KEGG ORTHOLOGY: K25517

ORTHOLOGY: K25517

Entry

K25517                      KO

Symbol

acnX1

Name

phosphomecalonate degydratase large subunit [EC:4.2.1.182]

Pathway

map00900

Terpenoid backbone biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00849

C5 isoprenoid biosynthesis, mevalonate pathway, archaea

Reaction

R12894

(R)-5-phosphomevalonate hydro-lyase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K25517  acnX1; phosphomecalonate degydratase large subunit
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.182  phosphomevalonate dehydratase
     K25517  acnX1; phosphomecalonate degydratase large subunit

Other DBs

COG:

COG1786

Genes

VAZ:	H7F35_34255

AGAT:

RWV98_05430

CHYL:

CE91St63_25960

MJA:

MJ_1313

MFE:	Mefer_1421

MVU:	Metvu_1202

MFS:	MFS40622_0378

MIF:	Metin_0709

MJH:	JH146_0315

MESG:

MLAUSG7_1120

MESA:

MLASG1_0655

MIG:	Metig_1406

MMP:

MMP1663

MMQ:	MmarC5_1745

MMX:	MmarC6_1010

MMZ:	MmarC7_0935

MMD:

MMAK:

MMAO:

MMAD:

MAE:

MVN:	Mevan_0963

MVO:

Mvol_1301

MOK:	Metok_0993

METF:

CFE53_03445

MTH:

MTH_1421

MMG:	MTBMA_c00090

MWO:	MWSIV6_1799

MTEE:

METC:

METE:

METZ:

METK:

MTHM:

METJ:

MST:

METB:

MEIS:

MRU:

MSI:

MEB:

MMIL:

MEYE:

MOL:

MARO:

METV:

MEL:	Metbo_0105

MEW:	MSWAN_2414

METH:

MBMB1_2037

MFC:

BRM9_0006

MFI:	DSM1535_1324

MCUB:

MSUB:

METN:

METT:

METO:

MEME:

MFEG:

MFV:

MKA:

AFU:

AFG:	AFULGI_00026330

APO:	Arcpr_1395

AVE:	Arcve_0619

AST:	Asulf_00994

FPL:

GAC:

GAH:

PFU:

PFI:

PHO:	PH0354(PH0354)

PAB:

PAB1061

PYN:

PNA2_0963

PYA:	PYCH_13830

PYS:

Py04_0662

PYC:	TQ32_03560

TKO:

TK1249

TON:

TON_0514

TGA:	TGAM_1120(acnX)

TSI:

TSIB_1944

TBA:	TERMP_00893

THE:

THA:

THM:

TLT:

THS:

TNU:

TEU:

TGY:	X802_08765

THV:	ADU37_CDS20790

TCH:	CHITON_1181

TPEP:

A0127_08680

TPIE:

A7C91_08620

TGG:	A3K92_05205

TCE:	A3L02_02475

TBS:	A3L01_03305

THH:	CDI07_03240

TSL:	A3L11_07280

TTD:	A3L14_04990

TPRF:

A3L09_07630

TRL:	A3L10_03265

TPAF:

A3L08_06360

THY:	A3L12_05565

TIC:	FH039_05855

TCQ:	TIRI35C_0895

THEM:

FPV09_03495

THEI:

K1720_02460

PPAC:

PAP_03700

MBA:	Mbar_A0717

MBY:	MSBRM_0328

MBW:	MSBRW_0284

MBAR:

MBAK:

MAC:

MMA:

MMAZ:

MMJ:	MSMAS_3142

MMAC:

MSMAC_3162

MVC:	MSVAZ_0316

MEK:	MSKOL_0300

MLS:	MSLAZ_0092

METM:

MSMTP_3040

MEF:	MSWH1_0172

MEQ:	MSWHS_0171

MSJ:	MSSAC_0231

MSZ:	MSSIH_0200

MSW:	MSSIT_0204

MTHR:

MSTHT_2040

MTHE:

MSTHC_1246

MHOR:

MSHOH_3879

MFZ:	AOB57_009515

MBU:

MMET:

MELO:

MMH:

MHAZ:

MPOT:

MEV:	Metev_2055

MZH:	Mzhil_1540

MPY:

Mpsy_2252

MZI:	HWN40_10875

MMAV:

RE476_12225

MSEB:

RE474_09115

MHZ:	Metho_2163

MEHF:

MEES:

MTP:

MCJ:

MHI:

MHU:

MRTJ:

MLA:

MEM:	Memar_2138

MBG:	BN140_1346

MEMA:

MMAB1_1715

MCHK:

MchiMG62_24470

MSUM:

OH143_04975

MRC:	R6Y96_01585

MPI:

MEND:

MEFW:

MAQE:

MFK:	E2N92_06910

MOU:	OU421_09620

MESB:

L1S32_00815

MANQ:

L1994_03865

MBN:

Mboo_0123

MFO:	Metfor_0251

MPL:

MPD:

MEZ:

RCI:

MJK:	N2V74_02220 N2V74_03640

HALH:

HTSR_1040

HHSR:

HSR6_1073

HSU:	HLASF_0830

HSF:	HLASA_0827

HAHS:

HUT:

HTI:

HALA:

HASV:

HABN:

HDS:	HSR122_0651

HARC:

HARCEL1_02635

HDF:	AArcSl_1771

HAAA:

AArcCO_0145

MEAM:

MU439_04165

MEAE:

QEN48_05815

TAR:	TALC_00511

MAX:	MMALV_04600

MER:	MMINT_07310

MEAR:

MEUZ:

MARC:

ABI:

ACF:	AciM339_0156

APE:	APE_2087.1

ACJ:

ACAM_1307

SMR:

Smar_0622

SHC:	Shell_0173

IHO:

IIS:

IPC:

DKA:

DFD:	Desfe_0218

DMU:	Desmu_0694

TAG:

Tagg_1155

IAG:

Igag_1938

THG:	TCELL_0123

HBU:

Hbut_1634

PFM:	Pyrfu_0193

PDL:	Pyrde_0503

PABI:

PARE:

PAI:

PIS:

PCL:

PAS:

PYR:

POG:

TNE:

PYW:	PYWP30_01479

CMA:

TTN:

TUZ:

VDI:

VMO:

TPE:

THB:	N186_05495

TCB:	TCARB_0166

THF:	MA03_05625

THEL:

IG193_03590

ASC:

ASAC_0164

ACIA:

SE86_01580

CLG:	Calag_0819

FFO:	FFONT_1070

NMR:

Nmar_0053

NIR:	NSED_09895

NKR:	NKOR_00045

NID:	NPIRD3C_0317

NIN:	NADRNF5_0014

NIW:	Nisw_04725

NCL:	C5F47_00265

NOX:	C5F49_00265

NIP:	NsoK4_08935

NZT:	NZOSNM25_002058

NCT:

NMSP_0055

NIC:	DSQ20_00310

NGA:	Ngar_c08140

NVN:	NVIE_012770

NEV:

NTE_02684

TAA:	NMY3_03541

NFN:	NFRAN_0895

NCV:

NCAV_0094

CSY:	CENSYa_1907

NBV:

T478_0049

TAH:	SU86_006495

NIU:	DSQ19_10215

NCK:	QVH35_02950

NDV:

CCAI:

KCR:

BARC:

FLT:	Sv326_0059

LOKI:

Lokiarch_22740

» show all

Reference

PMID:30224495

Authors

Hayakawa H, Motoyama K, Sobue F, Ito T, Kawaide H, Yoshimura T, Hemmi H.

Title

Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate.

Journal

Proc Natl Acad Sci U S A 115:10034-10039 (2018)
DOI:10.1073/pnas.1809154115

Sequence

[ape:APE_2087.1]

Reference

PMID:31924615

Authors

Yoshida R, Yoshimura T, Hemmi H.

Title

Reconstruction of the "Archaeal" Mevalonate Pathway from the Methanogenic Archaeon Methanosarcina mazei in Escherichia coli Cells.

Journal

Appl Environ Microbiol 86:AEM.02889-19 (2020)
DOI:10.1128/AEM.02889-19

Sequence

[mma:MM_1525]

LinkDB

ORTHOLOGY: K09128

Entry

K09128                      KO

Symbol

acnX2

Name

phosphomecalonate degydratase small subunit [EC:4.2.1.182]

Pathway

map00900

Terpenoid backbone biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00849

C5 isoprenoid biosynthesis, mevalonate pathway, archaea

Reaction

R12894

(R)-5-phosphomevalonate hydro-lyase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K09128  acnX2; phosphomecalonate degydratase small subunit
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.182  phosphomevalonate dehydratase
     K09128  acnX2; phosphomecalonate degydratase small subunit

Other DBs

COG:

COG1786

Genes

MAER:

DAI18_17280

VAZ:	H7F35_34250

BRUC:

LJ361_00030

PNW:

SYK_15530

DEK:	DSLASN_10080

AGAT:

RWV98_01370 RWV98_05425

BHV:	BLHYD_07890

CHYL:

CE91St63_25950

ETM:	CE91St48_33550

MHAW:

RMN56_28590

LUB:	TBR22_A12610

MJA:

MJ_1407

MFE:	Mefer_0080

MVU:	Metvu_1439

MFS:	MFS40622_0336

MIF:	Metin_0203

MJH:	JH146_0335

MESG:

MLAUSG7_1129

MESA:

MLASG1_0646

MIG:	Metig_1502

MMP:

MMP0902

MMQ:	MmarC5_0709

MMX:	MmarC6_1754

MMZ:	MmarC7_0149

MMD:

MMAK:

MMAO:

MMAD:

MAE:

MVN:	Mevan_0019

MVO:

Mvol_0933

MOK:	Metok_0423

METF:

CFE53_03920

MTH:

MTH_1530

MMG:	MTBMA_c01130

MWO:	MWSIV6_0069

MTEE:

METC:

METE:

METZ:

METK:

MTHM:

METJ:

MST:

METB:

MEIS:

MRU:

MSI:

MEB:

MMIL:

MEYE:

MOL:

MARO:

METV:

MEL:	Metbo_0003

MEW:	MSWAN_0095

METH:

MBMB1_0075

MFC:

BRM9_0139

MFI:	DSM1535_1462

MCUB:

MSUB:

METN:

METT:

METO:

MEME:

MFEG:

MFV:

MKA:

AFU:

AFG:	AFULGI_00000480

APO:	Arcpr_0690

AVE:	Arcve_1712

AST:	Asulf_00141

FPL:

GAC:

GAH:

PFU:

PFI:

PHO:	PH0353(PH0353)

PAB:

PAB1062

PYN:

PNA2_0962

PYA:	PYCH_13840

PYS:

Py04_0661

PYC:	TQ32_03565

TKO:

TK1248

TON:

TON_0513

TGA:	TGAM_1119(acnX)

TSI:

TSIB_1943

TBA:	TERMP_00892

THE:

THA:

THM:

TLT:

THS:

TNU:

TEU:

TGY:	X802_08770

THV:	ADU37_CDS20780

TCH:	CHITON_1180

TPEP:

A0127_08685

TPIE:

A7C91_08615

TGG:	A3K92_05210

TCE:	A3L02_02480

TBS:	A3L01_03300

THH:	CDI07_03235

TSL:	A3L11_07275

TTD:	A3L14_04985

TPRF:

A3L09_07635

TRL:	A3L10_03270

TPAF:

A3L08_06355

THY:	A3L12_05570

TIC:	FH039_05850

TCQ:	TIRI35C_0894

THEM:

FPV09_03500

THEI:

K1720_02455

PPAC:

PAP_03695

MBA:	Mbar_A0718

MBY:	MSBRM_0327

MBW:	MSBRW_0283

MBAR:

MBAK:

MAC:

MMA:

MMAZ:

MMJ:	MSMAS_3143

MMAC:

MSMAC_3163

MVC:	MSVAZ_0317

MEK:	MSKOL_0301

MLS:	MSLAZ_0093

METM:

MSMTP_3041

MEF:	MSWH1_0171

MEQ:	MSWHS_0170

MSJ:	MSSAC_0230

MSZ:	MSSIH_0199

MSW:	MSSIT_0203

MTHR:

MSTHT_2041

MTHE:

MSTHC_1245

MHOR:

MSHOH_3880

MFZ:	AOB57_009520

MBU:

MMET:

MELO:

MMH:

MHAZ:

MPOT:

MEV:	Metev_2054

MZH:	Mzhil_1539

MPY:

Mpsy_2251

MZI:	HWN40_10880

MMAV:

RE476_12220

MSEB:

RE474_09110

MHZ:	Metho_2164

MEHF:

MEES:

MTP:

MCJ:

MHI:

MHU:

MRTJ:

MLA:

MEM:	Memar_1309

MBG:	BN140_2051

MEMA:

MMAB1_2659

MCHK:

MchiMG62_14940

MSUM:

OH143_00780

MRC:	R6Y96_07365

MPI:

MEND:

MEFW:

MAQE:

MFK:	E2N92_00350

MOU:	OU421_11465

MESB:

L1S32_03355

MANQ:

L1994_07210

MBN:

Mboo_1457

MFO:	Metfor_1534

MPL:

MPD:

MEZ:

RCI:

MJK:	N2V74_00140 N2V74_05710

HALH:

HTSR_1041

HHSR:

HSR6_1074

HSU:	HLASF_0831

HSF:	HLASA_0828

HAHS:

HUT:

HTI:

HALA:

HASV:

HABN:

HDS:	HSR122_0650

HARC:

HARCEL1_02640

HDF:	AArcSl_1772

HAAA:

MELU:

MEAM:

MEAE:

TAR:	TALC_00512

MAX:	MMALV_04610

MER:	MMINT_07320

MEAR:

Mpt1_c03830(nudI)

MEUZ:

KRP56_05840

MARC:

AR505_0454

ABI:

Aboo_0848

ACF:	AciM339_0157

APE:

APE_2089

ACJ:

ACAM_1308

SMR:

Smar_0623

SHC:	Shell_0172

IHO:

IIS:

IPC:

DKA:

DFD:	Desfe_0217

DMU:	Desmu_0693

TAG:

Tagg_1154

IAG:

Igag_1937

THG:	TCELL_0122

HBU:

Hbut_1633

PFM:	Pyrfu_0194

PDL:	Pyrde_0502

PABI:

PARE:

PAI:

PIS:

PCL:

PAS:

PYR:

POG:

TNE:

PYW:	PYWP30_01480

CMA:

TTN:

TUZ:

VDI:

VMO:

VSO:	Vsou_22030

TPE:

Tpen_0797

THB:	N186_05490

TCB:	TCARB_0165

THF:	MA03_05620

THEL:

IG193_03585

ASC:

ASAC_0163

ACIA:

SE86_01575

CLG:	Calag_0818

FFO:	FFONT_1071

NMR:

Nmar_0054

NIR:	NSED_09900

NKR:	NKOR_00040

NID:	NPIRD3C_0318

NIN:	NADRNF5_0013

NIW:	Nisw_04720

NCL:	C5F47_00270

NOX:	C5F49_00260

NUE:	C5F50_00270

NIP:	NsoK4_08930

NZT:	NZOSNM25_002057

NCT:

NMSP_0056

NIC:	DSQ20_00305

NGA:	Ngar_c08150

NVN:	NVIE_012780

NEV:

NTE_02685

TAA:	NMY3_03542

NFN:	NFRAN_0896

NCV:

NCAV_0093

CSY:	CENSYa_1908

NBV:

T478_0051

TAH:	SU86_006500

NIU:	DSQ19_10210

NCK:	QVH35_02940

NDV:

CCAI:

BARC:

BARB:

FLT:	Sv326_0060

LOKI:

Lokiarch_22750

» show all

Reference

PMID:30224495

Authors

Hayakawa H, Motoyama K, Sobue F, Ito T, Kawaide H, Yoshimura T, Hemmi H.

Title

Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate.

Journal

Proc Natl Acad Sci U S A 115:10034-10039 (2018)
DOI:10.1073/pnas.1809154115

Sequence

[ape:APE_2089]

Reference

PMID:31924615

Authors

Yoshida R, Yoshimura T, Hemmi H.

Title

Reconstruction of the "Archaeal" Mevalonate Pathway from the Methanogenic Archaeon Methanosarcina mazei in Escherichia coli Cells.

Journal

Appl Environ Microbiol 86:AEM.02889-19 (2020)
DOI:10.1128/AEM.02889-19

Sequence

[mma:MM_1524]

LinkDB

REACTION: R12894

Entry

R12894                      Reaction

Name

(R)-5-phosphomevalonate hydro-lyase

Definition

(R)-5-Phosphomevalonate <=> trans-Anhydromevalonate 5-phosphate + H2O

Equation

C01107 <=> C22453 + C00001

Comment

mevalonate 5-phosphate dehydratase

Reaction class

RC03563

C01107_C22453

Enzyme

4.2.1.182

Pathway

rn00900

Terpenoid backbone biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00849

C5 isoprenoid biosynthesis, mevalonate pathway, archaea

Brite

Enzymatic reactions [BR:br08201]
4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.182
     R12894  (R)-5-Phosphomevalonate <=> trans-Anhydromevalonate 5-phosphate + H2O

Orthology

K09128

phosphomecalonate degydratase small subunit [EC:4.2.1.182]

K25517

phosphomecalonate degydratase large subunit [EC:4.2.1.182]

Reference

1 [PMID:30224495]

Authors

Hayakawa H, Motoyama K, Sobue F, Ito T, Kawaide H, Yoshimura T, Hemmi H.

Title

Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate.

Journal

Proc Natl Acad Sci U S A 115:10034-10039 (2018)
DOI:10.1073/pnas.1809154115

LinkDB

DBGET integrated database retrieval system