KEGG ORTHOLOGY: K25234

ORTHOLOGY: K25234

Entry

K25234                      KO

Symbol

ambE

Name

L-glutamate---[L-glutamyl-carrier protein] ligase [EC:6.2.1.68]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K25234  ambE; L-glutamate---[L-glutamyl-carrier protein] ligase
Enzymes [BR:ko01000]
6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.68  L-glutamate---[L-glutamyl-carrier protein] ligase
     K25234  ambE; L-glutamate---[L-glutamyl-carrier protein] ligase
Polyketide biosynthesis proteins [BR:ko01008]
Nonribosomal peptide synthetase (NRPS)
  Linear NRPS
   L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
    K25234  ambE; L-glutamate---[L-glutamyl-carrier protein] ligase

Other DBs

COG:	COG1020 COG3208

Genes

PAE:	PA2302(ambE)

PAEV:

N297_2375

PAEI:

N296_2375

PAU:	PA14_34840

PAG:	PLES_30021

PAF:	PAM18_2738

PNC:	NCGM2_3312

PAEB:

NCGM1900_4228

PDK:	PADK2_13760

PSG:	G655_13540

PAEP:

PAER:

PAEM:

PAEL:

PAES:

PAEU:

PAEG:

PAEC:

PAEO:

SECH:

SRPA:

SSIR:

MTEM:

MFEU:

MHAW:

Reference

PMID:25814981

Authors

Rojas Murcia N, Lee X, Waridel P, Maspoli A, Imker HJ, Chai T, Walsh CT, Reimmann C.

Title

The Pseudomonas aeruginosa antimetabolite L -2-amino-4-methoxy-trans-3-butenoic acid (AMB) is made from glutamate and two alanine residues via a thiotemplate-linked tripeptide precursor.

Journal

Front Microbiol 6:170 (2015)
DOI:10.3389/fmicb.2015.00170

Sequence

[pae:PA2302]

LinkDB

DBGET integrated database retrieval system