KEGG ORTHOLOGY: K25364

ORTHOLOGY: K25364

Entry

K25364                      KO

Symbol

Name

lombricine kinase [EC:2.7.3.5]

Pathway

map00470

D-Amino acid metabolism

map01100

Metabolic pathways

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09106 Metabolism of other amino acids
   00470 D-Amino acid metabolism
    K25364  LK; lombricine kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.3  Phosphotransferases with a nitrogenous group as acceptor
    2.7.3.5  lombricine kinase
     K25364  LK; lombricine kinase

Other DBs

RN:

R03691

GO:

0050059

Genes

AG:	AAM10823 BAA22872

Reference

PMID:9434106

Authors

Suzuki T, Kawasaki Y, Furukohri T, Ellington WR

Title

Evolution of phosphagen kinase. VI. Isolation, characterization and cDNA-derived amino acid sequence of lombricine kinase from the earthworm Eisenia foetida, and identification of a possible candidate for the guanidine substrate recognition site.

Journal

Biochim Biophys Acta 1343:152-9 (1997)
DOI:10.1016/s0167-4838(97)00128-3

Sequence

[ag:BAA22872]

Reference

PMID:11866456

Authors

Ellington WR, Bush J

Title

Cloning and expression of a lombricine kinase from an echiuroid worm: insights into structural correlates of substrate specificity.

Journal

Biochem Biophys Res Commun 291:939-44 (2002)
DOI:10.1006/bbrc.2002.6539

Sequence

[ag:AAM10823]

LinkDB

ENZYME: 2.7.3.5

Entry

EC 2.7.3.5                  Enzyme

Name

lombricine kinase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a nitrogenous group as acceptor

Sysname

ATP:lombricine N-phosphotransferase

Reaction(IUBMB)

ATP + lombricine = ADP + N-phospholombricine [RN:R06976]

Reaction(KEGG)

R06976;
(other) R03691

Substrate

ATP [CPD:C00002];
lombricine [CPD:C14177]

Product

ADP [CPD:C00008];
N-phospholombricine [CPD:C14178]

Comment

Also acts on methylated lombricines such as thalassemine; the specificity varies with the source species.

History

EC 2.7.3.5 created 1965, modified 1976

Pathway

ec00470

D-Amino acid metabolism

ec01100

Metabolic pathways

Orthology

K25364

lombricine kinase

Reference

1 [PMID:5832288]

Authors

Gaffney TJ, Rosenberg H, Ennor AH.

Title

The purification and properties of adenosine triphosphate-lombricine phosphotransferase.

Journal

Biochem J 90:170-6 (1964)
DOI:10.1042/bj0900170

Reference

2 [PMID:5840960]

Authors

Kassab R, Pradel LA, Nguyen Van Thoai.

Title

[ATP:taurocyamine and ATP:lombricine phosphotransferases. Purification and study of SH groups]

Journal

Biochim Biophys Acta 99:397-405 (1965)

Reference

3 [PMID:14430183]

Authors

PANT R.

Title

Isolation of lombricine and its enzymic phosphorylation.

Journal

Biochem J 73:30-3 (1959)
DOI:10.1042/bj0730030

Reference

4 [PMID:5079888]

Authors

van Thoai N, Robin Y, Guillou Y.

Title

A new phosphagen, N'-phosphorylguanidinoethylphospho-O-( -N,N-dimethyl)serine (phosphothalassemine).

Journal

Biochemistry 11:3890-5 (1972)
DOI:10.1021/bi00771a009

Other DBs

ExplorEnz - The Enzyme Database:

2.7.3.5

IUBMB Enzyme Nomenclature:

2.7.3.5

ExPASy - ENZYME nomenclature database:

2.7.3.5

BRENDA, the Enzyme Database:

2.7.3.5

CAS:

9026-53-3

LinkDB

REACTION: R03691

Entry

R03691                      Reaction

Name

ATP:lombricine N-phosphotransferase

Definition

ATP + D-Lombricine <=> ADP + N-Phospho-D-lombricine

Equation

C00002 + C01726 <=> C00008 + C02855

Reaction class

RC00002

C00002_C00008

RC00203

C01726_C02855

Enzyme

2.7.3.5

Pathway

rn00470

D-Amino acid metabolism

rn01100

Metabolic pathways

Orthology

K25364

lombricine kinase [EC:2.7.3.5]

LinkDB

DBGET integrated database retrieval system