KEGG ORTHOLOGY: K26128

ORTHOLOGY: K26128

Entry

K26128                      KO

Symbol

SHLD1

Name

shieldin complex subunit 1

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K26128  SHLD1; shieldin complex subunit 1
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    Other NHEJ factors
     K26128  SHLD1; shieldin complex subunit 1

Genes

HSA:	149840(SHLD1)

PTR:	458086(C20H20orf196)

PPS:	100992672(SHLD1)

GGO:	101144961(SHLD1)

PON:	100458276(C20H20orf196)

NLE:	100586738(SHLD1)

HMH:	116461102(SHLD1)

MCC:	718152(SHLD1)

MCF:	102117688(SHLD1)

MTHB:

126929130

MNI:	105481551(CUNH20orf196)

CSAB:

103246842(C2H20orf196)

CATY:

105582105

PANU:

103888093(SHLD1)

TGE:	112633794(SHLD1)

MLEU:

105530505

RRO:	104674572(SHLD1)

RBB:	108533267(CUNH20orf196)

TFN:	117068489(SHLD1)

PTEH:

111546464(SHLD1)

CANG:

105511012

CJC:	100387348(SHLD1)

SBQ:

101051834

CIMI:

108300984(SHLD1)

CSYR:

103266668(CUNH20orf196)

MMUR:

105865983(C18H20orf196)

LCAT:

123622140(SHLD1)

PCOQ:

105806171

MMU:	73747(Shld1)

MCAL:

110289572(Shld1)

MPAH:

110319394(C3H20orf196)

RNO:	681292(Shld1)

MCOC:

116090984(Shld1)

ANU:	117704559(Shld1)

CGE:	100773847(Shld1)

MAUA:

101831475(Shld1)

PROB:

127221404(Shld1)

PLEU:

114699532(Shld1)

MORG:

121460324(Shld1)

MFOT:

126496795

AAMP:

119815774(Shld1)

NGI:	103725550(CUNH20orf196)

HGL:

101717821

CPOC:

100733818(CUNH20orf196)

CCAN:

109688467

DORD:

105981447

DSP:	122120313(Shld1)

PLOP:

125353281(Shld1)

NCAR:

124978177

MMMA:

107139860(Shld1)

OCU:	100337713(SHLD1)

OPI:	101536358(SHLD1)

TUP:

102476165

GVR:

103590570

CFA:	100855997(SHLD1)

CLUD:

112673629(SHLD1)

VVP:	112930028(SHLD1)

VLG:	121478411(SHLD1)

NPO:	129521571(SHLD1)

AML:	109488321(SHLD1) 117800554

UAH:	113258359(SHLD1)

UAR:	123799605(SHLD1)

ELK:

111141698

LLV:

125108810

MPUF:

101673843

MNP:	132008174 132022675

MLK:	131808025(SHLD1)

NVS:	122916247(SHLD1)

ORO:

101374392

EJU:	114216365(SHLD1)

ZCA:	113937868(SHLD1)

MLX:	118011259(SHLD1)

NSU:	110579518(SHLD1)

LWW:	102735086(SHLD1)

FCA:	101081461(SHLD1)

PYU:	121012461(SHLD1)

PCOO:

112869285(SHLD1)

PBG:	122496546(SHLD1)

PVIV:

125161792(SHLD1)

LRUF:

124503313

PTG:

102967443

PPAD:

109274733(CUNH20orf196)

PUC:

125936796

AJU:	106980183(SHLD1)

HHV:	120226541(SHLD1)

BTA:	615129(SHLD1)

BOM:

102271125

BIU:	109568126(C13H20orf196)

BBUB:

102407807(SHLD1)

BBIS:

104986034

CHX:	102173580(C13H20orf196)

OAS:	101115387(SHLD1)

BTAX:

128058768(SHLD1)

ODA:	120868933(SHLD1)

CCAD:

122448229(SHLD1)

MBEZ:

129560042(SHLD1)

SSC:	100739819(C17H20orf196)

CFR:	102508208(SHLD1)

CBAI:

105083008

CDK:	105101377(SHLD1)

VPC:	102540400(SHLD1)

BACU:

103000973

BMUS:

118881684(SHLD1)

LVE:

103073367

OOR:	101289496(SHLD1)

DLE:	111165614(SHLD1)

PCAD:

102990245(SHLD1)

PSIU:

116740321(SHLD1)

NASI:

112412516(CUNH20orf196)

ECB:	100065580(C22H20orf196)

EPZ:

103563600

EAI:	106823194(SHLD1)

MYB:

102244543

MYD:

102772273

MMYO:

118663589(SHLD1)

MLF:	102420157(CUNH20orf196)

PKL:	118707887(SHLD1)

EFUS:

103285851(SHLD1)

MNA:

107536378

DRO:	112303791(CUNH20orf196)

SHON:

118990885(SHLD1)

AJM:

119051202

MMF:	118619004(SHLD1)

PPAM:

129070841(SHLD1)

HAI:	109383838(CUNH20orf196)

RFQ:	117016148(SHLD1)

PALE:

102888855(SHLD1)

RAY:

107519755

SARA:

101540042

SETR:

126017480(SHLD1)

LAV:	100660973(CUNH20orf196)

TMU:

101359830

ETF:	101660623(SHLD1)

DNM:	105745493(CUNH20orf196)

MDO:	100033294(C1H20orf196)

GAS:	123236894(SHLD1)

SHR:	100916342(SHLD1)

AFZ:

127548514

PCW:	110207725(CUNH20orf196)

PCOC:

116231196(SHLD1)

CJO:	107310944(SHLD1)

TPAI:

128075664(SHLD1)

LMUT:

125689852(SHLD1)

NMEL:

110395463(C3H20orf196)

APLA:

101795336(SHLD1)

CATA:

126913225(SHLD1)

TGU:	105759050(SHLD1)

PMOA:

120506939(SHLD1)

OTC:	121335820(SHLD1)

PRUF:

121358572(SHLD1)

GFR:

102039275

FAB:	101811320(C3H20orf196)

OMA:	130250881(SHLD1)

PHI:

102109840

PMAJ:

107201715(SHLD1)

CCAE:

111926553(C3H20orf196)

CCW:	104696622(SHLD1)

CBRC:

103625006(CUNH20orf196)

ETL:	114067258(SHLD1)

ZAB:	102072839(SHLD1)

ACHL:

103798994

SVG:

106863253

MMEA:

130584337(SHLD1)

HRT:	120750483(SHLD1)

FPG:

101911559

FCH:	102049530(SHLD1)

CLV:	110359685(CUNH20orf196)

PCRI:

PLET:

EHS:

PCAO:

ACUN:

113478872(SHLD1)

TALA:

122154776(SHLD1)

PADL:

103919570

AFOR:

103901669(CUNH20orf196)

ACHC:

115345168(SHLD1)

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

NNT:

SHAB:

115609938(SHLD1)

PGUU:

104468554

ACAR:

104521906(SHLD1)

BRHI:

104491556

AAM:

106499811

AROW:

112973172(SHLD1)

NPD:	112942918(SHLD1)

DNE:	112989365(SHLD1)

SCAM:

104151834

ASN:	102376158(SHLD1)

AMJ:	106737707(CUNH20orf196)

CPOO:

109319476(CUNH20orf196)

GGN:	109296471(CUNH20orf196)

PSS:	102452604(SHLD1)

CMY:	114021525(SHLD1)

CCAY:

125633361(SHLD1)

DCC:	119853227(SHLD1)

TST:	117874206(SHLD1)

CABI:

116824051(SHLD1)

MRV:	120400179(SHLD1)

ACS:	103279528(c1h20orf196)

ASAO:

132781711(SHLD1)

PVT:	110078951(CUNH20orf196)

PBI:	112540253(SHLD1)

CTIG:

120301801(SHLD1)

TSR:

106541125

PGUT:

117674344(SHLD1)

APRI:

131197216(SHLD1)

ZVI:	118082505(SHLD1)

HCG:	128340086(SHLD1)

EMC:	129333134(SHLD1)

XLA:

121394167

XTR:

105947450

NPR:	108795292(CUNH20orf196)

RTEM:

120938028

BBUF:

120998891

BGAR:

122934979

MUO:	115465659(SHLD1)

PSPA:

ARUT:

HOC:

LERI:

Reference

PMID:29656893

Authors

Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, Kremer M, Typas D, Lammers M, Mailand N, Nussenzweig A, Lukas J, Choudhary C

Title

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

Journal

Cell 173:972-988.e23 (2018)
DOI:10.1016/j.cell.2018.03.050

Sequence

[hsa:149840]

LinkDB

DBGET integrated database retrieval system