaurJH1_1214

SAJ:	SaurJH9_1192

SAM:	MW1015(isdE)

SAS:

SAS1067

SAR:	SAR1106(isdE)

SAC:

SACOL1143

SAX:	USA300HOU_1067(isdE)

SAA:	SAUSA300_1032

SAO:	SAOUHSC_01085

SAE:	NWMN_1044(isdE)

SAD:	SAAV_1099(isdE)

SUU:	M013TW_1066(isdE)

SUV:	SAVC_04825

SUE:	SAOV_1129(isdE)

SUJ:	SAA6159_00987(isdE)

SUK:	SAA6008_01087(isdE)

SUC:

ECTR2_987

SUT:	SAT0131_01172

SUQ:	HMPREF0772_12100(isdE)

SUZ:	MS7_1089(isdE)

SUD:	ST398NM01_1129

SUX:	SAEMRSA15_09620(isdE)

SUW:	SATW20_11270(isdE)

SUG:

SAPIG1129

SUF:	SARLGA251_10450(isdE)

SAUA:

SAAG_02241

SAUE:

RSAU_001017(isdE)

SAUN:

SAKOR_01054

SAUS:

SA40_1003(isdE)

SAUU:

SA957_1018(isdE)

SAUG:

SA268_1021(isdE)

SAUZ:

SAZ172_1132(isdE)

SAUT:

SAUJ:

SAUK:

SAUQ:

SAUV:

SAI7S6_1008060(isdE)

SAUW:

SAI5S5_1008020(isdE)

SAUX:

SAI6T6_1008030(isdE)

SAUY:

SAI8T7_1008060(isdE)

SAUF:

X998_1130(isdE)

SAB:	SAB0997(isdE)

SUY:	SA2981_1089(isdE)

SAUB:

C248_1159(isdE)

SAUM:

BN843_10370

SAUC:

CA347_1047(isdE)

SAUR:

SAUI:

SAUD:

SAMS:

SUH:	SAMSHR1132_09790

SLG:	SLGD_00068 SLGD_00097

SLN:	SLUG_00960(isdE)

SCAP:

AYP1020_0457(isdE)

SSIF:

AL483_06770(isdE)

SCV:	A4G25_07645

SCAR:

DWB96_08975(isdE)

SSH:	NCTC13712_01077(isdE)

SAUL:

I6G39_10250(isdE)

SROT:

ML435_05170(isdE)

SSCU:

CEP64_00970(isdE)

LMO:

lmo2184

LMN:	LM5578_2387

LMY:	LM5923_2338

LMT:	LMRG_01648

LMOC:

LMOE:

LMOB:

LMOD:

LMOW:

LMOQ:

LM6179_02962(isdE)

LMR:	LMR479A_2296(isdE)

LMOM:

IJ09_13990

LMF:	LMOf2365_2217

LMC:	Lm4b_02210

LMOG:

BN389_22180(isdE)

LMP:

MUO_11215

LMOL:

LMOL312_2203

LMOJ:

LM220_20610

LMOZ:

LM1816_17280(isdE)

LMOX:

AX24_08830

LMH:	LMHCC_0359

LMQ:	LMM7_2286(fecB)

LML:	lmo4a_2245

LMG:	LMKG_00125

LMS:

LMLG_0839

LMJ:	LMOG_01030

LMW:	LMOSLCC2755_2252

LMX:	LMOSLCC2372_2252

LMZ:	LMOSLCC2482_2250

LMON:

LMOS:

LMOO:

LMOY:

LMOT:

LMOA:

LMOK:

LMV:	Y193_04565(isdE)

LIN:

LWE:

LSG:

LIV:

LII:	JL52_11405

LIW:	AX25_11600

LIA:	JL58_11590

LIO:	JL53_12090

LMAR:

LAX80_010720(isdE)

LNW:	OTR81_05755

BTHS:

CNY62_10210(isdE)

GOT:	AXE85_02270

GMO:	NCTC11323_01372(isdE)

GEQ:	CG018_04040(isdE)

GSA:	FOC50_06435(isdE)

GHA:	NCTC10459_01393(isdE)

BAGR:

BPAB:

BREH:

BREP:

PJD:	Pjdr2_0793

PPY:

PPE_04034

PPM:	PPSC2_21300(fhuD1)

PPO:	PPM_4246(fhuD1)

PPOL:

X809_37330

PPQ:	PPSQR21_043060

PPOY:

RE92_15950

PTA:	HPL003_02730

PAEE:

R70331_22570

PPEO:

ABE82_21260

PNP:	IJ22_07900

PBV:	AR543_21240

PKB:	B4V02_04145

PAIH:

ASL14_16720

PCEL:

HUB94_04450(isdE)

PTHI:

NDS46_13435

PKA:	PQ456_18560(isdE)

PDY:	QJQ58_08620

PMAE:

LMZ02_10375(isdE)

PSPN:

L1F29_02085

PPOG:

QPK24_03620

PHK:	SK066_19650(isdE)

PNK:	AASFL403_00515(isdE)

PKP:	SK3146_04311(isdE_2)

PLZH:

C0638_12150(isdE)

PELG:

ACJ7K1_05150(isdE)

PASZ:

KAI36_04517(btuF_3)

PLIG:

NAG76_10705(isdE)

SIV:

SSIL_3206

SSIL:

SOLI23_02530

SOB:	CSE16_18250

KUR:	ASO14_2976 ASO14_692(isdE)

KZO:	NCTC404_00832(isdE_1) NCTC404_03053(isdE_2)

SPSY:

SPOR:

SPOP:

SURE:

SPOS:

DV702_00275 DV702_13425(isdE)

SPAE:

E2C16_01130(isdE)

SPOO:

J3U78_10825 J3U78_19375(isdE)

SURL:

BI350_04760

SOW:	QWT69_03475(isdE)

SPOH:

GGGNBK_05650(isdE) GGGNBK_20670

VIJ:	JNUCC6_14885

SPY:

SPy_1795

SPZ:	M5005_Spy1528

SPYA:

A20_1577c(isdE)

SPM:	spyM18_1867

SPG:	SpyM3_1560(fhuD.2)

SPS:

SPs0307

SPH:	MGAS10270_Spy1596

SPI:	MGAS10750_Spy1587

SPJ:	MGAS2096_Spy1555

SPK:	MGAS9429_Spy1532

SPF:

SpyM50318

SPA:	M6_Spy1521

SPB:	M28_Spy1518

STG:	MGAS15252_1374(htsA)

STX:	MGAS1882_1435(htsA)

SOZ:	Spy49_1403c(fhuD2)

STZ:	SPYALAB49_001520(isdE)

SPYH:

L897_07365

SPYO:

STAB901_07410

SEZ:

Sez_0373

SEQ:	SZO_16050(htsA)

SEQU:

Q426_07425

SEU:	SEQ_0446(htsA)

SDS:

SDEG_1862

SDG:	SDE12394_09215

SDA:	GGS_1677(fhuD)

SDC:

SDSE_1943

SDQ:	SDSE167_1920

SIK:

K710_1794

SIQ:	DQ08_08430

SIO:	DW64_08415

SIZ:	SI82_08525

SCAI:

NCTC12191_00980(fhuD2)

SURN:

NCTC13766_00999(isdE_1)

LCR:	LCRIS_01467

LFE:

LAF_0152

LFR:

LC40_0111

LFF:

LBFF_0164

LGAS:

LG045_02400(isdE)

LNG:	BSQ50_10690

LHW:	BSQ49_09330

LMAL:

LM596_09750

LBH:

Lbuc_1622

LBN:	LBUCD034_1680(fepB)

LPAR:

FAM21731_01816

LCU:	PL11_001260

LKF:	DNL43_00530(isdE)

LHIL:

G8J22_01910(isdE)

LBR:

LVIS_0699

LBK:	LVISKB_0710

LKO:	ABN16_01290

LACA:

LAC1533_0089

LCY:	LC20004_11410

LHO:	LOOC260_117490

LPD:	AYR62_12160

LMAE:

FGL90_04785(isdE)

LLF:	BCR17_00435

LGC:	A9176_06230

WCE:

WS08_0978

WTR:	KHQ32_05480

WCT:

WS74_1044

WCI:	WS105_1040

WCB:	AO080_01985

WJO:	FOL01_2007

WPA:	CO680_08240

WCF:	C6P13_00040

WSO:	WSWS_01408

WVR:	IE337_00055

WSA:	AB9G37_07405

WEI:	EQG49_03195

AUR:	HMPREF9243_1900

AUN:	AWM73_00570

ALOY:

CJ190_000730

AMIT:

DBT49_0000795

ATJ:	DBT50_006780

CML:	BN424_3053(isdE)

CDJ:	BFC22_06655

CPE:

CPF:

CPR:

CTC:

CTET:

CNO:	NT01CX_1446

CBN:

CbC4_0607

CLT:	CM240_0244

CLD:	CLSPO_c13030

CCHV:

BTM20_11955

CARG:

RSJ17_04635

CSEP:

CP523_10325(isdE) CP523_11320

CCAA:

KQH81_12565(isdE)

ASF:

SFBM_0991

ASM:	MOUSESFB_0927

ASO:	SFBmNL_01066

ASB:	RATSFB_0845

HHW:	NCTC503_01749(isdE)

CPRF:

K7H06_02290(isdE) K7H06_02335(isdE)

CLO:	HMPREF0868_0211

FSA:	C5Q98_07655

SMAN:

C12CBH8_17720

OKO:	Ruko_30750

HMB:	ACI0CA_13600

SGY:

Sgly_1486

ELIM:

B2M23_09650

IBU:	IB211_01898c

CCT:	CC1_09200 CC1_29080

BLAB:

EYS05_00475(isdE)

BHV:	BLHYD_01350(btuF)

LSIA:

VIG27_15030(isdE)

BPRL:

CL2_23080

ACEL:

acsn021_02660

RGN:	RGna_12770(isdE)

SCAZ:

ACI3DN_13110(isdE)

LBX:	lbkm_0289 lbkm_2156

VGU:	HYG85_03010

VPY:	HZI73_08940

EUU:	ADJ67_05255

AOE:

Clos_0310

GFE:	Gferi_09815

PBIF:

KXZ80_04625

PSOR:

RSJ16_04630

ROC:	HF520_03525(isdE) HF520_04240

RIL:

CRIB_901

RHOM:

FRIFI_1794

TGC:	L0P85_10475(isdE)

IBR:	NQ514_08545(isdE)

PANB:

M1L67_06530(isdE)

AMEI:

LV469_00445(isdE)

PGK:	M9426_08030(isdE)

HOV:	EQF90_002615(isdE)

HKU:	HIF96_01635

CAD:	Curi_c03690

CAZO:

AIN:

PFAC:

AMUO:

TSG:	HLK68_07470

FIT:	Fi14EGH31_00370

ERM:	EYR00_01035(isdE)

TSF:	NQ543_10735(isdE)

CALK:

HUE98_13850

EGD:	GS424_015310(isdE)

DDT:	AAY81_07915

BWA:	HLV38_03510(isdE)

LXX:

Lxx07340

LXY:	O159_07890

GCR:	GcLGCM259_2696

TLE:

Tlet_1251

TFE:	JYK00_07280

FTHL:

U0O82_06365(isdE)

FVA:	FV113G1_21370

FUL:	C4N20_15965

FMO:	C4N19_10515

» show all

Reference

PMID:14500516

Authors

Lei B, Liu M, Voyich JM, Prater CI, Kala SV, DeLeo FR, Musser JM

Title

Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenes.

Journal

Infect Immun 71:5962-9 (2003)
DOI:10.1128/IAI.71.10.5962-5969.2003

Sequence

[spy:SPy_1795]

Reference

PMID:18184657

Authors

Liu M, Tanaka WN, Zhu H, Xie G, Dooley DM, Lei B

Title

Direct hemin transfer from IsdA to IsdC in the iron-regulated surface determinant (Isd) heme acquisition system of Staphylococcus aureus.

Journal

J Biol Chem 283:6668-76 (2008)
DOI:10.1074/jbc.M708372200

LinkDB

DBGET integrated database retrieval system