KEGG   ORTHOLOGY: K25517
Entry
K25517                      KO                                     
Symbol
acnX1
Name
phosphomecalonate degydratase large subunit [EC:4.2.1.182]
Pathway
map00900  Terpenoid backbone biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Reaction
R12894  R-5-phosphomevalonate hydro-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K25517  acnX1; phosphomecalonate degydratase large subunit
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.182  phosphomevalonate dehydratase
     K25517  acnX1; phosphomecalonate degydratase large subunit
Other DBs
COG: COG1786
Genes
AGAT: RWV98_05430
BCOC: BLCOC_22840 BLCOC_22860 BLCOC_31080
CHYL: CE91St63_25960
ACTY: OG774_04220
MJA: MJ_1313
MFE: Mefer_1421
MVU: Metvu_1202
MFS: MFS40622_0378
MIF: Metin_0709
MJH: JH146_0315
MMP: MMP1663
MMD: GYY_09170
MMAD: MMJJ_11690
MAE: Maeo_1036
MVO: Mvol_1301
MTH: MTH_1421
MTEE: MTTB_00060
METC: MTCT_1292
METE: tca_01372
MST: Msp_0008
MRU: mru_2095
MSI: Msm_1192
MEB: Abm4_0086
MMIL: sm9_0097
MEYE: TL18_10225
MOL: YLM1_1724
METH: MBMB1_2037
MFC: BRM9_0006
MCUB: MCBB_2333
MFV: Mfer_0905
MKA: MK1639
AFU: AF_2333
FPL: Ferp_0108
GAC: GACE_1779
GAH: GAH_00857
PFU: PF0390
PFI: PFC_01030
PHO: PH0354(PH0354)
PAB: PAB1061
PYN: PNA2_0963
PYS: Py04_0662
TKO: TK1249
TON: TON_0514
TGA: TGAM_1120(acnX)
TSI: TSIB_1944
THE: GQS_02585
THA: TAM4_2182
THM: CL1_0165
TLT: OCC_10324
THS: TES1_0899
TNU: BD01_0421
TEU: TEU_08605
PPAC: PAP_03700
MBAR: MSBR2_2053
MBAK: MSBR3_2122
MAC: MA_0245
MMA: MM_1525
MMAC: MSMAC_3162
METM: MSMTP_3040
MTHR: MSTHT_2040
MTHE: MSTHC_1246
MHOR: MSHOH_3879
MBU: Mbur_1472
MMET: MCMEM_1972
MMH: Mmah_1772
MPY: Mpsy_2252
MTP: Mthe_0207
MCJ: MCON_2874
MHI: Mhar_1472
MHU: Mhun_2437
MLA: Mlab_0056
MEMA: MMAB1_1715
MPI: Mpet_1883
MAQE: RJ40_06745
MBN: Mboo_0123
MPL: Mpal_0511
MPD: MCP_2308
MEZ: Mtc_1231
RCI: LRC243
HALH: HTSR_1040
HHSR: HSR6_1073
HAHS: HSRCO_1216
HUT: Huta_0616
HTI: HTIA_0364
HASV: SVXHr_1978
MARC: AR505_0453
ABI: Aboo_0849
ACJ: ACAM_1307
SMR: Smar_0622
IHO: Igni_0695
IIS: EYM_07510
IPC: IPA_09455
DKA: DKAM_0143
TAG: Tagg_1155
IAG: Igag_1938
HBU: Hbut_1634
PABI: PABY_02550
PARE: PYJP_14520
PAI: PAE2233
PIS: Pisl_0855
PCL: Pcal_0949
PAS: Pars_1920
PYR: P186_0458
POG: Pogu_0207
TNE: Tneu_1398
CMA: Cmaq_0991
TTN: TTX_1590
TUZ: TUZN_1948
VDI: Vdis_1832
VMO: VMUT_0272
TPE: Tpen_0796
ASC: ASAC_0164
ACIA: SE86_01580
NMR: Nmar_0053
NCT: NMSP_0055
NEV: NTE_02684
NCV: NCAV_0094
NBV: T478_0049
NDV: NDEV_0071
CCAI: NAS2_0339
KCR: Kcr_1257
BARC: AOA65_2274
 » show all
Reference
  Authors
Hayakawa H, Motoyama K, Sobue F, Ito T, Kawaide H, Yoshimura T, Hemmi H.
  Title
Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate.
  Journal
Proc Natl Acad Sci U S A 115:10034-10039 (2018)
DOI:10.1073/pnas.1809154115
  Sequence
Reference
  Authors
Yoshida R, Yoshimura T, Hemmi H.
  Title
Reconstruction of the "Archaeal" Mevalonate Pathway from the Methanogenic Archaeon Methanosarcina mazei in Escherichia coli Cells.
  Journal
Appl Environ Microbiol 86:AEM.02889-19 (2020)
DOI:10.1128/AEM.02889-19
  Sequence
[mma:MM_1525]
LinkDB

KEGG   ORTHOLOGY: K09128
Entry
K09128                      KO                                     
Symbol
acnX2
Name
phosphomecalonate degydratase small subunit [EC:4.2.1.182]
Pathway
map00900  Terpenoid backbone biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Reaction
R12894  R-5-phosphomevalonate hydro-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K09128  acnX2; phosphomecalonate degydratase small subunit
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.182  phosphomevalonate dehydratase
     K09128  acnX2; phosphomecalonate degydratase small subunit
Other DBs
COG: COG1786
Genes
ANJ: AMD1_0009
PNW: SYK_15530
DEK: DSLASN_10080
AGAT: RWV98_01370 RWV98_05425
BCOC: BLCOC_22850 BLCOC_22870 BLCOC_31070 BLCOC_43200
BHV: BLHYD_07890
CHYL: CE91St63_25950
ETM: CE91St48_33550
ACIR: OG979_31240
ARHD: VSH64_03830 VSH64_05035
MJA: MJ_1407
MMP: MMP0902
MMD: GYY_05225
MMAD: MMJJ_00900
MAE: Maeo_0452
MVO: Mvol_0933
MTH: MTH_1530
MTEE: MTTB_15270
METC: MTCT_1393
METE: tca_01478
MST: Msp_0225
MRU: mru_0202
MSI: Msm_1155
MEB: Abm4_0127
MMIL: sm9_0159
MEYE: TL18_10020
MOL: YLM1_1820
METH: MBMB1_0075
MFC: BRM9_0139
MCUB: MCBB_0100
MFV: Mfer_0495
MKA: MK1486
AFU: AF_0055
FPL: Ferp_0107
GAC: GACE_1778
GAH: GAH_00858
PFU: PF0391
PFI: PFC_01035
PHO: PH0353(PH0353)
PAB: PAB1062
PYN: PNA2_0962
PYS: Py04_0661
TKO: TK1248
TON: TON_0513
TGA: TGAM_1119(acnX)
TSI: TSIB_1943
THE: GQS_02590
THA: TAM4_1938
THM: CL1_0166
TLT: OCC_10319
THS: TES1_0898
TNU: BD01_0420
TEU: TEU_08600
PPAC: PAP_03695
MBAR: MSBR2_2054
MBAK: MSBR3_2123
MAC: MA_0244
MMA: MM_1524
MMAC: MSMAC_3163
METM: MSMTP_3041
MTHR: MSTHT_2041
MTHE: MSTHC_1245
MHOR: MSHOH_3880
MBU: Mbur_1471
MMET: MCMEM_1971
MMH: Mmah_1771
MPY: Mpsy_2251
MTP: Mthe_0208
MCJ: MCON_2875
MHI: Mhar_1471
MHU: Mhun_1041
MLA: Mlab_0800
MEMA: MMAB1_2659
MPI: Mpet_2083
MAQE: RJ40_12530
MBN: Mboo_1457
MPL: Mpal_0506
MPD: MCP_2309
MEZ: Mtc_1230
RCI: LRC241
HALH: HTSR_1041
HHSR: HSR6_1074
HAHS: HSRCO_1217
HUT: Huta_0615
HTI: HTIA_0363
HASV: SVXHr_1979
MELU: MTLP_11110
MEAR: Mpt1_c03830(nudI)
MARC: AR505_0454
ABI: Aboo_0848
APE: APE_2089
ACJ: ACAM_1308
SMR: Smar_0623
IHO: Igni_0694
IIS: EYM_07505
IPC: IPA_09450
DKA: DKAM_0142
TAG: Tagg_1154
IAG: Igag_1937
HBU: Hbut_1633
PABI: PABY_02540
PARE: PYJP_14510
PAI: PAE2234
PIS: Pisl_0854
PCL: Pcal_0950
PAS: Pars_1919
PYR: P186_0459
POG: Pogu_0208
TNE: Tneu_1399
CMA: Cmaq_1865
TTN: TTX_1589
TUZ: TUZN_1949
VDI: Vdis_2182
VMO: VMUT_0577
TPE: Tpen_0797
ASC: ASAC_0163
ACIA: SE86_01575
NMR: Nmar_0054
NCT: NMSP_0056
NEV: NTE_02685
NCV: NCAV_0093
NBV: T478_0051
NDV: NDEV_0072
CCAI: NAS2_1614
BARC: AOA65_2273
BARB: AOA66_0499
 » show all
Reference
  Authors
Hayakawa H, Motoyama K, Sobue F, Ito T, Kawaide H, Yoshimura T, Hemmi H.
  Title
Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate.
  Journal
Proc Natl Acad Sci U S A 115:10034-10039 (2018)
DOI:10.1073/pnas.1809154115
  Sequence
[ape:APE_2089]
Reference
  Authors
Yoshida R, Yoshimura T, Hemmi H.
  Title
Reconstruction of the "Archaeal" Mevalonate Pathway from the Methanogenic Archaeon Methanosarcina mazei in Escherichia coli Cells.
  Journal
Appl Environ Microbiol 86:AEM.02889-19 (2020)
DOI:10.1128/AEM.02889-19
  Sequence
[mma:MM_1524]
LinkDB

KEGG   REACTION: R12894
Entry
R12894                      Reaction                               
Name
R-5-phosphomevalonate hydro-lyase
Definition
(R)-5-Phosphomevalonate <=> trans-Anhydromevalonate phosphate + H2O
Equation
Comment
mevalonate 5-phosphate dehydratase
Reaction class
RC03563  C01107_C22453
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.182
     R12894  (R)-5-Phosphomevalonate <=> trans-Anhydromevalonate phosphate + H2O
Orthology
K09128  phosphomecalonate degydratase small subunit [EC:4.2.1.182]
K25517  phosphomecalonate degydratase large subunit [EC:4.2.1.182]
LinkDB

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