KEGG   ORTHOLOGY: K25332
Entry
K25332                      KO                                     
Symbol
NS5
Name
Flavivirus RNA-directed RNA polymerase NS5 [EC:2.1.1.56. 2.1.1.57 2.7.7.48]
Pathway
map03240  Viral replication
map03264  Virion - Flavivirus and Alphavirus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03240 Viral replication
    K25332  NS5; Flavivirus RNA-directed RNA polymerase NS5
   03264 Virion - Flavivirus and Alphavirus
    K25332  NS5; Flavivirus RNA-directed RNA polymerase NS5
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K25332  NS5; Flavivirus RNA-directed RNA polymerase NS5
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.57  methyltransferase cap1
     K25332  NS5; Flavivirus RNA-directed RNA polymerase NS5
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.48  RNA-directed RNA polymerase
     K25332  NS5; Flavivirus RNA-directed RNA polymerase NS5
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Flavivirus
   K25332  NS5; Flavivirus RNA-directed RNA polymerase NS5
Other DBs
GO: 0004482 0004483 0003968
Genes
VP: 1489713-8(NS5) 1489715-2(NS5) 1489719-8(NS5) 1494449-8(NS5) 1502173-2(NS5) 1724640-1(NS5) 27964207-1(NS5) 2943111-1(NS5) 37627194-1(NS5) 40338747-1(NS5) 40524942-1(NS5) 5075725-8(NS5) 5075727-8(NS5) 5075729-8(NS5) 5075791-1(NS5) 5075856-2(NS5) 5075863-2(NS5) 5075867-2(NS5) 7751225-8(NS5) 7943824-1(NS5) 912267-8(NS5) 940442-1(NS5) 940444-1(NS5)
Reference
PMID:31090058
  Authors
Saw WG, Chan KW, Vasudevan SG, Gruber G
  Title
Zika virus nonstructural protein 5 residue R681 is critical for dimer formation and enzymatic activity.
  Journal
FEBS Lett 593:1272-1291 (2019)
DOI:10.1002/1873-3468.13437
  Sequence
[vp:7751225-8]
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