KEGG   ORTHOLOGY: K25364
Entry
K25364                      KO                                     
Symbol
LK
Name
lombricine kinase [EC:2.7.3.5]
Pathway
map00470  D-Amino acid metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00470 D-Amino acid metabolism
    K25364  LK; lombricine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.3  Phosphotransferases with a nitrogenous group as acceptor
    2.7.3.5  lombricine kinase
     K25364  LK; lombricine kinase
Other DBs
RN: R03691
GO: 0050059
Genes
AG: AAM10823 BAA22872
Reference
PMID:9434106
  Authors
Suzuki T, Kawasaki Y, Furukohri T, Ellington WR
  Title
Evolution of phosphagen kinase. VI. Isolation, characterization and cDNA-derived amino acid sequence of lombricine kinase from the earthworm Eisenia foetida, and  identification of a possible candidate for the guanidine substrate recognition site.
  Journal
Biochim Biophys Acta 1343:152-9 (1997)
DOI:10.1016/s0167-4838(97)00128-3
  Sequence
Reference
  Authors
Ellington WR, Bush J
  Title
Cloning and expression of a lombricine kinase from an echiuroid worm: insights into structural correlates of substrate specificity.
  Journal
Biochem Biophys Res Commun 291:939-44 (2002)
DOI:10.1006/bbrc.2002.6539
  Sequence
LinkDB

KEGG   ENZYME: 2.7.3.5
Entry
EC 2.7.3.5                  Enzyme                                 
Name
lombricine kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a nitrogenous group as acceptor
Sysname
ATP:lombricine N-phosphotransferase
Reaction(IUBMB)
ATP + lombricine = ADP + N-phospholombricine [RN:R06976]
Reaction(KEGG)
R06976;
(other) R03691
Substrate
ATP [CPD:C00002];
lombricine [CPD:C14177]
Product
ADP [CPD:C00008];
N-phospholombricine [CPD:C14178]
Comment
Also acts on methylated lombricines such as thalassemine; the specificity varies with the source species.
History
EC 2.7.3.5 created 1965, modified 1976
Pathway
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K25364  lombricine kinase
Reference
1  [PMID:5832288]
  Authors
Gaffney TJ, Rosenberg H, Ennor AH.
  Title
The purification and properties of adenosine triphosphate-lombricine phosphotransferase.
  Journal
Biochem J 90:170-6 (1964)
DOI:10.1042/bj0900170
Reference
2  [PMID:5840960]
  Authors
Kassab R, Pradel LA, Nguyen Van Thoai.
  Title
[ATP:taurocyamine and ATP:lombricine phosphotransferases. Purification and study of SH groups]
  Journal
Biochim Biophys Acta 99:397-405 (1965)
Reference
3  [PMID:14430183]
  Authors
PANT R.
  Title
Isolation of lombricine and its enzymic phosphorylation.
  Journal
Biochem J 73:30-3 (1959)
DOI:10.1042/bj0730030
Reference
4  [PMID:5079888]
  Authors
van Thoai N, Robin Y, Guillou Y.
  Title
A new phosphagen, N'-phosphorylguanidinoethylphospho-O-( -N,N-dimethyl)serine (phosphothalassemine).
  Journal
Biochemistry 11:3890-5 (1972)
DOI:10.1021/bi00771a009
Other DBs
ExplorEnz - The Enzyme Database: 2.7.3.5
IUBMB Enzyme Nomenclature: 2.7.3.5
ExPASy - ENZYME nomenclature database: 2.7.3.5
BRENDA, the Enzyme Database: 2.7.3.5
CAS: 9026-53-3
LinkDB

KEGG   REACTION: R03691
Entry
R03691                      Reaction                               
Name
ATP:lombricine N-phosphotransferase
Definition
ATP + D-Lombricine <=> ADP + N-Phospho-D-lombricine
Equation
Reaction class
RC00002  C00002_C00008
RC00203  C01726_C02855
Enzyme
Pathway
rn00470  D-Amino acid metabolism
rn01100  Metabolic pathways
Orthology
K25364  lombricine kinase [EC:2.7.3.5]
LinkDB

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