KEGG ORTHOLOGY: K26356

ORTHOLOGY: K26356

Entry

K26356                      KO

Symbol

LAT2, LAB

Name

linker for activation of T-cells family member 2

Pathway

map04650

Natural killer cell mediated cytotoxicity

Disease

H01439

Williams-Beuren syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K26356  LAT2, LAB; linker for activation of T-cells family member 2

Genes

HSA:	7462(LAT2)

PTR:	746841(LAT2)

PPS:	100971682(LAT2)

GGO:	101152656(LAT2)

PON:	100431505(LAT2)

NLE:	100587676(LAT2)

HMH:	116811601(LAT2)

MCC:	693676(LAT2)

MCF:	102117113(LAT2)

MTHB:

126950402

CSAB:

103246618(LAT2)

CATY:

105593344(LAT2)

PANU:

101015900(LAT2)

TGE:	112620056(LAT2)

RRO:	104681245(LAT2)

RBB:	108526527(LAT2)

TFN:	117072573(LAT2)

PTEH:

111547013(LAT2)

CANG:

105503696(LAT2)

CJC:	100397206(LAT2)

SBQ:	101028207(LAT2)

CIMI:

108307888(LAT2)

MMUR:

105858837(LAT2)

LCAT:

123632622(LAT2)

OGA:	100965414(LAT2)

MMU:	56743(Lat2)

MCAL:

110295145(Lat2)

MPAH:

110313140(Lat2)

RNO:	317676(Lat2)

MCOC:

116068509(Lat2)

ANU:	117697679(Lat2)

MUN:	110554209(Lat2)

CGE:	100771985(Lat2)

MAUA:

106021966(Lat2)

PROB:

127236900(Lat2)

PLEU:

114693647(Lat2)

MORG:

121446327(Lat2)

MFOT:

126516014

AAMP:

119825100(Lat2)

NGI:	103748491(Lat2)

HGL:	101725737(Lat2)

CPOC:

101789003(Lat2)

CCAN:

109687080(Lat2)

DORD:

105998498(Lat2)

DSP:	122114812(Lat2)

NCAR:

124970324

MMMA:

107146583(Lat2)

OPI:	105941926(LAT2)

TUP:	102495478(LAT2)

CFA:	102156541(LAT2)

CLUD:

112646134(LAT2)

VVP:	112935715(LAT2)

VLG:	121487904(LAT2)

NPO:	129519670(LAT2)

AML:	105238006(LAT2)

UMR:	103670232(LAT2)

UAH:	113267780(LAT2)

UAR:	123784730(LAT2)

ELK:

111145701

LLV:

125090914

MPUF:

101683503(LAT2)

MNP:	132026633(LAT2)

NVS:	122896188(LAT2)

ORO:	101374400(LAT2)

EJU:	114214430(LAT2)

ZCA:	113933201(LAT2)

MLX:	117999503(LAT2)

NSU:	110589875(LAT2)

LWW:	102735711(LAT2)

FCA:	101098351(LAT2)

PYU:	121017748(LAT2)

PCOO:

112859887(LAT2)

PBG:	122472034(LAT2)

PVIV:

125154108(LAT2)

LRUF:

124519119

PTG:	102966193(LAT2)

PPAD:

109250613(LAT2)

PUC:

125928175

AJU:

106977524

HHV:	120247357(LAT2)

BTA:	505016(LAT2)

BOM:	102265314(LAT2)

BBUB:

102390528(LAT2)

BBIS:

104998897(LAT2)

CHX:	102168964(LAT2)

OAS:	101114839(LAT2)

BTAX:

128043546(LAT2)

ODA:	120878256(LAT2)

CCAD:

122433163(LAT2)

MBEZ:

129545611(LAT2)

SSC:	100627864(LAT2)

CFR:	102515251(LAT2)

CBAI:

105082737(LAT2)

CDK:	105089682(LAT2)

VPC:	102543695(LAT2)

BACU:

103000397(LAT2)

BMUS:

118881366(LAT2)

LVE:	103075887(LAT2)

OOR:	101278886(LAT2)

DLE:	111182053(LAT2)

PCAD:

102980595(LAT2)

PSIU:

116739576(LAT2)

NASI:

112401130(LAT2)

ECB:	100062168(LAT2)

EPZ:	103541691(LAT2)

EAI:	106840989(LAT2)

MYB:	102247589(LAT2)

MYD:	102759053(LAT2)

MMYO:

118656736(LAT2)

MLF:	102423269(LAT2)

PKL:	118703567(LAT2)

EFUS:

103286260(LAT2)

MNA:	107526585(LAT2)

DRO:	112314763(LAT2)

SHON:

118992783(LAT2)

AJM:	119056338(LAT2)

PDIC:

114500451(LAT2)

PHAS:

123806496(LAT2)

MMF:	118642457(LAT2)

PPAM:

129083766(LAT2)

HAI:	109384969(LAT2)

RFQ:	117024427(LAT2)

PALE:

102889344(LAT2)

PGIG:

120591718(LAT2)

PVP:	105299671(LAT2)

RAY:	107502831(LAT2)

MJV:	108409126(LAT2)

TOD:	119242322(LAT2)

SARA:

101547551(LAT2)

LAV:	111752452(LAT2)

TMU:

111821328

DNM:	101433438(LAT2)

SHR:	105750556(LAT2)

AFZ:

127558704

PCW:	110221222(LAT2)

OAA:	103167804(LAT2)

GGA:	417489(LAT2)

PCOC:

116228192(LAT2)

MGP:	100551483(LAT2)

CJO:	107322489(LAT2)

TPAI:

128083364(LAT2)

LMUT:

125702854(LAT2)

NMEL:

110407883(LAT2)

APLA:

101790172(LAT2)

ACYG:

106041503(LAT2)

CATA:

118254160(LAT2)

TGU:	115497771(LAT2)

LSR:	110482067(LAT2)

SCAN:

103820054(LAT2)

PMOA:

120500642(LAT2)

OTC:	121333330(LAT2)

PRUF:

121351462(LAT2)

GFR:	102040860(LAT2)

FAB:	101809007(LAT2)

OMA:	130261022(LAT2)

PHI:	102114368(LAT2)

PMAJ:

107212854(LAT2)

CCAE:

111937663(LAT2)

CCW:	104691132(LAT2)

CBRC:

103621630(LAT2)

ETL:	114056686(LAT2)

ZAB:	102066158(LAT2)

ACHL:

103797781(LAT2)

SVG:	106860257(LAT2)

MMEA:

130579019(LAT2)

HRT:	120761397(LAT2)

FPG:	101912758(LAT2)

FCH:	102055718(LAT2)

CLV:	102090571(LAT2)

EGZ:	104131776(LAT2)

NNI:	104016160(LAT2)

EHS:	104511607(LAT2)

ACUN:

113487155(LAT2)

TALA:

116961772(LAT2)

PADL:

103912900

AFOR:

103896582(LAT2)

ACHC:

115347631(LAT2)

HLE:	104835491(LAT2)

AGEN:

126039220

GCL:

127024579

MUI:	104547750(LAT2)

GSTE:

104261313(LAT2)

MNB:	103778911(LAT2)

SHAB:

115601853(LAT2)

DPUB:

104300236(LAT2)

PGUU:

104470704(LAT2)

ACAR:

104529489(LAT2)

AVIT:

104279772(LAT2)

CVF:

104286569

RTD:	128913097(LAT2)

CUCA:

104060196

BRHI:

104493056(LAT2)

AROW:

112965033(LAT2)

NPD:	112956664(LAT2)

DNE:	112987370(LAT2)

ASN:	102372993(LAT2)

AMJ:	102558605(LAT2)

CPOO:

109317037(LAT2)

GGN:	109293470(LAT2)

PSS:	102444651(LAT2)

CMY:	114021773(LAT2)

CCAY:

125623792(LAT2)

DCC:	119844802(LAT2)

CPIC:

101939495(LAT2)

TST:	117867528(LAT2)

CABI:

116828604(LAT2)

MRV:	120387095(LAT2)

ASAO:

132763888

PVT:	110089232(LAT2)

SUND:

121916776

PBI:	103056041(LAT2)

TSR:

106544359

PGUT:

117667469(LAT2)

APRI:

131188786(LAT2)

VKO:

123023311

PMUA:

114585557(LAT2)

ZVI:	118096964(LAT2)

GJA:	107124739(LAT2)

EMC:	129345009(LAT2)

GSH:	117348747(LAT2)

DRE:	795391(si:dkey-183i3.6)

CCAR:

109108253

CGIB:

127986604(si:dkey-183i3.6)

PTET:

122326774(si:dkey-183i3.6)

LROH:

127152965(si:dkey-183i3.6)

OMC:	131529407(si:dkey-183i3.6)

PPRM:

120490105(si:dkey-183i3.6)

MAMB:

125253305(si:dkey-183i3.6)

CIDE:

127504137(si:dkey-183i3.6)

MASI:

127429394(si:dkey-183i3.6)

TROS:

130570558(si:dkey-183i3.6)

TDW:	130408010(si:dkey-183i3.6)

MANU:

129423536(si:dkey-183i3.6)

IPU:	108279234(si:dkey-183i3.6)

IFU:	128622463(si:dkey-183i3.6)

SMEO:

124397638(si:dkey-183i3.6)

TFD:	125139872(si:dkey-183i3.6)

AMEX:

103030058

CMAO:

118820408(si:dkey-183i3.6)

EEE:

113574969

TRU:

105417444

TFS:

130537020

TNG:	GSTEN00014632G001

NCC:

104965586

PGEO:

117458245

GACU:

117554583

EMAC:

134872459(si:dkey-183i3.6)

ELY:	117272424(si:dkey-183i3.6)

EFO:	125898893(si:dkey-183i3.6)

PLEP:

121952218(si:dkey-183i3.6)

GAT:

120821905

PPUG:

119215162(si:dkey-183i3.6)

AFB:	129113786(si:dkey-183i3.6)

CLUM:

117743248

PSWI:

130191982(si:dkey-183i3.6)

MSAM:

119895170(si:dkey-183i3.6)

SCHU:

122887945

CUD:	121518534(si:dkey-183i3.6)

ALAT:

119030898

PPRL:

129373372

CVG:

107098395

CTUL:

119774438(si:dkey-183i3.6)

KMR:	119617608(si:dkey-183i3.6)

AOCE:

111563007

MCEP:

125020753(si:dkey-183i3.6)

SSEN:

122780091(si:dkey-183i3.6)

HHIP:

117774829(si:dkey-183i3.6)

HSP:	118122308(si:dkey-183i3.6)

SMAU:

118300355(si:dkey-183i3.6)

LCF:	127143674(si:dkey-183i3.6)

XGL:	120802166(si:dkey-183i3.6)

SBIA:

133491821

PTAO:

133466782(si:dkey-183i3.6)

BSPL:

121202730(si:dkey-183i3.6)

SASA:

106567717

OTW:	112257971(si:dkey-183i3.6)

OMY:	110537601(si:dkey-183i3.6)

OGO:

ONE:

OKI:

OKE:

SALP:

SNH:

CCLU:

121573926(si:dkey-183i3.6)

ELS:

105023968

AANG:

118235622(si:dkey-183i3.6)

LOC:	107079930(lat2)

PSPA:

121308538(si:dkey-183i3.6)

ARUT:

117429098

PSEX:

120531316

LCM:	102352729(LAT2)

CMK:

RTP:

CPLA:

HOC:

LERI:

Reference

PMID:18645037

Authors

Whittaker GC, Burshtyn DN, Orr SJ, Quigley L, Hodge DL, Pascal V, Zhang W, McVicar DW

Title

Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.

Journal

Blood 112:2869-77 (2008)
DOI:10.1182/blood-2007-11-121590

Reference

PMID:12514734

Authors

Janssen E, Zhu M, Zhang W, Koonpaew S, Zhang W

Title

LAB: a new membrane-associated adaptor molecule in B cell activation.

Journal

Nat Immunol 4:117-23 (2003)
DOI:10.1038/ni882

Sequence

[hsa:7462]

LinkDB

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