KEGG ORTHOLOGY: K25743

ORTHOLOGY: K25743

Entry

K25743                      KO

Symbol

TWSG1

Name

twisted gastrulation protein 1

Brite

KEGG Orthology (KO) [BR:ko00001]
09190 Not Included in Pathway or Brite
  09193 Unclassified: signaling and cellular processes
   99995 Signaling proteins
    K25743  TWSG1; twisted gastrulation protein 1

Other DBs

GO:	0050431 0036122

Genes

HSA:	57045(TWSG1)

PTR:	455294(TWSG1)

PPS:	100986826(TWSG1)

GGO:	101148429(TWSG1)

PON:	100172557(TWSG1)

NLE:	100600360(TWSG1)

HMH:	116468741(TWSG1)

MCC:	705804(TWSG1)

MCF:	101926712(TWSG1)

MTHB:

126941131

MNI:	105478883(TWSG1)

CSAB:

103222755(TWSG1)

CATY:

105579319(TWSG1)

PANU:

100998371(TWSG1)

TGE:	112611531(TWSG1)

MLEU:

105542374(TWSG1)

RRO:	104670234(TWSG1)

RBB:	108523926(TWSG1)

TFN:	117064145(TWSG1)

PTEH:

111553590(TWSG1)

CANG:

105507896(TWSG1)

CJC:	100391150(TWSG1)

SBQ:	101045333(TWSG1)

CIMI:

108314837(TWSG1)

CSYR:

103254006(TWSG1)

MMUR:

105861021(TWSG1)

LCAT:

123621507(TWSG1)

PCOQ:

105813612(TWSG1)

OGA:	100945320(TWSG1)

MMU:	65960(Twsg1)

MCAL:

110312154(Twsg1)

MPAH:

110335555(Twsg1)

RNO:	363294(Twsg1)

MCOC:

116088855(Twsg1)

ANU:	117693480(Twsg1)

MUN:	110558557(Twsg1)

CGE:	100755780(Twsg1)

MAUA:

101825679(Twsg1)

PROB:

127226766(Twsg1)

PLEU:

114696318(Twsg1)

MORG:

121433444(Twsg1)

MFOT:

126508306

AAMP:

119821496(Twsg1)

NGI:	103735423(Twsg1)

HGL:	101712397(Twsg1)

CPOC:

100718461(Twsg1)

CCAN:

109685367(Twsg1)

DORD:

106001294(Twsg1)

DSP:	122110981(Twsg1)

PLOP:

125364039(Twsg1)

NCAR:

124965813

MMMA:

107159449(Twsg1)

OCU:

100357224

OPI:	101521679(TWSG1)

TUP:	102470550(TWSG1)

GVR:	103590486(TWSG1)

CFA:	490546(TWSG1)

CLUD:

112648060(TWSG1)

VVP:	112925283(TWSG1)

VLG:	121500275(TWSG1)

NPO:	129509116(TWSG1)

AML:	100466079(TWSG1)

UMR:	103662395(TWSG1)

UAH:	113253218(TWSG1)

UAR:	123789912(TWSG1)

ELK:

111142519

LLV:

125082377

MPUF:

101693252(TWSG1)

MNP:	132023478(TWSG1)

MLK:	131810890(TWSG1)

NVS:	122903034(TWSG1)

ORO:	101380060(TWSG1)

EJU:	114224721(TWSG1)

ZCA:	113912864(TWSG1)

MLX:	118016433(TWSG1)

NSU:	110579811(TWSG1)

LWW:	102741210(TWSG1)

FCA:	101101257(TWSG1)

PYU:	121032736(TWSG1)

PCOO:

112868375(TWSG1)

PBG:	122470562(TWSG1)

PVIV:

125149602(TWSG1)

LRUF:

124519867

PTG:	102967125(TWSG1)

PPAD:

109248636(TWSG1)

PUC:

125914818

AJU:

106965542

HHV:	120221589(TWSG1)

BTA:	537290(TWSG1)

BOM:	102275405(TWSG1)

BIU:	109577878(TWSG1)

BBUB:

102390239(TWSG1)

BBIS:

105002461(TWSG1)

CHX:	102174451(TWSG1)

OAS:	101107404(TWSG1)

BTAX:

128067470(TWSG1)

ODA:	120881068(TWSG1)

CCAD:

122425645(TWSG1)

MBEZ:

129549786(TWSG1)

SSC:	100519317(TWSG1)

CFR:	102523172(TWSG1)

CBAI:

105071427(TWSG1)

CDK:	105086488(TWSG1)

VPC:	102532056(TWSG1)

BACU:

103019835(TWSG1)

BMUS:

118880211(TWSG1)

LVE:	103076918(TWSG1)

OOR:	101275359(TWSG1)

DLE:	111162979(TWSG1)

PCAD:

102994542(TWSG1)

PSIU:

116739133(TWSG1)

NASI:

112412288(TWSG1)

ECB:	100054712(TWSG1)

EPZ:

103541496

EAI:	106825959 106828657(TWSG1)

MYB:	102261480(TWSG1)

MYD:	102761778(TWSG1)

MMYO:

118662878(TWSG1)

MLF:	102424806(TWSG1)

PKL:	118707769(TWSG1)

EFUS:

103302765(TWSG1)

MNA:	107533985(TWSG1)

DRO:	112322743(TWSG1)

SHON:

118989986(TWSG1)

AJM:	119040960(TWSG1)

PDIC:

114506595(TWSG1)

PHAS:

123826396(TWSG1)

MMF:	118619013(TWSG1)

PPAM:

129081679(TWSG1)

HAI:	109386634(TWSG1)

RFQ:	117011890(TWSG1)

PALE:

102890263(TWSG1)

PGIG:

120588625(TWSG1)

PVP:	105296189(TWSG1)

RAY:	107498175(TWSG1)

MJV:	108401490(TWSG1)

TOD:	119243190(TWSG1)

SARA:

101559240(TWSG1)

SETR:

126003791(TWSG1)

LAV:	100664910(TWSG1)

TMU:

101344982

ETF:	101648915(TWSG1)

DNM:	101441020(TWSG1)

MDO:	100013165(TWSG1)

GAS:	123254058(TWSG1)

SHR:	100921058(TWSG1)

AFZ:

127544024

PCW:	110207773(TWSG1)

OAA:	100081432(TWSG1)

GGA:	374024(TWSG1)

PCOC:

116226201(TWSG1)

MGP:	100549818(TWSG1)

CJO:	107310017(TWSG1)

TPAI:

128090938(TWSG1)

LMUT:

125690354(TWSG1)

NMEL:

110394763(TWSG1)

APLA:

101790638(TWSG1)

ACYG:

106034975(TWSG1)

CATA:

118256850(TWSG1)

AFUL:

116486402(TWSG1)

TGU:	100225938(TWSG1)

LSR:	110467836(TWSG1)

SCAN:

103826676(TWSG1)

PMOA:

120500844(TWSG1)

OTC:	121333245(TWSG1)

PRUF:

121359070(TWSG1)

GFR:	102032060(TWSG1)

FAB:	101811563(TWSG1)

OMA:	130249161(TWSG1)

PHI:	102106540(TWSG1)

PMAJ:

107200804(TWSG1)

CCAE:

111924973(TWSG1)

CCW:	104687281(TWSG1)

CBRC:

103612421(TWSG1)

ETL:	114056669(TWSG1)

ZAB:	102064066(TWSG1)

ACHL:

103800830(TWSG1)

SVG:	106850130(TWSG1)

MMEA:

130575185(TWSG1)

HRT:	120759193(TWSG1)

FPG:	101921226(TWSG1)

FCH:	102056014(TWSG1)

CLV:	102085660(TWSG1)

EGZ:	104132872(TWSG1)

NNI:	104017663(TWSG1)

PCRI:

104026083(TWSG1)

PLET:

104615620(TWSG1)

EHS:	104502529(TWSG1)

PCAO:

104053407(TWSG1)

ACUN:

113477129(TWSG1)

TALA:

104366206(TWSG1)

PADL:

103912286(TWSG1)

AFOR:

103902975(TWSG1)

ACHC:

115340194(TWSG1)

HLE:	104842480(TWSG1)

AGEN:

126051240

GCL:

127013177

CCRI:

104169474(TWSG1)

CSTI:

104553779(TWSG1)

CMAC:

104478615(TWSG1)

MUI:	104535189(TWSG1)

BREG:

104631435(TWSG1)

FGA:	104071580(TWSG1)

GSTE:

104252606(TWSG1)

LDI:	104348563(TWSG1)

MNB:	103779479(TWSG1)

OHA:	104326634(TWSG1)

NNT:	104400731(TWSG1)

SHAB:

115609311(TWSG1)

DPUB:

104308704(TWSG1)

PGUU:

104470742(TWSG1)

ACAR:

104519562(TWSG1)

CPEA:

104396956(TWSG1)

AVIT:

104281088(TWSG1)

CVF:	104290024(TWSG1)

RTD:	128904938(TWSG1)

CUCA:

104065502(TWSG1)

TEO:	104382536(TWSG1)

BRHI:

104496453(TWSG1)

AAM:	106484466(TWSG1)

AROW:

112972374(TWSG1)

NPD:	112954138(TWSG1)

TGT:	104565097(TWSG1)

DNE:	112979856(TWSG1)

SCAM:

104139115(TWSG1)

ASN:	102379599(TWSG1)

AMJ:	102564880(TWSG1)

CPOO:

109317384(TWSG1)

GGN:	109303245(TWSG1)

PSS:	102458434(TWSG1)

CMY:	102942527(TWSG1)

CCAY:

125632322(TWSG1)

DCC:	119852122(TWSG1)

CPIC:

101950443(TWSG1)

TST:	117873352(TWSG1)

CABI:

116822910(TWSG1)

MRV:	120397186(TWSG1)

ACS:	100564718(twsg1)

ASAO:

132775677(TWSG1)

PVT:	110088982(TWSG1)

SUND:

121932121(TWSG1)

PBI:	103054890(TWSG1)

PMUR:

107285982(TWSG1)

CTIG:

120306271(TWSG1)

TSR:	106548295(TWSG1)

PGUT:

117672648(TWSG1)

APRI:

131195175(TWSG1)

PTEX:

113435512(TWSG1)

NSS:	113414833(TWSG1)

VKO:	123021671(TWSG1)

PMUA:

114607255

PRAF:

128423874(TWSG1)

ZVI:	118092019(TWSG1)

HCG:	128322582(TWSG1)

GJA:	107106454(TWSG1)

STOW:

125439241(TWSG1)

EMC:	129333067(TWSG1) 129336163

XLA:	379560(twsg1.L) 399387(twsg1.S)

XTR:	448420(twsg1)

NPR:	108784579(TWSG1)

RTEM:

120940872(TWSG1)

BBUF:

121001737(TWSG1)

BGAR:

122938099(TWSG1)

MUO:	115476813(TWSG1)

GSH:	117353510(TWSG1)

DRE:	84037(twsg1a)

SRX:	107750930 107754584(twsg1)

SANH:

107687919 107690875

SGH:	107569636 107572616 107596295

CCAR:

109049291 109092459(twsg1)

CAUA:

113045283 113068742 113112583

CGIB:

127937853 127946006 127950390

PTET:

122330013(twsg1b) 122335656(twsg1a)

LROH:

127155498(twsg1b) 127181557(twsg1a)

OMC:	131525014(twsg1a) 131533355(twsg1b)

PPRM:

120461081(twsg1a) 120467836(twsg1b)

RKG:	130105603(twsg1a)

MAMB:

125251265(twsg1a) 125258395

CIDE:

127503335 127505592

MASI:

127431930 127434180 127440692 127442529

TROS:

130547142(twsg1b) 130555085(twsg1a)

TDW:	130413342(twsg1b) 130417183(twsg1a)

MANU:

129425537(twsg1b) 129443165(twsg1a)

IPU:	108271222(twsg1b) 108280863(twsg1a)

IFU:	128613728(twsg1b) 128624222(twsg1a)

PHYP:

113526381 113533166(twsg1)

SMEO:

124385318(twsg1b) 124402670(twsg1a)

TFD:	113644858 113645301(twsg1a)

TVC:	132845628 132846022(twsg1a)

AMEX:

103038715 103039237(twsg1)

CMAO:

118797323(twsg1a) 118821419

EEE:	113573124 113581942

CHAR:

105889420(twsg1a) 122132121

TRU:	101065019(twsg1)

TFS:	130538392(twsg1a)

TNG:	GSTEN00027677G001

LCO:	104933689(twsg1)

NCC:	104949675(twsg1)

TBEN:

117500247(twsg1a)

CGOB:

115023075(twsg1)

PGEO:

117462489(twsg1a)

GACU:

117540828(twsg1a)

EMAC:

134865509(twsg1a)

ELY:	117272027(twsg1a)

EFO:	125902025(twsg1a)

PLEP:

121951605(twsg1a)

SLUC:

116045845(twsg1a)

ECRA:

117954893(twsg1a)

ESP:	116698551(twsg1)

PFLV:

114565910(twsg1)

GAT:	120815665(twsg1a)

PPUG:

119209309(twsg1a)

AFB:	129089103(twsg1a)

CLUM:

117746002(twsg1a)

PSWI:

130197838(twsg1a)

MSAM:

119901818(twsg1a)

SCHU:

122887364(twsg1a)

CUD:	121520317(twsg1a)

ALAT:

119011851(twsg1a)

MZE:	101466460(twsg1)

ONL:	100698147(twsg1)

OAU:	116313428(twsg1a)

OLA:	101172607(twsg1)

OML:	112151905(twsg1a)

CSAI:

133451874(twsg1a)

XMA:	102225622(twsg1)

XCO:	114147103(twsg1)

XHE:	116722195(twsg1)

PRET:

103479729(twsg1)

PFOR:

103146322(twsg1)

PLAI:

106957671(twsg1)

PMEI:

106921611(twsg1)

GAF:	122840873(twsg1a)

PPRL:

129378038(twsg1a)

CVG:	107089431(twsg1)

CTUL:

119787204(twsg1a)

GMU:	124869270(twsg1a)

NFU:	107383543(twsg1)

KMR:	108232865(twsg1a)

ALIM:

106525789(twsg1)

NWH:	119414752(twsg1a)

AOCE:

111570828(twsg1)

MCEP:

125010308(twsg1a)

CSEM:

103396524(twsg1)

POV:	109642252(twsg1)

SSEN:

122780978(twsg1a)

HHIP:

117778871(twsg1a)

HSP:	118118434(twsg1a)

SMAU:

118311706(twsg1a)

LCF:	108884235(twsg1a)

SDU:	111231116(twsg1)

SLAL:

111658372(twsg1)

XGL:	120799472(twsg1a)

HCQ:	109529548(twsg1)

SSCV:

125985253

SBIA:

133511295(twsg1a)

PEE:	133411930(twsg1a)

PTAO:

133488720(twsg1a)

BPEC:

110174905(twsg1)

MALB:

109955294(twsg1)

BSPL:

114843892(twsg1a)

SJO:	128369065(twsg1a)

SASA:

100196167(tws1a) 106579643 106596679

STRU:

115150080 115157603 115170206 115195578

OTW:	112216473 112227786 112236168 112237438

OMY:	110489749 110509148 110530873 110535252

OGO:	123990280 124009950 124039151 124041043

ONE:	115120145 115130205

OKI:	109880790 109881556 109899326 109909797

OKE:	118371065 118372617 118378550 127910868

SALP:

111953189 111972778

SNH:	120027958 120050358

CCLU:

121532355 121534742 121549671 121570447 121580561

ELS:	105025315(twsg1) 105025733

SFM:	108930066(twsg1)

PKI:	111851396(twsg1)

AANG:

118226402 118233830

LOC:	102683664(twsg1)

PSPA:

121313530 121314471

ARUT:

117400732 117435693

PSEX:

120530349(twsg1a)

LCM:	102352072(TWSG1)

CMK:	103181048(twsg1a)

RTP:	109915229(twsg1a)

CPLA:

122548872(twsg1a)

HOC:	132815505(twsg1a)

LERI:

129696239(twsg1a)

PMRN:

116944172(TWSG1)

LRJ:	133350882(TWSG1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:	100303535(twsg1)

DME:	Dmel_CG11582(srw) Dmel_CG12410(cv) Dmel_CG1502(tsg)

DER:	6543829 6550966 6551174

DSE:	6610760 6612376 6620304

DSI:	Dsimw501_GD13268(Dsim_GD13268) Dsimw501_GD15950(Dsim_GD15950) Dsimw501_GD16744(Dsim_GD16744)

DYA:	Dyak_GE16419 Dyak_GE17577 Dyak_GE20626

DAN:	6502813 6504053 6504949

DSR:	110182017 110182573 110183593

DPO:	4812285 4814519 4814575

DPE:	113566314 6599788 6600790

DMN:	108151351 108152428 108164746

DWI:	6641203 6641357

DMO:	Dmoj_GI14766 Dmoj_GI16252 Dmoj_GI16812

DAZ:	108612519 108618328 108619179

DNV:	108655899 108657266 108658587

DHE:	111592353 111593437 111595269

DVI:	6624297 6631426 6633591

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119667844 119673036

MDE:	101890099 101890578 101892307

SCAC:

106084556 106084728 106095969

LCQ:	111681052 111683201 124420067

LSQ:	119601846 119605130 119611516

GFS:	119643056 119644801

ECOE:

129944874 129947172 129950768

CLON:

129606140 129614375 129614602

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

CQU:	CpipJ_CPIJ002575

CPII:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:	124404111 124412938

NPT:	124213333 124221175

NFB:	124175285 124184272

NLO:	107222317 107223247

NVG:	124296899 124307814

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:	109603756 109609323

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_214671

BANY:

MJU:

NIQ:

VCD:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105388788 105388896

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

MQU:

PHU:	Phum_PHUM538020

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_202071

DMK:

DPZ:

PVM:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

LOA:	LOAG_01687

TSP:

Tsp_04316

LGI:	LOTGIDRAFT_231460

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111134064 111137399

CANU:

128190095

OED:

125682968

MYI:	110444272 110448188

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106152967 106158029

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

Reference

PMID:11260715

Authors

Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS

Title

Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling.

Journal

Nature 410:475-8 (2001)
DOI:10.1038/35068572

Sequence

[hsa:57045]

Reference

PMID:15936330

Authors

Shimmi O, Ralston A, Blair SS, O'Connor MB

Title

The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing.

Journal

Dev Biol 282:70-83 (2005)
DOI:10.1016/j.ydbio.2005.02.029

Sequence

[dme:Dmel_CG12410]

Reference

PMID:7958834

Authors

Mason ED, Konrad KD, Webb CD, Marsh JL

Title

Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor.

Journal

Genes Dev 8:1489-501 (1994)
DOI:10.1101/gad.8.13.1489

Sequence

[dme:Dmel_CG1502]

LinkDB

DBGET integrated database retrieval system